The invention discloses a
tetrandrine lipid
nanoparticle ophthalmic preparation and a preparation method thereof, wherein the preparation method comprises the following steps of: adding
glycerol monooleate and
tetrandrine into absolute ethyl
alcohol, heating, carrying out ultrasonic dissolving and pressure-reducing rotary
evaporation, and removing all the ethyl
alcohol to obtain an
oil phase; (2)placing a slow-release material, a
penetration enhancer and a cationic material into
ultrapure water, stirring, heating and dissolving to obtain a water phase; (3) adding the water phase into the oilphase, shearing, dispersing and cooling to the
room temperature to obtain
colostrum; and carrying out
ultrasound to obtain the
tetrandrine lipid
nanoparticle ophthalmic preparation. The preparation has the advantages that the membrane superficial area is large, the
drug loading capacity is big; the resistance time of drugs in eyes is prolonged, the
bioavailability is improved, the
eye irritation and the
systemic toxicity caused by repeated administration and
high concentration of the drugs are avoided. The cationic material can be degraded
in vivo. The long-term stability of the preparation ishigh, the
solubility is improved and the
drug absorption is enhanced. The preparation has a
microstructure similar to a
biological membrane and is suitable as a carrier of a mucosal
drug delivery system.