Preparation method of corydalis incisa amine

A technology of cordydine and carved leaves, which is applied in the field of natural medicinal chemistry, and can solve problems such as unfavorable industrialization, pungent odor, and insufficient purity of cordydine

Pending Publication Date: 2021-09-10
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Zhang Ying et al., "Analysis of the Alkaloid Components of Corydalis" [J]. Journal of Plant Resources and Environment, 2008, 17(4): 67-69 provides a preparation method of Corydalis, but the method It is obtained by extracting and separating from Corydalis genus Papaveraceae, and the separation and purification reagents used in it, such as petroleum ether, chloroform, ammonia, etc., are po...

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  • Preparation method of corydalis incisa amine
  • Preparation method of corydalis incisa amine
  • Preparation method of corydalis incisa amine

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Embodiment 1

[0035] Embodiment 1, the preparation of Corydalis amine of the present invention

[0036] 1. Take 1 kg of dried fennel fennel, crush it, add 70% ethanol with 10 times its mass w / w, g / g, reflux extraction 3 times, each time for 2 hours, filter and combine the filtrates, i.e. filtrate A, The filtrate is concentrated under reduced pressure at a vacuum degree of 50-250mbar and a temperature of 40-60°C to a thick paste with a relative density of 1.1 to obtain a sample of the crude extract of fennel fennel;

[0037] 2. Take the ethanol crude extract sample of anise fennel described in step 1, which is adsorbed by a D101 type macroporous resin column with a column diameter ratio of 1 / 20-1 / 5, followed by 5 times column volume water, 5 times column volume Elute with 70% ethanol by volume, discard the water-washed part, collect the eluted part with 70% alcohol, concentrate and dry under reduced pressure at a vacuum degree of 50-250mbar and a temperature of 40-60°C to obtain a sample of ...

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Abstract

The invention discloses a preparation method of corydalis incisa amine. The preparation method comprises the following steps of: (1) taking hypecoum leptocarpum, crushing the hypecoum leptocarpum, adding ethanol for extraction, filtering and concentrating the hypecoum leptocarpum into thick paste with the relative density of 1.1-1.3; (2) taking the thick paste in the step (1), loading the thick paste on a macroporous resin column, sequentially eluting with water and ethanol, collecting an ethanol elution part, concentrating and drying to obtain a hypecoum leptocarpum refined extract; and (3) dissolving the hypecoum leptocarpum refined extract obtained in the step (2) in methanol, filtering, separating filtrate by using preparative high performance liquid chromatography, collecting a chromatographic peak fraction with the highest response value in a preparative chromatogram, concentrating and drying the fraction to obtain the corydalis incisa amine. The purity of the corydalis incisa amine prepared by the preparation method disclosed by the invention is greater than 98%.

Description

technical field [0001] The invention relates to the technical field of natural medicinal chemistry, in particular to a preparation method of corydone amine. Background technique [0002] Hypecoum leptocarpum Hook.f.et Thoms. is a plant of the genus Hypecoum leptocarpum Hook.f.et Thoms. It is one of the authentic varieties of traditional Tibetan medicine Hypecoum leptocarpum Hook.f.et Thoms. , Hepatitis, cholecystitis, joint pain, sore throat, red eyes, food poisoning and other effects. Due to the lack of chemical reference substances, the current Tibetan medicine standards promulgated by the Ministry of Health only have microscopic identification items for its quality control. [0003] According to the research on the chemical constituents of fennel, which can be consulted in the current literature, more than 20 alkaloid compounds have been reported, including hypecorine, hypecorinine, protopine, Coptis chinensis Coptisine, allocryptopine, corydam-ine, L-N-methyltetrahydro...

Claims

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Application Information

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IPC IPC(8): C07D491/056
CPCC07D491/056
Inventor 文怀秀苑祥陶燕铎邵贇梅丽娟
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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