The invention discloses an improved synthesis process for
lamotrigine. The process comprises the following steps: (1) synthesizing 2,3-dichlorobenzoyl
cyanide: adding 2,3-dichlorobenzoic acid and
thionyl chloride into a reactor, carrying out depressurized evaporating to remove
thionyl chloride after a reaction is completed, adding cuprous
cyanide into the reactor, and filtering out solids after a reaction is completed, so as to obtain a 2,3-dichlorobenzoyl
cyanide solution; (2) preparing a condensate: adding aminoguanidine
carbonate and an entrainer into a reactor, dropwise adding concentrated
sulfuric acid, distilling off the entrainer and water, carrying out suction
filtration, enabling solids to enter a reaction
bottle, carrying out depressurized pumping, then, adding the 2,3-dichlorobenzoyl cyanide solution obtained in the step (1) into the reaction
bottle, cooling the reaction
bottle to
room temperature after a reaction is completed, and carrying out suction
filtration, so as to obtain the condensate; and (3) preparing cyclics: adding liquid alkali into the condensate obtained in the step (2), and carrying out crystallizing, filtering, washing and baking after a reaction, thereby obtaining the
lamotrigine. According to the improved synthesis process for the
lamotrigine, the quality and yield of the product, i.e., the lamotrigine can be remarkably increased, and the yield reaches 90% or more.