Oxidized graphene-metallic fullerene compound, method for preparing same and application of oxidized graphene-metallic fullerene compound

A metallofullerene and composite technology, applied in the field of nanomaterials, can solve the problems of incomplete carbon cage structure, embedded metal leakage, etc., and achieve the effect of simple method, high relaxivity and good stability

Inactive Publication Date: 2016-02-03
INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the chemical modification on the surface of the metallofullerene carbon cage will cause the incomplete structure of the carbon cage, which will easily lead to the leakage of the embedded metal, resulting in toxicity and risks such as renal fibrosis.

Method used

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  • Oxidized graphene-metallic fullerene compound, method for preparing same and application of oxidized graphene-metallic fullerene compound
  • Oxidized graphene-metallic fullerene compound, method for preparing same and application of oxidized graphene-metallic fullerene compound
  • Oxidized graphene-metallic fullerene compound, method for preparing same and application of oxidized graphene-metallic fullerene compound

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 graphene oxide-metal fullerene compound

[0034] 1. Preparation of graphene oxide

[0035] According to Hummer's method: add graphite (0.25g) to concentrated sulfuric acid (11ml) at 0°C, and gradually add KMnO 4 (0.75g), control temperature is lower than 20 ℃, stir 4h, carry out low-temperature reaction; Be warming up to 35 ℃ afterwards, continue to stir 30 minutes, carry out medium-temperature reaction; Then add ultrapure water (12 milliliters) slowly, carry out high-temperature reaction, Keeping the solution temperature below 100°C, after stirring for 30 minutes, ultrapure water (30 mL) was added. Then, 30% hydrogen peroxide (2 ml) was added to remove unreacted KMnO 4 , the color of the solution turned bright yellow. The obtained product was washed with (150 ml 10 wt%) HCl and deionized water to remove metal ions and SO 4 2- .

[0036] Add the above-prepared product to ultrapure water, disperse by ultrasonic, ultrasonic for 100 mi...

Embodiment 2

[0046] The preparation of embodiment 2 graphene oxide-metal fullerene compound

[0047] 1. Preparation of graphene oxide

[0048] With embodiment 1.

[0049] 2. Preparation of graphene oxide-metal fullerene composites

[0050] Except that the metallofullerene was replaced by GdC60 in chlorobenzene solution (30 ml, 0.002 mg / mL), the rest of the steps were the same as in Example 1.

[0051] The obtained graphene oxide-metal fullerene composite has good water solubility and stability, good relaxivity, and good MRI enhancement effect.

Embodiment 3

[0052] The preparation of embodiment 3 graphene oxide-metal fullerene compound

[0053] 1. Preparation of graphene oxide

[0054] With embodiment 1.

[0055] 2. Preparation of graphene oxide-metal fullerene composites

[0056] The remaining steps were the same as in Example 1, except that the metallofullerene was replaced by a toluene solution of LaC82 (30 mL, 0.5 mg / mL).

[0057] The obtained graphene oxide-metal fullerene composite has good water solubility and stability, good relaxivity, and good MRI enhancement effect.

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Abstract

The invention provides an oxidized graphene-metallic fullerene compound. The oxidized graphene-metallic fullerene compound comprises oxidized graphene and metallic fullerene. The metallic fullerene is loaded to the surface of the oxidized graphene under pi-pi interaction. The invention further provides a method for preparing the oxidized graphene-metallic fullerene compound and application of the oxidized graphene-metallic fullerene compound as a magnetic resonance imaging contrast agent. The oxidized graphene-metallic fullerene compound, the method and the application have the advantages that the metallic fullerene is loaded on the surface of the oxidized graphene in a pi-pi interaction mode, the method is simple, complicated surface modification effects can be omitted, and the oxidized graphene-metallic fullerene compound is excellent in water solubility, stability, biocompatibility and relaxation property and is quite suitable to be used as the MRI (magnetic resonance imaging) contrast agent.

Description

technical field [0001] The invention relates to the field of nanomaterials, in particular to a graphene oxide-metal fullerene compound, its preparation method and its use as a magnetic resonance imaging contrast agent. Background technique [0002] Metallofullerene is a good magnetic resonance imaging contrast agent, which can only be applied after being modified and dissolved in water. For example, Chinese patent ZL03146028.3 discloses a metallofullerene hydrate, which can be used as a magnetic resonance imaging agent. Imaging contrast agent. However, the chemical modification on the surface of the metallofullerene carbon cage will cause the incomplete structure of the carbon cage, which will easily lead to the leakage of the embedded metal, resulting in toxicity and risks such as renal fibrosis. [0003] Graphene oxide has good water solubility, amphiphilicity, and large specific surface area. It can be used as a good drug carrier with low biological toxicity and good com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/08
Inventor 李娟崔荣丽孙宝云邢更妹
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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