The invention discloses an anticancer active molecular skeleton 1,4-
enyne compound, and a preparation method and application thereof. The preparation method comprises the following steps: an
allyl alcohol raw material, terminal
alkyne, tetrakis (
triphenylphosphine)
palladium,
calcium bis(
trifluoromethyl sulfonyl)
imide and an additive are added into a reaction
solvent in sequence; a catalytic reaction is carried out for 12-48 hours at an
argon atmosphere at a temperature of 100 DEG C and under a stirring state; a reaction
solvent in the reaction solution is removed; and purifying is carried outto obtain the anticancer active molecular skeleton 1,4-
enyne compound. The 1,4-
enyne compound can be used for medicines inhibiting human esophageal
carcinoma cells. The usage amount of a
palladium catalyst in the method is 1%, the usage amount of a
calcium catalyst is 5%, the usage amounts are extremely small, but an expected effect can be achieved. According to the method disclosed by the invention, the substrate application range is wide, and the
allyl alcohol can contain various substituted phenyls, heterocyclic rings and alkyls. The method disclosed by the invention is suitable for different types of
allyl alcohol, and the 1,4-enyne compound can be synthesized in a scale of 10 g. The 1,4-enyne compound disclosed by the invention has relatively good anti-
cancer activity.