The invention relates to a synergetic compound analgin injection and a preparation method thereof. The injection comprises the following components by weight in 100 milliliters: 10 to 30g of analgin, 2 to 4g of
antioxidant, 50 to 150mg of
dexamethasone sodium phosphate, 0.05g of EDTA (
ethylene diamine tetraacetic acid)-Na2, injection water filled until the amount reaches 100ml, and proper pH regulating agent, wherein the usage of the pH regulating agent is sufficient to regulate the pH value of the
system to be between 5.5 and 6.5. The preparation method comprises the following steps of adding the EDTA-Na2, the
antioxidant and the analgin into the injection water, stirring until the EDTA-Na2, the
antioxidant and the analgin are completely dissolved to prepare liquid A; dissolving the
dexamethasone sodium phosphate with trace injection water to prepare liquid B; adding the liquid B into the liquid A, uniformly stirring, continuously stirring for 20 minutes, regulating the pH value to be between 5.5 and 6.5, and fixing the volume to 100ml; filtering medicinal liquid, filling the filtrate into a
bottle with a filling and sealing
machine; and sterilizing for 30 minutes at a temperature of 115 DEG C and at a pressure of 0.2MPa, and cooling and outputting to obtain a finished product. The
dexamethasone sodium phosphate is added into the injection reasonably and compatibly, so that the
antipyretic effect is reinforced, and the function of anti-
inflammation and anti-
allergy are given at the same time. The synergetic compound analgin injection is wide in
drug effect and convenient to use.