Novel application of Arctigenin in preparation of anti-arrhythmia medicine
A technology of arctigenin and arrhythmia, which is applied in the field of arctigenin anti-arrhythmia, a known Chinese medicine extract, and can solve problems affecting ion channels
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0041] The applicant found that arctigenin has the following effects in addition to the known effects in the patch clamp test of the action of arctigenin on the ion channel of rat cardiomyocytes:
[0042] (1) Reduce myocardial cell calcium current;
[0043] (2) Reduce the increase of calcium current in cardiomyocytes caused by aconitine, and resist the arrhythmia caused by aconitine;
[0044] (3) Antiarrhythmic effect caused by ouabain;
[0045] (4) Increase the transient outward potassium current of cardiomyocytes;
[0046] (5) Inhibit cardiomyocyte sodium current;
[0047] (6) Weaken the contractility of the heart and slow down the heart rate;
[0048] Therefore, arctigenin is a drug with clinical application value in the future.
[0049] 1. The effect of arctigenin on the contractility of rat cardiomyocytes induced by aconitine.
[0050]The preparation method of the isolated working heart refers to the reference document "Study on the Positive Inotropic Effects of Acon...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com