63 results about "Corydalis edulis" patented technology

The invention provides Corydalis edulis extract, prepared by a method comprising the following steps: (1), after crushing a Corydalis edulis plant, and extracting with alkaline ethyl alcohol or methyl alcohol to obtain an extract; (2), subjecting the extract obtained in step (1) to normal pressure or vacuum concentration to obtain concrete, or spray drying to obtain powder; (3), adding an acid solution into the concrete or powder obtained in step (2), filtering to obtain an acid aqueous solution, adding an alkaline solution to the acid aqueous solution to obtain an alkali treated solution; (4), adding an organic solvent to the alkali treated solution obtained in step (3), vacuum recycling the organic solvent after extracting to obtain Corydalis edulis total alkaloids crude extract. The Corydalis edulis extract or a pharmaceutical composition containing the extract can be used to prepare pharmaceuticals for preventing and/or treating diseases caused by glucose and lipid metabolism disorder.

The invention relates to a corydalis ochotensis total alkaloid and a preparation method and a medicinal application thereof. The corydalis ochotensis total alkaloid is prepared by the following methods: grinding corydalis ochotensis into coarse powder; adding sulfuric acid solution with a concentration of 0.1-5% for soaking the coarse powder; then carrying out extraction by the sulfuric acid solution with a concentration of 0.1-5% by means of percolation; adjusting pH value of percolation liquid to 5-8 by NaOH solution; applying macroporous resin, eluting the percolation liquid by NaOH solution with a concentration of 1-10% until effluent liquid becomes almost colorless; washing the percolation liquid until the pH value of the percolation liquid ranges from 7 to 9; eluting the percolation liquid by ethanol with a concentration of 40% until the effluent liquid becomes colorless; eluting the percolation liquid by ethanol with a concentration of 80-95% until no alkaloid reactions occurs; and finally recovering ethanol by eluent and drying.The invention also relates to the application of the corydalis ochotensis total alkaloid in preparing medicine for improving memory function and treating senile dementia.Being a common medicinal material in Changbaishan Mount in China, the corydalis ochotensis is in existence in large quantities; therefore development of such a medicinal material is of positive significance.

The invention relates to the field of traditional Chinese medicines, particularly to traditional Chinese medicine composition for treating the cerebral thrombosis and a preparation method of the composition. The composition comprises components in parts by weight as follows: radix astragali, angelicae sinensis, white peony roots, fructus liquidambaris, cassia bark, centipedes, scorpions, safflower, pubescent angelica roots, ground beetles, roots of pseudo-ginseng, longan pulp, salvia miltiorrhiza, common selfheal fruit-spike, oriental waterplantain rhizome, gastrodia rhizome, ternate pinellia rhizome, dodder seeds, corydalis impatiens, emblic leafflower fruits, anomalous Artemisia, bear gall powder, bombyx batryticatus, Chinese clematis roots, suberect spatholobus stems, bile arisaema, licorice roots, lumbricus, chrysanthemums, peach kernels and fructus aurantii immaturus. The composition has functions of promoting blood circulation, removing blood stasis, resisting thrombus and freeing vessels and has the significant curative effect on the cerebral thrombosis.

The invention discloses a medicine composition for treating spleen and stomach damp-heat type peptic ulcer and a method for preparing the medicine composition. The medicine composition comprises diaphragma juglandis, Cipadessa cinerasce-ns (Pell.) Hand.-Mazz., radix glycyrrhizae, asian butteflybush roots and leaves, filipendula palmata, violet, codonopsis pilosula, smilax stans, hedyotis diffusa, herb of largeserrate molsa, fructus chaenomelis lagenariae, clerodenrum bungei steud, polygonum hydropiper, textile screw pine shoot, michelia alba, pararuellia delavayana, cirsium vlassovianum, camellia oil, biondia henryi, fructus psoraleae, cynanchum glaucescens, loofah juice, delavay falsepanax herb, blumea, caulis clematidis armandii, panax notoginseng, radix fici simplicissimae, corydalis gigantea Trautv. & C.A. Mey. and hypericum attenuatum. The medicine composition and the method have the advantages that effects of regulating spleens, harmonizing stomachs, clearing heat, removing dampness, promoting qi circulation and strengthening the spleens can be realized by the medicine composition, the medicine composition is mainly used for treating the spleen and stomach damp-heat type peptic ulcer, the stomach mucosae can be protected, the damp-heat constitution of patients further can be effectively improved, immune functions of the bodies of the patients can be integrally regulated, the medicine composition can become effective fast and is high in efficiency, short in treatment course, free of toxic and side effects and low in cost, definite curative effects can be realized, and the like.

The present invention provides a preparation method of tertiary amine alkali components in rhizoma corydalis. The preparation method of the provided components is as follows: berberine quaternary ammonium alkali in the rhizoma corydalis extract is reduced into protoberberine tertiary amine alkali, wherein two quaternary ammonium alkalis with highest content in the rhizoma corydalis, namely palmatine and dehydrocorydaline, are respectively reduced into tetrahydropalmatine and corydaline, pH of a reaction supernatant is adjusted to be neutral, dry-steaming is conducted, and drying is conducted after desalting to obtain the tertiary amine alkali components, wherein a total alkali content is 50% or more. The preparation method is simple in process, high in efficiency, high in recovery rate andlow in production cost, and provides a good technical scheme for developing safe, effective and controllable rhizoma corydalis alkali component preparations.

The invention discloses a production method of vinegar rhizoma corydalis decoction pieces, and belongs to the technical field of traditional Chinese medicine decoction pieces. The method includes thefollowing steps that rhizoma corydalis is cleaned, dewatered and dried; vinegar is added for covered moistening, and the rhizoma corydalis is steamed until the vinegar is completely absorbed; the finished product is dried and discharged after it is detected that the finished product is qualified. The method is easy to operate, reduces the waste of the vinegar, improves the utilization of the vinegar, can be used for evenly heating the rhizoma corydalis, and improves the quality and drug effect of the rhizoma corydalis.

The invention discloses a pharmaceutical composition for treating stomach cancer and a preparation method thereof. The pharmaceutical composition is prepared from crude drugs comprising mature seeds of entada phaseoloides, whole herb of corydalis hendersonii, whole herb of ajuga lupulina, sciadopitysin, taraxerol and inokosterone according to ratio, can be prepared into various dosage forms according to a conventional preparation process and has a remarkable curative effect for treating the stomach cancer.

The present invention discloses the new application of Corydalis CDL (CDL) in the field of analgesic drugs, and specifically discloses the application of CDL in the preparation of drugs for preventing or treating analgesic tolerance of opioid analgesic drugs. The corydalis dammine is used in combination with opioids, or used in compound preparations with opioids, which can enhance its analgesic effect and prevent or alleviate opioid tolerance in the course of chronic opioid treatment. This effect is achieved by inhibiting opioid-induced excessive activation of spinal cord microglial cells, and inhibiting opioid-induced excessive up-regulation of p-P38, p-ERK and p-JNK.

The invention discloses a preparation method of corydalis incisa amine. The preparation method comprises the following steps of: (1) taking hypecoum leptocarpum, crushing the hypecoum leptocarpum, adding ethanol for extraction, filtering and concentrating the hypecoum leptocarpum into thick paste with the relative density of 1.1-1.3; (2) taking the thick paste in the step (1), loading the thick paste on a macroporous resin column, sequentially eluting with water and ethanol, collecting an ethanol elution part, concentrating and drying to obtain a hypecoum leptocarpum refined extract; and (3) dissolving the hypecoum leptocarpum refined extract obtained in the step (2) in methanol, filtering, separating filtrate by using preparative high performance liquid chromatography, collecting a chromatographic peak fraction with the highest response value in a preparative chromatogram, concentrating and drying the fraction to obtain the corydalis incisa amine. The purity of the corydalis incisa amine prepared by the preparation method disclosed by the invention is greater than 98%.

The invention relates to a Tibetan medicine compound for treating calf diarrhea and a preparation method thereof, and relates to the technical field of medicines. The Tibetan medicine compound is prepared from the following raw materials in parts by weight: 1-3 parts of barberry root, 1-4 parts of hippophae rhamnoides, 5 parts of myrobalan, 2 parts of dracocephalum tanguticum and 2 parts of corydalis pygmaea. The Tibetan medicine compound disclosed by the invention has the effects of inhibiting bacteria, stopping diarrhea and easing pain, also has the effect of reducing intestinal advancement rate, inhibits intestinal epithelial cell shedding, reduces mucosal edema, reduces inflammatory cell infiltration, promotes rapid healing of diarrhea, does not easily generate bacterial drug resistance, and does not influence animal production performance.