47 results about "Medication hypertension" patented technology

Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

The invention discloses a preparation method for metoprolol salt, which includes the steps of utilizing p-(2-methoxyethyl) phenol and epoxy chloropropane as raw materials and water or ethanol as dissolvent, and obtaining 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane under the action of strong alkali; and utilizing water as dissolvent, carrying reaction between the 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane and isopropylamine so that metoprolol alkali is obtained, and then carrying out reaction between the metoprolol alkali and saturated monohydric alcohol liquor of organic acid or saturated monohydric alcohol liquor of hydrochloric acid, so that the metoprolol salt is obtained. Clinically, hydrochloride, succinate, fumarate or tartrate of the compound is utilized as common medicinefor treating hypertensive disease, coronary disease, congestive heart failure and arrhythmia. The raw materials of the preparation method are cheap and easy to obtain, the water and the ethanol are utilized as the dissolvent so as to hardly cause pollution, the method is convenient in operation, high in purity of the prepared metoprolol salt, high in yield, lower in cost and extremely suitable for mass production.

Disclosed herein is the treatment of vision loss in a mammal by transplanting an effective amount of hNT-Neuron cells. The treatment can be accomplished by injecting the cells into the retinal area of the eye. Additionally, the cells can be injected into the visual cortex of the brain. Conditions to be treated are vision loss due to optic nerve damage, including glaucoma, optic nerve sheath meningioma and glioma, Graves' ophthalmopathy, benign or malignant orbital tumors, metastatic lesions, tumors arising from the adjacent paranasal sinuses or middle cranial fossa, giant pituitary adenomas, brain tumors or abscesses, cerebral trauma or hemorrhage, meningitis, arachnoidal adhesions, pseudotumor cerebri, cavernous sinus thrombosis, dural sinus thrombosis, encephalitis, space-occupying brain lesions, severe hypertensive disease or pulmonary emphysema.

The present invention relates to a chewing gum comprising functional ingredients of mulberry leaves, which allows high absorption of the functional ingredients of mulberry leaves, and a method for the preparation of the chewing gum. This chewing gum containing functional ingredients of mulberry leaves includes: 15-30% (w / w) gum base, 60-80% (w / w) sugar alcohol, 0.1-0.5% (w / w) tenderizer, 0.1 -1.0% (w / w) humectant, 0.1-0.5% (w / w) emulsifier, 0.5-2.5% (w / w) flavoring agent, 0.01-10.0% (w / w) functional ingredients of mulberry leaves and 0.1-2.0% (w / w) fruit juice concentrate. This chewing gum containing functional ingredients of mulberry leaves can be practically applied to prescribed food and food replacement for patients suffering from constipation, diabetes and hypertension.

The invention discloses a flour compound suitable for hypertensive disease patients. The flour compound is made of semen Raphani, medlar, burdock roots, ginkgo leaves, radix puerariae, herba epimedii, chrysanthemum, rhynchophylla, eucommia, tabasheer, hawthorn, ginseng, mulberry leaves, Chinese yam, sweet potatoes, pea flour and whole wheat flour. The invention also discloses a preparation method of the flour compound. By eating the flour compound provided in the invention, blood pressure rise can be effectively controlled, and the adverse effects caused by drug therapy can be reduced.

The invention relates to a device for detecting blood pressure data. The device comprises a blood pressure measuring unit with an air pump, an inflatable cuff and a pressure sensor, wherein the pressure sensor is connected with a computer processing unit through an A / D conversion interface; the computer processing unit comprises a central processing unit CPU for operation, a memorizer, a communication interface and a human-computer interface; the computer processing unit is also connected with a pickup for acquiring voice of a user and a voice module for processing an audio frequency signal acquired by the pickup and converting the audio frequency signal into a digital signal; and the communication interface of the computer processing unit is connected with a data communication module for sending the blood pressure data and voice data to a network server. A doctor can make more accurate diagnosis according to a curve which is generated by the blood pressure data of multiple measurements and voice description of the user; and the device is expected to greatly improve the capabilities of diagnosing and controlling hypertensive disease.

The invention discloses a healthcare and nutrition ostrich egg liquid, which is mainly used for preventing and treating a hypertensive disease, and belongs to the fields of prevention and health protection of traditional Chinese medicines. The healthcare and nutrition ostrich egg liquid disclosed by the invention is prepared from the following components: ostrich eggs, semen coicis, mature vinegar, astragalus membranaceus, peach kernel, flowers carthami, angelica sinensis tail, ligusticum wallichii, radix paeoniae rubra, earthworm, hawthorn, rhizoma alismatis, polygonum multiflorum, radix rehmanniae recen, semen cassiae and liquorice. The healthcare and nutrition ostrich egg liquid has the efficacies of benefiting qi, nourishing blood, promoting blood circulation to remove blood stasis, relieving pain, nourishing the blood to expel wind, warming and activating meridians and reducing phlegm; the effective rate is 90%; the recovery rate is 80%; the average cure time needs three treatment courses (one month as one treatment course); the cure time for patients with serious conditions needs 0.5-1 year; and the healthcare and nutrition ostrich egg liquid can be scientifically taken according to the requirements, and has a relatively good market development prospect.

The present invention relates to a Chinese patent medicine for curing hypertensive disease, including the components of salvia miltiorrhiza, Herba Cephalanoploris, herba gynostemae, cassia seed, ginkgo biloba, common selfheal, hawkthorn, honey and dogbane leaf. Herba Cephalanoploris and hawkthorn are cleaned and decontaminated, then milled and filtered after dipping in water, and the drug liquid is for standby; danshen, herba gynostemae, ginkgo biloba, common selfheal, dogbane leaf and cassia seed are cleaned and decontaminated, decocted for twice and filter; the filtrate mixed with the drug liquid and added with honey is decompressed and condensed to 1 / 3 of the original volume; the drug liquid is placed until the temperature decreases to less than 40 DEG C and then added with ethanol for 24-hour settlement; the supernatant is filtered so as to recover ethanol. pH value is adjusted to 5.5 to 6.5 and water is added to 10,000ml. After shaking, standing, filtering, filling and sterilizing, the Chinese patent medicine is obtained. According to clinical observation, the present invention has the effect of reducing hypertension and hyperlipemia, softening blood vessels, and seeking both temporary and permanent solutions.

The invention discloses a traditional Chinese medicine composition capable of reducing the blood pressure and tonifying the kidney and a preparation method and application thereof. The traditional Chinese medicine composition is prepared with the following raw materials in parts by weight: 30-100 parts of sticktight, 10-30 parts of radix polygoni multiflori preparata and 3-15 parts of dogwood. In the preparation method, the traditional Chinese medicine ratio and formula of the traditional Chinese medicine composition provided by the invention are determined based on syndrome differentiation and treatment in accordance with the theory of traditional Chinese medicine, and the results of pharmacological experiments show that the traditional Chinese medicine composition provided by the invention has a good function of reducing the blood pressure with lasting stable effect and no recurrence, improving the biochemical indicators of the blood of patients with high blood pressure, basically preventing and treating hypertensive diseases, obviously preventing the hypertension-induced nephropathy and protecting the kidney. Moreover, the dosage of the traditional Chinese medicine composition provided by the invention is small, and no adverse reaction occurs in the experiment. Therefore, the traditional Chinese medicine composition can be used for treatment of hypertensive diseases and complications of hypertensive diseases and renal diseases.

The invention discloses a hear comforting and brain clearing traditional Chinese medicine composition. The purpose is to provide a Chinese medicine preparation which can improve the capacity of the cardiac muscles, has a cardiotonic effect, accelerate blood circulation, restrain thrombosis, regulate blood lipids, blood sugar and blood pressure, boost immunity, strengthen the spleen and nourish the stomach. The Chinese medicine preparation for treating the hypertensive disease comprises, by weight, the following raw materials: 6-10 pars of pseudo-ginseng, 15-30 parts of roots of red-rooted salvia, 10-15 parts of astragali radixes, 5-10 parts of gastrodia elata, 10-15 parts of chrysanthemum, 5-10 parts of ligusticum wallichii and 10-15 parts of seeds of wild jujubes.

The invention discloses a novel application of a traditional Chinese medicine extract product-Arctigenin in preparation of anti-arrhythmia medicines. A research found that the Arctigenin has bidirectional anti-arrhythmia effect and can adjust arrhythmia caused by aconitine and ouabain. Arctigenin has an effect for reducing ventricular muscle contraction force. A pharmacological effect of the Arctigenin is bidirectional adjusted cardiac muscle cell inner calcium current, the cardiac muscle cell inner potassium current is increased, and the sodium current is inhibited. The invention shows that the Arctigenin has anti-arrhythmia effect, and especially has bidirectional adjusting on arrhythmia, the side-effect is smaller, the Arctigenin has application prospect for treating toxic arrhythmia and ischemic-reperfusion arrhythmia in aconitine and ouabain; and the Arctigenin with myocardial contractility reduction effect can be taken as an auxiliary treatment measurement for hypertensive disease.

The invention discloses an orally-taken solid medicinal composition containing trandolapril and a preparation method thereof. The orally-taken solid medicinal composition comprises the following bulk drug components in percentage by weight: 0.1-0.9 percent of trandolapril, 15-65 percent of filling agent, 10-40 percent of bonding agent, 5-40 percent of disintegrating agent and 1-8 percent of glidant. The orally-taken solid medicinal composition containing the trandolapril, which is disclosed by the invention, is suitable for treating hypertensive diseases with various degrees and is formed by processing through a scientific and reasonable production process. The orally-taken solid medicinal composition has the advantages of definite functions, controllable quality and safety in taking. The orally-taken solid medicinal composition is simple in preparation method and can be prepared by conventional equipment.

The invention relates to an underwear fabric manufacturing process, which mainly comprises the steps of weaving and post-treatment and is innovatively characterized in that firstly gauze is woven; 23-30 parts of semen cassiae, 19-29 parts of raw sophora flower, 21-26 parts of kudzuvine root, 19-26 parts of tender uncaria, 23-29 parts of Scutellaria baicalensis, 28-36 parts of hawthorn, 29-34 parts of earthworm and 21-24 parts of fructus evodiae by weight are added into a pressure container, and temperature is increased to 60-78 DEG C and is kept constant for 120-140 minutes; and then post-treatment is conducted. Since semen cassiae, raw sophora flower, kudzuvine root, tender uncaria, Scutellaria baicalensis, hawthorn, earthworm, fructus evodiae and the like are added in the gauze, the medical efficacies can be slowly exerted when people wear the underwear for long time, the efficacies of the traditional Chinese medicine are respectively exerted, the effects of reducing blood pressure and reducing cholesterol are obtained, certain auxiliary curative effects of preventing and curing angiosclerosis and hypertensive diseases are obtained, the effect of reducing liver Yang exuberance syndrome hypertension is more remarkable, healthcare and treatment can be conducted during sleeping and the living needs of modern senile people are met.

Relating to the technical field of screening and application of aptamers, the invention provides an aptamer with xanthine oxidase inhibitory activity and application thereof. The DNA molecule of a nucleotide sequence of the aptamer is: TGCCTTACGTGGGCCTA TGCGTGCTACCGTGAAAG or a complementary sequence thereof, the aptamer with xanthine oxidase inhibitory activity is obtained through screening by combining magnetic bead-SELEX with capillary electrophoresis-SELEX technology, and can be applied to preparation of xanthine oxidase inhibitors or uric acid-lowering drugs. The invention overcomes the defects in the prior art, the aptamer has remarkable xanthine oxidase inhibition activity and uric acid reduction activity, can be used as a health care product and a drug lead compound for diseases like gout, hyperuricemia, coronary atherosclerotic heart disease, chronic heart failure, myocardial infarction, hypertensive disease, etc., and has good application prospects.

The invention discloses water-soluble yam residue diet fiber coffee milk, solving the problems that people who have three-high and constipation diseases are difficult to choose commercially available coffee milk. The water-soluble yam residue diet fiber coffee milk provided by the invention can alleviate constipation, keep the metabolic balance of human bodies, and prevent and treat the diseases such as diabetes, hypertensive disease, hyperlipidemia and high cholesterol, and is beneficial for human health.

The invention discloses a beer and sausage biscuit. The beer and sausage biscuit is processed by the following raw materials in part by weight: 50-60 parts of sticky rice, 45-50 parts of wheat flour, 35-45 parts of highland barley flour, 1-2 parts of cortex dictamni, 2-3 parts of cartialgenous, 1-2 parts of tuckahoe, 1-3 parts of obscured homalomena rhizome, 1-2 parts of borneol, 20-30 parts of potatoes, 14-18 parts of peas, 20-24 parts of bananas, 15-20 parts of sausage, 40-50 parts of beer, 6-10 parts of tea-seed oil, 1-2 parts of nutrition additives and a small amount of water. The main raw materials of the beer and sausage biscuit for increasing appetite are the sticky rice, the wheat flour and the highland barley flour; the beer and the sausage are particularly added in the biscuit, so that the taste of the biscuit is changed and is special; the beer can promote blood circulation, assists in digestion, has a diuretic function, increases the appetite, and has high auxiliary effects on a hypertensive disease, a heart disease, tuberculosis and the like; and the sausage has effects of appetizing, assisting in digestion and increasing the appetite. Moreover, the tea-seed oil which is added in the biscuit has effects of improving blood circulation, promoting digestion, strengthening internal secretion, strengthening bones, preventing radiation and resisting aging.

The invention relates to application of an SGLT2 inhibitor in combination with an ARB to preparation of a medicament for treating hypertensive disease and other diseases. Specifically, the SGLT2 inhibitor is selected from a compound (1) or a complex thereof or a medicinal salt thereof or a stereisomer thereof; the angiotensin II receptor antagonist (ARB) is selected from losartan, valsartan, irbesartan, candesartan, tasosartan, azilsartan, eprosartan, olmesartan or telmisartan. The general formula of the compound (1) is shown in the description.

The invention relates to a method for extracting medicine for treating human cardiovascular diseases from thalictrum robustum. The method comprises the following steps that thalictrum robustum is subjected to ultrasonic extraction and cation exchange resin desorption, wherein the solvent of the ultrasonic extraction is ethanol, the ultrasonic frequency is 25 to 35 kHz, the cation exchange resin desorption adopts sodium hydroxide water solution, and hydrochloric acid is adopted for desorption in desorption solution. According to the method, through ultrasonic extraction and cation exchange resin active ingredient adsorption, the finally obtained extracts can be used for effectively preventing and treating hypertensive diseases. The method has the advantages that the steps are simple, the influence on the activity of active ingredients is small, and the active ingredients of the extracts cannot be weakened, Compared with the existing extracting method, the method obtains the outstanding progress.

The invention discloses composition for treating hypertensive diseases and belongs to the field of Chinese pharmaceutical manufacturing. The composition is prepared from raw materials by weight as follows: 20-40 g of raw oyster, 10-18 g of radix scrophulariae, 12-17 g of white paeony roots, 14-18 parts of ramulus uncariae cum uncis, 8-12 g of radix achyranthis bidentatae and 2-6 g of radix glycyrrhizae. According to the scheme, the hypertensive diseases can be effectively treated, and pure traditional Chinese medicines are adopted for treatment, so that the composition has small side effects.

The invention provides a walnut oil-containing seal oil soft capsule mainly comprising the effective constituents: seal oil [containing EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), DPA (docosapentaenoic acid) and squalene], walnut oil and phosphatidylcholine. Main auxiliary materials comprise water, vitamin E, glycerinum and edible animal gelatin. By utilizing the walnut oil-containing seal oil soft capsule, cholesterol and fat in blood can be effectively reduced, blood viscosity can be effectively reduced, blood vessel can be effectively softened and expanded, diseases of artery blood vessel induration, thrombus, and the like can be effectively prevented, and the walnut oil-containing seal oil soft capsule has the effects of nourishing brain, improving memory and preventing hypertensive disease.

The invention relates to new technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs). The effect of the antihypertensive TCMs on improving microcirculation is evaluated through measurement of microvessel blood flow and the curative effects of the TCMs on treating hypertensive diseases and improving prognosis of the complications are further evaluated. The microvessel blood flow can be rapidly, intuitively and effectively measured by measuring the microvessel blood flow volume with a speckle full-frame real-time scanning imaging system in a non-contact and nondestructive manner and generating color images corresponding to measured areas in different perfusions. The new technology can be widely applicable to microcirculation of body surface parts of human bodies and common experimental animals and provides a more valuable basis for comprehensively evaluating the efficacy of the antihypertensive medicines.

The invention discloses a traditional Chinese medicine preparation for preventing and treating hypertensive diseases and a method for preparing the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises, by weight, 10-30 parts of astragalus, 5-15 parts of gastrodia elata, 5-15 parts of prepared pinellia tuber, 8-23 parts of poria cocos, 8-23 parts of rhizoma alismatis, 3-9 parts of pummelo peel and 5-15 parts of ligusticum wallichii. The traditional Chinese medicine preparation and the method have the advantages that effects of spleen invigorating, qi replenishing, dampness dispelling and phlegm dispersing can be realized by the traditional Chinese medicine preparation, and the traditional Chinese medicine preparation can be used for preventing and treating symptoms such as dizziness, headache, heavy sensation of the head, chest distress, excessive phlegm, fatigue and weakness, pale and fat tongue or white and slip tongues, slippery pulse or thin and weak pulse and the like due to hypertensive diseases; the traditional Chinese medicine preparation can be in an optional clinically suitable dosage form including a granule form, a mixture form, a capsule form, a pill form and a tablet form.

The invention belongs to the technological field of hypertensive diseases prevention and treatment, in particular to a medicine for preventing and treating various hypertensive diseases, in particular to the effective prevention and treatment of early hypertensive disease without any side effect. The invention is characterized in that the medicine consists of Chinese medicine earthworm, radix rauvolfiae verticillatae, aristolochia debilis, RhizomaChuanxiong and mint, and medical gel for external use and oral preparation are made.

The invention discloses a traditional Chinese medicine used for treating hypertensive diseases, and a preparation method thereof. The medicine is prepared from raw oyster, raw rehmannia root, lobed kudzuvine root, medicinal cyathula officinalis root, radix salviae miltiorrhizae, white peony root, Chinese wolfberry root-bark, and Szechwan lovage rhizome. During preparation, the raw oyster is decocted for 30min, and the rest medicine materials are soaked for 30min; the medicine materials are decocted on fire; after the medicine materials are boiling, the materials are decocted for half an hour; each preparation is decocted 2-3 times, and obtained medicine liquids are combined, such that a decoction of the medicine provided by the invention is obtained. If a patient suffers from severe dizziness and insomnia, common selfheal spike, tall gastrodia rhizome, raw dragon's bone, and tuckahoe can be added into the medicine. If arrhythmias and heart premature beat occurs, pilose asiabell root, creeping liriope, and tea root can be added into the medicine. If lumbar pain occurs, eucommia bark and Chinese taxillus herb can be added to the medicine. Other medicine materials such as Asiatic plantain herb, medlar, and motherwort can also provide an antihypertensive effect. The medicine provided by the invention has a comprehensive treatment effect.

The invention relates to polypeptide essence dietary nutrition powder and a preparation method thereof, which belongs to the technical field of functional food, uses isolated protein as the main ingredient, and adds corn oligopeptide, wheat oligopeptide, casein hydrolyzed peptide and fish collagen oligomerization Peptides, timely supplement of human peptides, and adding plantain seed coat powder, can effectively treat chronic bronchitis, acute and chronic bacillary dysentery, simple dyspepsia in children, hypertension, temporomandibular disturbance, etc.

The invention relates to a traditional prescription for treating the hypertensive disease. The traditional prescription is characterized by comprising 40 g of dry earthworms and 100 ml of white spirit in each dose. The manufacturing and taking method includes the steps that the dry earthworms are mashed to be put into the white spirit to be soaked for 72 hours; rocking is carried out two times each day; liquid is stored to be reserved after filtering and clarification are carried out; the liquid is taken with a small amount of warm boiled water three times each day after meals, and 10 ml of the liquid is taken each time; and if a person is bad in appetite, an appropriate amount of tincture of ginger can be added. The problems that when western medicines are taken by a patient for treating the hypertensive disease, the effect is not ideal, the hypertensive disease is prone to reoccurrence, resistance to the medicines is easily caused after long-time medicine taking, and side effects are caused are solved.

The invention relates to an internet of things with a lithium battery as power supply and for monitoring and treating hypertension and belongs to the technical field of applications of the internet of things. A first lithium battery is the power supply of an RFID (Radio Frequency Identification) reader-writer which respectively obtains hypertensive disease information in a first hypertensive patient electric tag, a second hypertensive patient electric tag and a third hypertensive patient electric tag through wireless communication. A second lithium battery is the power supply of a middleware; the hypertension information which is obtained through the RFID reader-writer is input into the middleware to perform screening and filtering of the data and then is input into a hypertension diagnosis computer which is operated by a doctor-in-charge to diagnose; the diagnosis result information is input into a hypertension dispensing computer through a data line to confirm dispensing information; and the dispensing information is input into a dispensing chamber through the data line. In the dispensing chamber, the best treating composition medicines for the hypertension are selected according to an automatic request of the dispensing information and the patient is informed to be identified and take the treating medicines in a medicine taking window.

The invention provides a heart-invigorating and meridian-warming pill, which relates to an orally taken Chinese patent drug pill for treating diseases such as palpitation, chest distress, flustering, head dizziness and the like caused by hypertensive disease. Developed for many years and verified through clinical practices, the heart-invigorating and meridian-warming pill is prepared from astragalus mongholicus, rhizoma nardostachyos, salvia miltiorrhiza, bezoar, liriope, schisandra chinensis, ginseng rootlet, trichosanthes kirilowii, fistular onion stalk, pinellia ternata, radix curcumae, corydalis tuber, cassia twig, honey-fried licorice root, scorpio and garter snake; the various raw materials are blended in a weight ratio; the mixture is crushed to fine powder (120 meshes); the fine powder is prepared into honeyed pills by a traditional Chinese medicine production method, and each pill is 9 g. The heart-invigorating and meridian-warming pill provided by the invention is clear in rules of treatment of the whole formula and rational in combination, and has the effects of warming heart yang, supplementing Qi and nourishing Yin and the like; the heart-invigorating and meridian-warming pill is good in curative effect and quick in taking effect for treating the diseases such as palpitation, chest distress, flustering, head dizziness and the like, and the effective rate is 100%; furthermore, the heart-invigorating and meridian-warming pill is capable of achieving the effect of treating both symptoms and root causes, and achieving the goal of not easy relapse after healing.