Veterinary anti-inflammation traditional Chinese medicine composition as well as preparation method and application thereof
The technology of a composition and a traditional Chinese medicine is applied in the field of veterinary anti-inflammatory traditional Chinese medicine composition and its preparation field, which can solve the problems of growth and development impact of young animals, human health impact, gastrointestinal tract damage, etc., and achieves low cost, easy operation, and promotion of release effect
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Embodiment 1
[0021] Preparation of veterinary anti-inflammatory traditional Chinese medicine composition
[0022] (1) Take 20 parts of gypsum and decoct in water for 0.5h, then add 20 parts of Salvia miltiorrhiza, 20 parts of honeysuckle, 10 parts of Anemarrhena, 15 parts of raw land, 10 parts of buffalo horn and 5 parts of licorice, repeat the decoction three times, and combine the three decoctions , and then concentrated to a crude drug concentration of 1g / mL to obtain a concentrated solution;
[0023] (2) Add a gelatin solution with a mass fraction of 4% to the concentrated solution obtained in step (1) until no precipitation occurs after stirring, stop adding the gelatin solution, let stand at 4°C for 24 hours, and then filter to obtain filtrate I;
[0024] (3) Add absolute ethanol to the filtrate I obtained in step (2) according to the volume ratio of absolute ethanol to filtrate I 65:100, let stand at 4°C for 24 hours, centrifuge at a speed of 3000r / min for 10min, and filter to obtai...
Embodiment 2
[0027] Test the anti-inflammatory effect of the veterinary anti-inflammatory Chinese medicine composition of the present invention
[0028] Using dexamethasone as a positive control drug, observe that the veterinary anti-inflammatory Chinese medicine composition prepared in Example 1 causes swelling of mouse auricles caused by p-xylene, increased permeability of mouse capillaries caused by acetic acid, and small Mouse toe swelling, simultaneous determination of PGE2, MDA in the inflammatory exudate of mice caused by carrageenan, and NO, SOD in serum, to explore the anti-inflammatory effect of the veterinary anti-inflammatory Chinese medicine composition prepared in Example 1 part of the mechanism.
[0029] (1) Effects of Veterinary Anti-inflammatory Chinese Medicine Composition on Mouse Auricle Swelling in Example 1
[0030] Take 30 healthy Kunming mice of 18-22 g, half male and half male, and randomly divide them into 3 groups, 10 mice in each group, respectively dexamethaso...
Embodiment 3
[0059] Test the analgesic effect of the veterinary anti-inflammatory Chinese medicine composition of the present invention
[0060] Using dexamethasone as a positive control drug, observe the writhing response of the Chinese veterinary anti-inflammatory Chinese medicine composition prepared in Example 1 to the pain induced by acetic acid in mice, and study the analgesic effect of the Chinese veterinary anti-inflammatory Chinese medicine composition.
[0061] Take 30 healthy Kunming mice of 18-22 g, half male and half male, and randomly divide them into 3 groups, 10 mice in each group, respectively dexamethasone group, veterinary anti-inflammatory Chinese medicine composition group, and blank control group. The dexamethasone group and the veterinary anti-inflammatory Chinese medicine composition group were administered by intragastric administration of 0.1mL / 10g, and the blank control group was administered with the same volume of normal saline, wherein the drug concentration of...
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