190 results about "Pharmaceutical manufacturing" patented technology

A system and method for using near-infrared or short-wave infrared (SWIR) light sources for identification of counterfeit drugs may perform spectroscopy using a super-continuum laser to provide detection in a non-contact and non-destructive manner at stand-off or remote distances with minimal sample preparation. Also, near-infrared or SWIR light may penetrate through plastic containers and packaging, permitting on-line inspection and rapid scanning. The near-infrared or SWIR spectroscopy may also be used to detect illicit drugs and their chemical composition. Moreover, the spectroscopic techniques may also be applied to quality assessment and control in pharmaceutical manufacturing, thus permitting the implementation of smart manufacturing with feedback control. Fiber super-continuum lasers may emit light in the near-infrared or SWIR between approximately 1.4-1.8 microns, 2-2.5 microns, 1.4-2.4 microns, 1-1.8 microns. In particular embodiments, the detection system may be a dispersive spectrometer, a Fourier transform infrared spectrometer, or a hyper-spectral imaging detector or camera.

Embodiments of the present invention are directed to a customizable bio-manufacturing system which includes a manufacturing space having a first air handling system for providing supply air and a second air handling system for handling exhaust air, the supply air system being optionally provided with at least one of filtration, heating, cooling and or humidity control and a plurality of portable modules provided within the manufacturing space. At least one module having an interior capable of being interconnected with another module interior and each module's interior includes one or more components to perform at least one specific task of a biological, chemical, and/or pharmaceutical manufacturing process. At least one module includes an on-board environmental control system for controlling an environment within the module and a connection means for interconnecting the module interior with another module interior. The system also includes a central controller operating to at least perform one or more of operation and information collection for the operation of at least one of the system and one or more modules.

Disclosed herein is a single use, controlled environment manufacturing module in the form of a sterile sealed bag formed of a substantially flexible material, such that the bag can be inflated and deflated for transport and/or disposal. The flexible bag has one or more access ports and connectors to accommodate a variety of biochemical or pharmaceutical manufacturing processes to be carried out within the flexible bag. The interiors of one or more disclosed modules can be connected, forming a module train.

A system and method for detecting, measuring, and analyzing for metallic impurities in pharmaceutical drugs and compounds utilizes an x-ray fluorescence system. The system and method may be co-located with a pharmaceutical manufacturing process for in-line continuous monitoring of metal impurities. The pharmaceutical products may be in a form selected from a powder, slurry, pill, tablet, and gel.

The invention provides a preparation method for a monoamine-grafted-and-modified crosslinked polyimide solvent-resistant nanofiltration membrane. The preparation method comprises the following steps: a, preparing a mixed solution from a solvent and a cosolvent according to a mass ratio of 1: 0.1-5; b, adding 15 to 28% of a polyimide solution into the mixed solution so as to prepare a membrane casting liquid; c, adding 2.5 to 20% of monoamine into the membrane casting liquid and carrying out mixing at 25 to 80 DEG C for 3 to 24 h under stirring so as to guarantee complete grafting; d, preparing a membrane by using a immersion-precipitation phases inversion process, washing the prepared membrane with deionized water a plurality of times and standing the washed membrane for subsequent usage; e, preparing an alcoholic solution of diamine with a concentration of 0.5 to 20%; f, putting the prepared membrane in the alcoholic solution of diamine prepared in the previous step for crosslinking modification for 0.25 to 48 h; and g, after completion of the reaction, soaking and cleaning the membrane in an alcohol solvent so as to obtain the polyamide nanofiltration membrane with excellent performance. The polyimide solvent-resistant nanofiltration membrane prepared in the invention has the advantages of simple preparation, adjustable hydrophilicity, outstanding solvent resistance, great permeation flux, a high retention rate, etc. and is applicable to separation of substances in all the organic solvents and to the fields of pharmaceutical manufacturing, biology, catalyst recovery, etc.

A web-based tool (as a server) for integrated pharmaceutical analysis and report generation service is provided in the present invention. The server can be used for numerical analysis and report generation for pharmaceutical manufacturing, research and development, and has advantages such as simple operation, complicated but fast calculation and professional report generation, and high accuracy. The server includes at least one pharmaceutical manufacturing and research and development numerical analysis system configured to perform different pharmaceutical manufacturing and research and development numerical analyses and generate different reports. Each of the at least one pharmaceutical manufacturing and research and development numerical analysis system includes an input module configured to receive, via a user interface, at least one of a template file and a backup file previously output by the server as at least one input file, wherein the at least one input file includes a plurality of data fields to provide corresponding data; at least one calculation module, each configured to execute a built-in pharmaceutical manufacturing and research and development numerical analysis calculation program, thereby automatically performing a pharmaceutical manufacturing and research and development numerical analysis calculation on at least one of the data of the at least one input file and on-line filled data; and an output module configured to generate at least one of a backup file and a report file as at least one output file based on the result of the pharmaceutical manufacturing and research and development numerical analysis calculation performed by the at least one calculation module and provide the at least one file via the user interface.

The invention belongs to the technical field of biological pharmaceutical manufacturing, and particularly relates to a transfer faction solution and a preparation method thereof. The preparation method comprises the following steps: mixing animal spleen and NaCl solution according to a weight ratio of 1:(1.3-1.4), performing repeated freeze-thaw, adjusting the pH value to 6.2-7.2, and filtering to obtain the transfer faction solution. By the adoption of the method provided by the invention, the content of effective components in the transfer faction solution can be increased advantageously, the product yield is improved, and the stability and the safety of a medicine are improved.

The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.

The invention provides an abiraterone derivative with an anti-cancer effect. The general structural formula of the abiraterone derivative is as shown in the description. The abiraterone derivative can ensure improvement of biophysics properties such as abiraterone solubility and bioavailability; the stability of the abiraterone derivative is maintained very well during pharmaceutical manufacturing and drug administration; and after drug administration, the abiraterone derivative can be degraded and release active compounds; and the abiraterone derivative has the characteristics of low toxicity and the like.

The invention relates to the technical field of Chinese pharmaceutical manufacturing, particularly to a method for extracting and further processing ainsliaea fragrans total flavonoid. With ainsliaea fragrans adopted as the raw medicinal material, the method comprises the following steps: firstly, smashing ainsliaea fragrans; carrying out ultrasonic immersion extraction on the smashed ainsliaea fragrans in ethanol water for a plurality of times; then, combining extracting solutions; decompressing and concentrating the extracting solutions; adding ethyl alcohol into the concentrated solution, and carrying out low-temperature standing for alcohol precipitation; filtering with a micropore filter membrane; decompressing and concentrating the filtrate; carrying out vacuum drying on the concentrated solution to obtain refined ainsliaea fragrans total flavonoid extract; finally, adding pharmaceutical excipients for further preparing the ainsliaea fragrans total flavonoid extract into various pharmaceutical preparations. According to the method, ultrasonic wave and continuous countercurrent extraction technologies are combined, so that the dissolution and spreading of the effective components are quickened, the extraction time is greatly shortened, the extraction efficiency is improved, the degradation of heat sensitive components is avoided, the energy consumption and production cost are further reduced, the extraction preparation technology is relatively simple and convenient, and the method is applicable to industrial large-scale production.

The invention relates to a peach seed-safflower Siwu granule containing medicinal materials like peach seed, safflower, Chinese angelica, common peony root, prepared rehmannia root and Ligusticum wallichii, and a preparation method thereof, belonging to the technical field of Chinese pharmaceutical manufacturing. The preparation method comprises the following steps: crushing peach seed, safflower, Chinese angelica, common peony root, prepared rehmannia root and Ligusticum wallichii, then adding water for decoction, combining two obtained decoctions, and then successively carrying out filtering, pressure-reduced concentration and spray drying so as to obtain dry powder; and then adding sugar and dextrin and then successively carrying out uniform mixing, granulation, drying and size finishing so as to obtain the peach seed-safflower Siwu granule. According to the invention, a spray drying manner is employed; product quality can be improved; quality indexes like the particle size distribution, moisture content, biological activity and dissolvability of drugs are controlled; and product purity and production efficiency are enhanced.

The invention relates to the field of pharmaceutical manufacturing equipment, in particular to a drying system. A cold and hot air alternative drying system comprises a drying cylinder and a heat pump connected with the drying cylinder; an air inlet pipeline is arranged between an air outlet of the heat pump and the drying cylinder; the cold and hot air alternative drying system further comprises a cold air blower; and an air outlet of the cold air blower is communicated with the drying cylinder through the air inlet pipeline. A photocatalyst device is arranged in the air inlet pipeline. Due to the adoption of the technical scheme, herbs are dehydrated at first, and then are dried through alternation of cold air and hot air to fully ensure the drying property of herbs; and the arrangement of the photocatalyst device solves the problem of sterilization of the cold air and hot air in the drying process.