Cefuroxime axetil odor-masking pellet and preparation method

Abstract

The invention relates to a cefuroxime axetil odor-masking pellet and a preparation method thereof. The cefuroxime axetil odor-masking pellet consists of an uncoated pellet containing the cefuroxime axetil and an odor-masking layer coating outside the uncoated pellet. The cefuroxime axetil odor-masking pellet overcomes the defect of bitter taste of the prior cefuroxime axetil tablets, and provides a novel cefuroxime axetil preparation which masks bitter taste, releases medicament rapidly and has stable quality.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a taste-masked pellet of cefuroxime axetil and a preparation method thereof. Background technique [0002] The pellets prepared in the pharmaceutical industry are all between 500-1500um, and the pellets can be packed into capsules or compressed into tablets for use. Different prescriptions can be used to make the medicine into quick-release, slow-release or controlled-release pellets. Micropellet technology has developed rapidly since the advent of Spansolf in the 1950s. Micropill refers to a small spherical oral dosage form with a diameter of about 1mm, generally no more than 2.5mm. Since the micropill is a dose-dispersed preparation, a dose is composed of multiple units. Compared with a single-dose dosage form, it has the following advantages: (1 ) It can be coated with controlled-release pellets to make sustained-release preparations; (2) It ca...

AI Technical Summary

Problems solved by technology

However, the cefuroxime axetil raw material is unstable to humidity and heat, has poor water solubility, aggregates in water, and has a very bitter taste. Therefore, there is no cefuroxime axetil dosage form suitable for children on the market, which is unfavorable for children's administration.

[0004] The applicant's patent number is ZL200610095168.0, and the invention patent titled "Cefuroxime Axetil Taste-masked Pellets and Preparation Method", although there are "prepared Cefuroxime Axetil Taste-Masked Pellets with stable quality, rapid drug release, and masking However, due to the cavitating agent used in the taste-masking coating layer, the release of cefuroxime axetil preparations is incomplete and uneven, which affects the efficacy of cefuroxime axetil preparations.