212results about How to "Release completely" patented technology

The invention discloses a device for continuously producing exenatide microspheres and a method for controlling the release rate of microspheres. By adopting the device disclosed by the invention, a high pressure gas in a high pressure container is transferred to a squeezing device through a pipe, microspheres are squeezed, are solidified in a primary solidification device and then enter a soft microsphere collector, a hydraulic transfer valve is used to transfer the microspheres to a large-volume device, the microspheres are stirred and solidified, the microspheres are collected to perform freeze drying for standby. The method disclosed by the invention comprises the following steps: dissolving drug powder in a strongly polar solvent B1, then adding the solution in a weakly polar solvent B2 dissolved with a polymer according to a ratio, wherein the drug can not be dissolved in the solvent B2 and the solvent B1 and the solvent B2 are completely mutually soluble; adding a water-soluble substance C in the B1 / B2 mixed solvent, performing high-speed stirring to mix the solution evenly, then dispersing the prepared suspension in the aqueous phase, and volatilizing the organic solvent to obtain the controlled release microspheres encapsulating the drug. Compared with the prior art, the exenatide poly(lactic-co-glycolic acid) (PLGA) controlled release microspheres which has high encapsulation rate, no burst effect and can be released evenly and completely, are successfully prepared by the method disclosed by the invention.

An orally-applied ranolazine hydrochloride for treating cardiovascular disease is prepared from ranolazine hydrochloride, diluent, adhesive, disintegrant, antisticking agent and lubricant through adding wetting agent, preparing soft material, granulating and drying.

A rotary valve for metering the flow of particulate material from a supply source into the air stream of a pneumatic conveying system includes a central rotor manufactured through a precision casting process. The rotor is formed with a plurality of radially extending vanes terminating in tips that are flared circumferentially into the leading side of the vane to provide a flared vane tip that is preferably at least twice the thickness of the vane itself. The valve housing is formed with an elongated release port that has an overall length approximately equal to the length of the pockets formed between adjacent vanes to provide a more complete release of pressurized air from the pocket after the particulate material has been dropped into the pneumatic conveying system. The angled leading edge of the flared tips provides a less aggressive engagement with the particulate material to reduce damage thereto.