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Micro-nano material for preventing and/or treating bone marrow suppression and application thereof

A myelosuppression and bone marrow technology, applied in the field of biomedicine, can solve the problems of easy to cause gastrointestinal reactions, can not be widely used, low absorption rate, etc. inhibiting effect

Inactive Publication Date: 2016-01-27
BEIJING FUNAKANG BIOTECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prevention and treatment of bone marrow hematopoietic suppression, although many Chinese and Western medicines have certain curative effects, their application is limited due to their low absorption rate in the human gastrointestinal tract and easy to cause gastrointestinal reactions; An effective treatment method is the use of hematopoietic growth factors (HGFs), but due to the high price and its own defects, it is not widely used at present

Method used

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  • Micro-nano material for preventing and/or treating bone marrow suppression and application thereof
  • Micro-nano material for preventing and/or treating bone marrow suppression and application thereof
  • Micro-nano material for preventing and/or treating bone marrow suppression and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1, the free radical scavenging effect of water-soluble gadolinium hydroxylated metal fullerene (GFNC) in vitro:

[0042] 1) Electron paramagnetic resonance (ESR) detection of free radical intensity experiment:

[0043] Using the method of ultraviolet induction to produce hydroxyl radicals, the control group is: 50 μL mass concentration of 37% hydrogen peroxide, 50 μL PBS buffer (pH=7.4) and trace (0.133mM) lutidine N-oxide (DMPO, free Radical capture agent) solution was mixed, irradiated with 280nm ultraviolet light for 8min, then the signal of hydroxyl radical could be generated; the experimental group was: 50 μL mass concentration of 37% hydrogen peroxide, 50 μL PBS buffer solution (pH=7.4) and trace ( 0.133mM) lutidine N-oxide (DMPO, free radical scavenger) solution mixed, immediately add 20μM water-soluble gadolinium hydroxylated metal fullerene aqueous solution 10μL, irradiate with 280nm ultraviolet light for 8min, detect the signal of free radical stre...

Embodiment 2

[0052] Example 2, the free radical scavenging effect of water-soluble hydroxylated hollow fullerene in vitro:

[0053] 1) Electron paramagnetic resonance (ESR) detection of free radical intensity experiment:

[0054] Using the method of ultraviolet induction to produce hydroxyl radicals, the control group is: 50 μL mass concentration of 37% hydrogen peroxide, 50 μL PBS buffer (pH=7.4) and trace (0.133mM) lutidine N-oxide (DMPO, free Radical capture agent) solution was mixed, irradiated with 280nm ultraviolet light for 8min, then the signal of hydroxyl radical could be generated; the experimental group was: 50 μL mass concentration of 37% hydrogen peroxide, 50 μL PBS buffer solution (pH=7.4) and trace ( 0.133mM) lutidine N-oxide (DMPO, free radical scavenger) solution mixed, immediately added 20μM water-soluble hydroxylated hollow fullerene aqueous solution 10μL, irradiated with 280nm ultraviolet light for 8min, and detected the signal intensity of free radicals .

[0055] Th...

Embodiment 3

[0063] Example 3. Myelosuppressive protection of water-soluble gadolinium hydroxylated metallofullerenes in vivo:

[0064] Animal model: 4-5 week old ICR mice were selected and randomly divided into 4 groups, 6 mice in each group, corresponding to blank control group, GFNC experimental group, cyclophosphamide (CTX) experimental group and CTX+GFNC experimental group respectively. Inoculate 10 on the right thigh of mice 6 A mouse hepatoma cell (H22 cell) was inoculated 5-7 days later, when the tumor diameter reached about 5 mm, the experiment was carried out.

[0065] Blank control group: the drugs injected in the experimental group were replaced by the same volume of normal saline, and the same volume of normal saline was injected intravenously and intraperitoneally.

[0066] GFNC experimental group: mice were injected with GFNC aqueous solution (1 mM) through the tail vein, and the drug dosage was 0.004 mmol GFNC / kg mouse body weight.

[0067] Cyclophosphamide (CTX) experiment...

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Abstract

The invention provides a novel application of a fullerene and / or metallic fullerene micro-nano material. The novel application is that of the fullerene and / or metallic fullerene micro-nano material in the preparation of drugs or drug carriers having at least one property as in 1) to 5): 1), preventing and / or treating bone marrow suppression; 2), clearing free radicals; 3), enriching bone marrow; 4), preventing and / or treating at least one of leukocyte decrease, platelet decrease, hemoglobin decrease and monocyte decrease caused by bone marrow suppression; 5), protecting bone marrow cells and / or hematopoietic cells. The fullerene and / or metallic fullerene micro-nano material is simple and quick to prepare, is good in biocompatibility and highly rich in bone marrow area, has certain residence time, can also be finally discharged out of the body by metabolism, has no evident cytotoxicity on bone marrow cells and normal cells and is safe and nontoxic. The fullerene and / or metallic fullerene micro-nano material has a promising application prospect as a protectant for bone marrow suppression caused by chemotherapy.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a micro-nano material for preventing and / or treating myelosuppression and its application, in particular to a new application of a fullerene and / or metal fullerene micro-nano material. Background technique [0002] In recent years, the incidence of malignant tumors has been increasing, seriously endangering people's health. Although a variety of cancer treatment methods have emerged in recent years, chemotherapy is still one of the commonly used clinical treatments for malignant tumors. As we all know, while most chemotherapy drugs kill cancer cells, they also damage the normal cells of the human body, which has relatively large side effects, especially for the killing effect on bone marrow cells, which may cause secondary damage to patients and even suffer from leukemia and other diseases. Seriously affect the quality of life of patients and its clinical application. At present, 60%-70...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61K47/04A61K47/02A61P39/06A61P7/00
Inventor 王春儒甄明明张莹
Owner BEIJING FUNAKANG BIOTECH CO LTD
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