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Applications of fullerene structure in preparation of drugs used for treating leukemia

A fullerene structure and fullerene technology, applied in the field of medicine, can solve problems such as applications affecting the quality of life of patients, damage to normal cells, secondary injury to patients, etc.

Inactive Publication Date: 2018-06-26
BEIJING FUNAKANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a variety of methods and drugs for the treatment of leukemia have emerged in recent years, such as the introduction of emerging targeted drugs and immunotherapy methods into China, they are still not widely used due to their mediocre effects, drug resistance, and high cost. Therefore, radiotherapy and chemotherapy are still commonly used in the clinical treatment of leukemia.
As we all know, while most radiotherapy and chemotherapy kill cancer cells, they also damage the normal cells of the human body, which has relatively large side effects, especially the killing effect on bone marrow cells may cause secondary damage to patients and even aggravate leukemia, which has a serious impact Quality of life of patients and its clinical application
However, bone marrow transplantation, which is recognized as a thorough cure for leukemia, first needs to wait for the bone marrow that matches the patient, and at the same time requires a large amount of funds to ensure that there is still a risk of recurrence after bone marrow transplantation. Many patients suffer from the pain and discomfort caused by transplantation. Fee reluctance to accept second transplant

Method used

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  • Applications of fullerene structure in preparation of drugs used for treating leukemia
  • Applications of fullerene structure in preparation of drugs used for treating leukemia
  • Applications of fullerene structure in preparation of drugs used for treating leukemia

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0054] The water-soluble hydroxylated gadolinium metallofullerene is prepared by the following preparation method:

[0055] 1) Add 300mg Gd@C 82 Put the solid powder into a 300ml single-necked bottle, add 20ml of 30% hydrogen peroxide aqueous solution and 10ml of 2M sodium hydroxide aqueous solution respectively, heat the oil bath to 70°C, and react for 6h;

[0056] 2) After the reaction, use a M.W.=3500 dialysis bag to remove small molecules, use a conductivity meter to monitor until the dialysis is completed, and the product obtained by ultrafiltration and centrifugation is water-soluble hydroxylated metal fullerene (Gd@C 82 ) m(OH) n , measured by DLS, its average particle size in aqueous solution is 140-150nm, and the particle size distribution is uniform.

preparation example 2

[0058] The water-soluble hydroxylated gadolinium metallofullerene is prepared by the following preparation method:

[0059] 1) Add 50mg Gd@C 82 Add the solid powder into a 100ml one-necked bottle, add 7ml of 30% hydrogen peroxide aqueous solution and 3ml of 2M sodium hydroxide aqueous solution respectively, heat the oil bath to 50°C, and react for 2h.

[0060] 2) After the reaction, use a M.W.=3500 dialysis bag to remove small molecules, use a conductivity meter to monitor until the dialysis is completed, and the product obtained by ultrafiltration and centrifugation is water-soluble hydroxylated metal fullerene (Gd@C 82 ) m (OH) n , measured by DLS, its average particle size in aqueous solution is 140-150nm, and the particle size distribution is uniform.

preparation example 3

[0062] The water-soluble hydroxylated hollow fullerene is prepared by the following preparation method:

[0063] 1) Add 200mg of C60 solid powder into a 200ml single-necked bottle, add 15ml of aqueous hydrogen peroxide solution with a volume fraction of 30% and 6ml of 2M aqueous sodium hydroxide solution, heat the oil bath to 70°C, and react for 5 hours;

[0064] 2) After the reaction, use a M.W.=3500 dialysis bag to remove small molecules, use a conductivity meter to monitor until the dialysis is completed, and the product obtained by ultrafiltration and centrifugation is water-soluble hydroxylated fullerene (C 60 ) m (OH) n , measured by DLS, its average particle size in aqueous solution is 150nm, and the particle size distribution is uniform.

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Abstract

The invention discloses applications of a fullerene structure in preparation of drugs used for treating leukemia. The fullerene structure is taken as an active ingredient, and comprises at least one ingredient selected from an oil soluble fullerene, an oil soluble metal embedded fullerene, a composition of the oil soluble fullerene and the oil soluble metal embedded fullerene, a water soluble fullerene, a water soluble metal embedded fullerene, a composition of the water soluble fullerene and the water soluble metal embedded fullerene, and a pharmaceutical ester or a pharmaceutical salt of theabove six ingredients. The active ingredient is capable of accumulating in bone marrow at a high efficiency; effects are achieved quickly; excellent biocompatibility is achieved; the fullerene structure can be used for preventing and treating leukemia before leukemia model maturation; after leukemia onset, the active ingredient possesses bone marrow part targeted enrichment characteristics, and can be used for rapid prevention, treatment, and repairing of bone marrow haematopoietic function damages by leukemia and other organic damages.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a fullerene structure in the preparation of medicines for treating leukemia. Background technique [0002] In recent years, with the change of the environment, the incidence of leukemia is getting higher and higher, seriously endangering people's health. Leukemia is a malignant clonal disease of hematopoietic stem cells. After suffering from leukemia, due to mechanisms such as uncontrolled proliferation of leukemia cells, impaired differentiation, and blocked apoptosis, a large number of proliferation and accumulation in hematopoietic tissues will infiltrate other non-hematopoietic tissues, which will inhibit normal hematopoietic function, and clinically, various degrees of anemia and hemorrhage will occur. , hepatosplenomegaly, bone pain and other symptoms. According to different standards, leukemia can have different classifications. According to the urgency of ons...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61P35/02
CPCA61K33/44A61P35/02
Inventor 王春儒张莹甄明明李慧白春礼
Owner BEIJING FUNAKANG BIOTECH CO LTD
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