Method for extracting and further processing ainsliaea fragrans total flavonoid

Abstract

The invention relates to the technical field of Chinese pharmaceutical manufacturing, particularly to a method for extracting and further processing ainsliaea fragrans total flavonoid. With ainsliaea fragrans adopted as the raw medicinal material, the method comprises the following steps: firstly, smashing ainsliaea fragrans; carrying out ultrasonic immersion extraction on the smashed ainsliaea fragrans in ethanol water for a plurality of times; then, combining extracting solutions; decompressing and concentrating the extracting solutions; adding ethyl alcohol into the concentrated solution, and carrying out low-temperature standing for alcohol precipitation; filtering with a micropore filter membrane; decompressing and concentrating the filtrate; carrying out vacuum drying on the concentrated solution to obtain refined ainsliaea fragrans total flavonoid extract; finally, adding pharmaceutical excipients for further preparing the ainsliaea fragrans total flavonoid extract into various pharmaceutical preparations. According to the method, ultrasonic wave and continuous countercurrent extraction technologies are combined, so that the dissolution and spreading of the effective components are quickened, the extraction time is greatly shortened, the extraction efficiency is improved, the degradation of heat sensitive components is avoided, the energy consumption and production cost are further reduced, the extraction preparation technology is relatively simple and convenient, and the method is applicable to industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of extraction and deep processing of traditional Chinese medicines, and in particular relates to a method for extracting and deep processing total flavonoids of apricot and rabbit rhizome. Background technique [0002] Apricot rabbit ear wind is the dry whole herb of Ainsliaea fragrans Champ (Ainsliaea fragrans Champ). Apricot Fragrant Rabbit Wind has the functions of clearing heat and detoxifying, dispelling stagnation, relieving cough, and stopping bleeding. It is often used for upper respiratory tract infection, lung abscess, tuberculosis hemoptysis, jaundice, infantile malnutrition, indigestion, mastitis, otitis media, acute and chronic Treatment of cervicitis and snake bites, etc. Xingxiang Tuerfeng is a commonly used folk medicine, but there are not many research reports in the literature at present. Its chemical components are mainly divided into flavonoids, terpenoids and phenolic acids, etc., all o...

AI Technical Summary

Problems solved by technology

[0003] In recent years, the patent applications or authorizations related to the extraction method of apricot rabbit ear wind mainly include: Chinese Patent Publication No.: CN101380347A discloses an invention patent named "Xingxiang rabbit ear wind total flavonoid extract and its extraction method and use", The traditional ethanol reflux extraction and macroporous adsorption resin separation technology are used to obtain the total flavonoids extract of apricot rabbit ear wind. This method is easy to destroy heat-sensitive components, and more organic solvents are used, which is prone to organic solvent residues and affects the quality of the drug. And the operation is comparatively loaded down with trivial details, and the production cost is higher; Chinese patent authorization announcement number: CN101293003B discloses the invention patent called " a kind of apricot-flavored rabbit wind effective part and its preparation method and application ", is firstly extracted by ethanol percolation, and then Petroleum ether and ethyl acetate were added successively for extraction, and finally the total phenolic acid components were obtained; Chinese patent authorization announcement number: CN101332216B discloses an invention patent named "Xingxiang rabbit wind total phenolic acid extract and its preparation method", which is also Through the traditional ethanol reflux extraction, and use hydrochloric acid to adjust the pH and separate the macroporous adsorption resin to obtain the total phenolic acid of apricot rabbit ear wind; Acid extract and its preparation and application" invention patent, which is also firstly extracted by traditional ethanol reflux, and the pH is adjusted with dilute hydrochloric acid, then adsorbed and eluted by macroporous resin HPD-826, the pH is adjusted again with hydrochloric acid, and then subjected to macroporous resin HPD-826 Porous resin HPD-826 is adsorbed, eluted, and finally dried to obtain the product; Chinese Patent Publication No.: CN103933094A discloses an invention patent named "A kind of Apricot Rabbit Wind Extract and Its Extraction Method and Application", which is firstly obtained by using ethyl acetate The ester is heated and extracted, concentrated and dried to obtain the ethyl acetate extract, and the dregs are extracted with methanol under reflux to obtain the methanol extract

[0004] These published documents and patents all extract the active ingredients of Xingxiang Tuerfeng through traditional extraction methods. These traditional extraction processes have common defects and deficiencies, including: the extraction process is relatively complicated, and heating is easy to cause heat The destruction of sensitive components, a large amount of organic reagents are used in the extraction, which may easily cause organic solvent residues in the extract, low extraction efficiency, high energy consumption and production costs, and low utilization of medicinal materials.

[0005] The present invention relates to a new method for extracting and further processing the total flavonoids of apricot and rabbit wind. From the documents and materials we have retrieved so far, there are no published documents and patents, and no related reports