44results about How to "No crystal" patented technology

This invention relates to preparation method of modified lignin poly carboxylic acid cement dispersant, belongs to concrete admixture. The process: whip amd heating-up lignin sulfonate to 50 to 80 deg, in turns add sodium dichromate 5 to 9 shares, polyvinyl alcohol 10 to 20 shares, acroleic acid 5 to 18 shares, initiator 0.1 to 3 shares, at temperature 80 to 100 deg, take reaction for 3 to 5 hours, gain modified lignin sulphonate water solution. The product brings the cement good consistency, not bleed air, without bleeding, good degree of fluidity and good flexibility.

The invention relates to a hyper-branched polycarboxylate high-efficiency water reducing agent and a preparation method thereof. The water reducing agent is prepared by polymerizing one of tert-butyl acrylate and methyl tert-butyl acrylate with sodium methyl-acryl sulfonate and allyl polyethenoxy ether to form a copolymer main chain, and then performing condensation polymerization on one of acrylic acid and methacrylic acid with ethylene diamine to form a hyper-branched polyamide structure which is grafted to two ends of the main chain. The preparation method comprises the following steps: (1)preparing the sodium methyl-acryl sulfonate into solution with DMF, and heating the solution in a nitrogen atmosphere; (2) dissolving the other two monomers and an initiating agent into the DMF to prepare mixed solution, and dripping the mixed solution into the step (1) to react for 1 to 20 hours; (3) adding a condensating agent CDI after the reaction and performing condensation reaction by usingN-methyl morpholine as an organic base, the ethylene diamine and the acrylic acid as the monomers and the DMF as a solvent; and (4) performing vacuum distillation to remove the residual monomers andthe solvent, and refluxing for 2 to 5 hours by using methylene chloride solution of trifluoroacetic acid to obtain the water reducing agent. The hyper-branched polycarboxylate water reducing agent hasthe advantages of low admixture, high water reducing rate, small slump loss, good compatibility with cement, no corrosivity to steel bars, strong frost resistance and the like.

The invention provides a heatproof lyoprotectant for a live vaccine against pseudorabies. The heatproof lyoprotectant comprises, by weight, 3 to 10 parts of gelatin, 1 to 5 parts of trehalose, 5 to 15 parts of sucrose, 0.1 to 2 parts bovine serum albumin, 1 to 8 parts of tryptone, 2 to 10 parts of enzyme-hydrolyzed casein, 1 to 5 parts of thiourea, 0.8 to 2 parts of L-monosodium glutamate, 0.1 to 3 parts of arginine, 0.5 to 5 parts of polyvinylpyrrolidone (PVP-K30) and 0.1 to 2 parts of mannitol. The invention also discloses a preparation method of the heatproof lyoprotectant and a lyophilized vaccine prepared from the heatproof lyoprotectant. When the heatproof lyoprotectant is used for protecting the vaccine and a specific lyophilization process is employed, lyophilization loss of viruses can be effectively reduced, the temperature tolerance of the viruses can be improved, and the vaccine can still maintain good physical properties and titer after long-term storage; i.e., the vaccine has stable characters and has the characteristics of heat resistance and long storage time.

The invention relates to a high-efficiency water reducing agent with good compatibility. A preparation method of the high-efficiency water reducing agent includes the steps: 1) in parts by weight, mixing 40-50 parts of sulfonation agents, 0-50 parts of liquid caustic soda and 150-180 parts of water to dissolve, then adding 50-60 parts of acetone, uniformly mixing the raw materials, and adding 15-150 parts of modifying agents to perform sulfonation reaction; 2) continuously dropping 135-165 parts of formaldehyde into an obtained solution system after sulfonation is finished, keeping the temperature of 95-98 DEG C after the formaldehyde is completely dropped to perform condensation reaction to obtain the high-efficiency water reducing agent with good compatibility. The high-efficiency water reducing agent with good compatibility has the advantages that the water reducing agent is low in mixing amount, high in water reducing rate and stable in product performance, and the high-efficiency water reducing agent can be compounded with traditional polycondensation-type high-efficiency water reducing agents such as naphthalene series and aliphatic series and high-performance water-reducing agents such as polycarboxylic acid.

The invention discloses a freezing-drying method for live vaccine. The freezing-drying method comprises the steps that the eutectic point range of a to-be-frozen and to-be-dried vaccine is tested, then, the live vaccine is placed in a vacuum freezing-drying machine pre-cooled to 0+ / -1 DEG C, when the temperature of a plate layer of the vacuum freezing-drying machine is reduced to be higher than the eutectic point of the live vaccine by 1-2 DEG C, the current state is kept for 1-2 h, and continuous cooling is conducted with the rate of 1 DEG C / h till all vaccine is frozen; and cooling is immediately conducted to the temperature needed for sublimation, and finally vacuum sublimation is conducted according to the normal procedure. The product obtained through the method is not provided with large ice crystals, sublimation is easy, and after freezing-drying, a good product physical behavior can be obtained, and the freezing-drying titer losses are minimal.