The invention discloses a combined treatment method of N, N-dimethylformamide (DMF) wastewater, relates to the field of environment protection and water pollution treatment, and in particular relates to a combined treatment method for treating the N, N-DMF wastewater. The method specifically comprises the following steps: firstly decomposing the DMF wastewater into dimethylamine and formate under an alkali condition, then carrying out air stripping, introducing the dimethylamine waste gas generated in the air stripping into a bio-trickling tower for treatment, and directly carrying out biochemical treatment on the air-stripped wastewater. According to the combined treatment method disclosed by the invention, a physic-chemical method and a biological method are combined, a feasible process for treating the DMF wastewater is provided, the toxicity of the DMF wastewater is reduced by means of the physical-chemical method, the biodegradability of the DMF wastewater is improved, and the generated dimethylamine organic waste gas and wastewater are subjected to advanced treatment by means of the bio-chemical method. By adopting the combined treatment method disclosed by the invention, the effective and economical treatment of the DMF wastewater is achieved, and the problems of secondary pollution, difficult regeneration, low efficiency and the like easily caused by the existing treatment methods of adsorption, extraction, chemical oxidization and the like are solved.