The invention discloses a free radical cyclization reaction method based on 1,6-enynes and alcohol compounds, which belongs to the technical field of organic synthesis. The method comprises the following steps: using alcohol compounds as starting materials, Carry out cyclization reaction with 1,6-enyne compound, after the reaction is complete, post-treatment to obtain cyclization product 2-pyrrolidone compound. The method has cheap and easy-to-obtain raw materials, wide sources, stability and low toxicity, does not use any transition metal catalysts and ligands, and the reaction can be carried out in an air atmosphere with mild conditions, easy operation, no heavy metal residue in the product, and a wide range of reaction substrates. , Simple, efficient, economical and green, suitable for industrial production. At the same time, the present invention also provides an economical, practical and environmentally friendly new idea for the cyclization of alcohol radicals, expanding its application range.