The invention relates to improvement of a biological solidification and stabilization method of dredge bottom mud. The biological solidification and stabilization method is characterized by comprising the following steps: primarily dehydrating clay particles which have less possibility of being dehydrated, and mixing and stirring the dehydrated clay particles with dry soil to form mixed soil; and spraying a compound biological enzyme liquid at least consisting of reductase, amylase, cellulase, esterase, lipase, ligninase, prolease, urease, xylanase and a detergent surface active agent to be mixed with the mixed soil, then compacting and solidifying. The biological solidification and stabilization method has the advantages of short process flow and simplicity; by utilizing the method, the volume of the bottom mud to be solidified and stabilized is greatly reduced, the volume of the bottom mud to be solidified after classification and dehydration is 10%-15% of that of the bottom mud to be conventionally solidified, the processing flow is reduced compared with the existing biological enzyme solidification, the solidification cost is reduced, the solidification strength is high, the solidification filling shear strength can reach the Mpa grade, thus the method can be used for road construction, parking lots, slope solidification, reservoir surface solidification, refuse landfill bottom solidification and seepage prevention and public road building. By using the method, the outlet problem of the dredge bottom mud is effectively solved, and a novel decrement and solidification process for the bottom mud in the lakes is created.