Tibetan medicinal preparation for treating essential hypertension and preparation method thereof

A technology of essential hypertension and Tibetan medicine, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug delivery, etc., and can solve problems such as pressure rise, incomplete discharge, and pipeline blockage

Inactive Publication Date: 2015-01-14
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2) Caused by internal blood and thrombus caused by other diseases, blood metabolism and discharge are not thorough enough to form dirt inside the pipeline, which will block the pipeline to a certain extent and increase the pressure
[0016] At present, there is no report about the preparation of Tibetan medicine preparations containing the above components for the treatment of antihypertensive drugs

Method used

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  • Tibetan medicinal preparation for treating essential hypertension and preparation method thereof
  • Tibetan medicinal preparation for treating essential hypertension and preparation method thereof
  • Tibetan medicinal preparation for treating essential hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0091] [Experimental example 1] the influence of single administration of the medicine of the present invention on SHR tail artery blood pressure and heart rate

[0092] 1. Effect of single administration on SHR tail artery systolic blood pressure (SBP)

[0093] Model group systolic blood pressure is significantly higher than WKY group (P<0.01); Single gavage medicine of the present invention, medicine 1-12 group of the present invention all has the effect of obviously reducing tail artery systolic pressure in administration 3h, 6h, 12h, and Compared with the model group, there was a significant difference (P<0.05~0.01); the captopril group could significantly reduce the systolic pressure of the tail artery at 1h, 6h, and 12h after administration, and there was a significant difference compared with the model group (P<0.05~0.01). 0.01). The results are shown in Table 2.

[0094] Table 2 The influence of single administration of medicine of the present invention on SHR tail a...

experiment example 2

[0121] [Experimental Example 2] Effects of continuous administration of the medicine of the present invention for 4 weeks on SHR tail artery blood pressure and heart rate

[0122] 1. Effect of continuous administration for 4 weeks on SHR tail artery systolic blood pressure (SBP)

[0123] The systolic blood pressure of the model group was significantly higher than that of the WKY group (P<0.01); continuous administration of the medicine of the present invention, the medicine of the present invention 1-12 groups all had the effect of significantly reducing the systolic blood pressure of the tail artery in the first week of administration, compared with the model group There was a significant difference (P<0.05~0.01); the captopril group began to lower blood pressure at the first week of administration, and the antihypertensive effect continued until 4 weeks after administration, which was significantly different from the model group (P<0.01) . The results are shown in Table 6. ...

Embodiment 1

[0152] [Example 1] Preparation of Tibetan medicine slow-release preparation of the present invention

[0153] Caragana 100g, Pashaga 150g, Honglian 50g, Corydalis 150g, Songsheng et al. ointment 50g, Emlical seed 180g;

[0154] Remove impurities, wash and mix the medicinal materials such as Tibetan Caragana, Baxiaga, Honglian, Corydalis, Songsheng and other medicinal materials respectively, and reflux extraction with 65% ethanol 10 times the weight of the raw material medicine for 3 times, each time Extract for 2 hours, collect and combine the extracts, filter, concentrate the extracts into a concentrated solution with a relative density of 1.15; add conventional auxiliary materials, and make the slow-release preparation of Tibetan medicine of the present invention according to conventional processes.

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PUM

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Abstract

The invention relates to a Tibetan medicinal preparation for treating essential hypertension. The Tibetan medicinal preparation for treating the essential hypertension is prepared from the following raw medicinal materials in parts by weight: 100-200 parts of Tibetan caragana, 50-150 parts of Adhatoda Vasica Nees, 50-150 parts of Herba Lagotis, 50-150 parts of corydalis pygmaea, 50-150 parts of lignum rhamnellae ointment or 500-1500 parts of lignum rhamnellae and 80-180 parts of phyllanthus emblica. The Tibetan medicinal preparation for treating the essential hypertension has the effects of treating the essential hypertension and lowering blood pressure and can be used for preparing an antihypertensive drug.

Description

[0001] This application is a divisional application of Chinese patent application 201210290142.7 filed on August 15, 2012. technical field [0002] The invention relates to the field of traditional Chinese medicine, in particular to a Tibetan medicine preparation with antihypertensive effect and a preparation method thereof. Background technique [0003] Hypertension refers to an independent disease whose etiology is not yet clear and whose main clinical manifestation is systemic arterial blood pressure higher than the normal range. Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It has primary hypertension and secondary hypertension points. Essential hypertension, also known as hypertension, is an independent disease with elevated blood pressure as the main clinical manifestation and the etiology is not clear, accounting fo...

Claims

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Application Information

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IPC IPC(8): A61K36/80A61P9/12
CPCA61K36/48A61K9/0002A61K9/0053A61K9/0095A61K9/08A61K9/14A61K36/47A61K36/66A61K36/72A61K36/80A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 陈丽娟陈维武张国霞
Owner TIBET QIZHENG TIBETAN MEDICINE
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