46results about How to "Accelerated sublimation" patented technology

An apparatus and method improves heating of a solid precursor inside a sublimation vessel. In one embodiment, inert, thermally conductive elements are interspersed among units of solid precursor. For example the thermally conductive elements can comprise a powder, beads, rods, fibers, etc. In one arrangement, microwave energy can directly heat the thermally conductive elements.

The invention provides a heatproof lyoprotectant for a live vaccine against pseudorabies. The heatproof lyoprotectant comprises, by weight, 3 to 10 parts of gelatin, 1 to 5 parts of trehalose, 5 to 15 parts of sucrose, 0.1 to 2 parts bovine serum albumin, 1 to 8 parts of tryptone, 2 to 10 parts of enzyme-hydrolyzed casein, 1 to 5 parts of thiourea, 0.8 to 2 parts of L-monosodium glutamate, 0.1 to 3 parts of arginine, 0.5 to 5 parts of polyvinylpyrrolidone (PVP-K30) and 0.1 to 2 parts of mannitol. The invention also discloses a preparation method of the heatproof lyoprotectant and a lyophilized vaccine prepared from the heatproof lyoprotectant. When the heatproof lyoprotectant is used for protecting the vaccine and a specific lyophilization process is employed, lyophilization loss of viruses can be effectively reduced, the temperature tolerance of the viruses can be improved, and the vaccine can still maintain good physical properties and titer after long-term storage; i.e., the vaccine has stable characters and has the characteristics of heat resistance and long storage time.

The invention discloses a preparation method for freeze-drying fruit and vegetable crisp slices. The preparation method comprises the following steps: blanching cleaned and split raw materials for enzyme deactivation, rapidly placing the raw materials after enzyme deactivation into a pre-cooling color-protecting liquid for cooling, pulping, homogenizing, paving material layers with thickness of 5-10mm in a metal material plate, inserting to an integrated metal grid mould, precooling at temperature of -30 DEG C, performing vacuum freeze drying according to the following process: when the temperature is lower than 10 DEG C, increasing temperature at the rate of 3-5 DEG C per hour, when the temperature reaches 10 DEG C, keeping the temperature for 1 hour, increasing temperature at the rate of 5-7 DEG C per hour, when the temperature reaches 40 DEG C, keeping for 2 hours, and then finishing the vacuum freeze drying. According to the invention, a proper amount of water is added into the raw materials for pulping and homogenizing, then curing is carried out, the integrated metal grid mould is used for accelerating the process that heat is conducted inside the material layers, the whole material plate is divided into a plurality of independent evaporation units, so that sublimation of water is greatly accelerated, obtained fruit and vegetable crisp slices are crisp and porous, good in reconstitution property, and the defect that the traditional freeze-drying fruit and vegetable crisp slices are poor in reconstitution property so as to stick teeth is overcome.

The invention provides roxatidine acetate hydrochloride used for injection and a preparation method thereof. The roxatidine acetate hydrochloride is prepared by taking the roxatidine acetate hydrochloride as a raw material; adding glycine or mannitol as an excipient; and freezing and drying after preparing the raw material and the excipient into a liquid medicament. The prepared roxatidine acetate hydrochloride used for the injection is used for upper gastrointestinal hemorrhage caused by gastric ulcer, stress ulcer and hemorrhagic gastritis and preanesthetic medication. The product obtained by the method has good quality, exact curative effect and stable quality.

The invention relates to a tetramethylpyrazine phosphate liposome drug and a preparation method; wherein, the drug is characterized in that: the effective efficacy components and weight accounts of the liposome drug are as following: a mixture 200 to330 with a weight ratio 4 to 1 of egg yolk lecithin and sheep cerebral lecithin, a mixture 170 to 280 with a weight ratio 3 to 1of stigmasterol and campestrol, reduction glutathione 2.5 to 10, tetramethylpyrazine phosphate 15 to 25, a mixture 720 to 1200 with a weight ratio 1 : 0.01 to 0.05 : 0.02 to 0.07 of tert-butyl alcohol, ethanol, acetone, a mixture 140 to 160 with a weight ratio 4:05 to 1 of polyethylene glycol-2000 and tween 801, and hydroxyl propyl methyl cellulose 100 to 120. The invention also provides the preparation method for the liposome drugs. The invention has the advantages of adopting the provided drugs, enabling to decrease the drug dosage by two third and once a day, and improving the efficacy above fifteen percent.

The invention discloses a drying method for lentinus edodes. The drying method comprises the steps of material selection and classification, cleaning for removing impurities and drying treatment for lentinus edodes. According to the drying method, the steps are reasonably matched, and the prepared lentinus edodes is pure in color, strong in flavor and good in appearance and quality. Compared with the existing drying technology, the formaldehyde content of the dried lentinus edodes can be reduced by about 40%, and the reconstitution properties are good, the time for soaking with cold water is only 8-12 minutes, and the mouthfeel is good.

In a process for coating a substrate, the substrate is arranged opposite a removal surface of a target and the coating material is atomized by sputtering under an inert or reactive-gas-containing process gas and deposited on the substrate. The coating takes place from a mixed target with at least one target component A and a target component B. At the beginning of the sputtering process, the distribution of the target components A and B in a superficial target layer of the removal surface is modified by high-power impulse magnetron sputtering.

The invention discloses a raw material sintering process of silicon carbide crystals grown by a PVT (physical vapor deposition) method. The silicon carbide raw material is led to the sintering processwith the PVT method, a sintering fixture is designed, the silicon carbide is sintered through the previously designed sintering fixture, and the silicon carbide crystals are grown by the PVT method.The raw material sintering process has the advantages that the silicon carbide raw material forms a certain structure through sintering of the silicon carbide raw material, crystallization of the silicon carbide raw material is weakened, densification degree of the silicon carbide raw material is lowered, impurities carried in the silicon carbide raw material can be removed during sintering, fullsublimation and stable growth speed of the silicon carbide crystals by the PVT method can be effectively controlled and maintained, and the yield of the utilization of the silicon carbide raw materialand the silicon carbide crystals is increased.

The invention relates to a novel preparation process for a thermal barrier coating. The novel preparation process comprises the following steps: generating a metal bonding bottom layer on the surfaceof a matrix; generating an in-situ thermal growth oxide layer (TGO); and generating a ceramic heat-insulating surface layer, wherein the TGO layer is pre-grown before the matrix serves. The TGO layercomprises alpha-aluminum oxide. A compact and continuous TGO layer which takes alpha-aluminum oxide as the principal component is preset through large-particle dry ice jetting and purifying rougheningtreatment and pre-vacuum argon gas oxidizing treatment. An oxide film has very good high-temperature oxidization resistance, prevents quick oxidization, reduces a layer thickness increase rate of theTGO layer, and achieves the purpose of reducing thermal barrier coating peel-off probability.

Organic luminescent materials containing cycloalkyl ancillary ligands is disclosed, which can be used as emitters in the emissive layer of an organic electroluminescent device. The organic luminescent materials is metal complexes which comprise a new series of cycloalkyl containing acetylacetone type ancillary ligands. These novel ligands can effectively improve the lifetime of the device, change the sublimation characteristics and improve device performance. Also disclosed are an electroluminescent device and a formulation.

The invention discloses a method for improving pore-forming efficiency of a metal sublimation pore-forming method based on an element reaction / diffusion principle. The method comprises the following steps of a, adding one or more metal pore-forming elements easy to sublimate in a certain proportion into a sample to be pore-formed in a preparation process, and putting the sample into a hearth of ahigh vacuum furnace after preparation; b, installing a vapor absorption objective table in a sintering chamber, and adding a pressed reactant capable of reacting with the sublimating metal elements onthe vapor absorption objective table; and c, sintering the sample in the sintering furnace with high vacuum degree to form holes inside and on the surface of the sample. The sublimated metal vapor reacts with the reactant on the vapor absorption objective table, so that the reaction process is accelerated, the pore formation efficiency is improved, and a porous material with high porosity is obtained. The method has the characteristics of simple process, low cost, high universality and the like, and can be widely applied to the field of preparing porous materials by using the metal pore-forming elements easy to sublimate.

The invention discloses somatostatin powder injection composition and a preparation process thereof. The somatostatin powder injection composition is prepared from somatostatin, a freeze-dried carrieror an excipient and a local laminating brominated butyl rubber plug for freeze-drying injection. Somatostatin and the freeze-dried carrier or the excipient are mixed, and a proper amount of water forinjection is added for dissolution; activated carbon is added for filtration, an acid or alkaline regulator is added to regulate the pH value, the water for injection is added to the prescribed volume, and subpackaging is performed; sub-packaged products are half tamponed and put in a freeze-drying machine to be freeze-dried; nitrogen charging, tamponing and discharging are performed. The pH change of somatostatin in preparation of freeze-dried powder injection and long-time storage of a finished product is remarkably inhibited, the stability of the freeze-dried powder injection is effectively improved, long-time storage at the normal temperature of 25 DEG C is realized, the freeze-drying time is shortened, a large amount of energy consumption is saved, the production cost is substantially reduced, the formability of the finished product is good, and the composition has no withering property and is tidy and attractive in appearance.

The invention provides a special filter for bee milk freeze-dried powder and a using method of the filter, and relates to the technical field of filtering. The filter comprises a machine shell, a beemilk inlet is formed in the upper end of the machine shell, a temperature sensor is arranged on the surface of the machine shell, an infrared ray measuring gauge is arranged on one side of the temperature senor, a water inject port is formed in one side of a stirring chamber, adsorption cavities are formed in the two ends of the inner wall of the stirring chamber correspondingly, a telescopic joint is arranged on the surface of a stirring rod, rotating blades are arranged at the lower end of the stirring rod, a filtering device is arranged at the lower end of the stirring chamber, a drawing and pulling plate is arranged on one side of the filtering device, a guiding hopper is arranged at the lower end of the filtering device, a discharging port is formed in the lower end of the guiding hopper, supporting columns are arranged on the two sides of the machine shell correspondingly, and an adjusting plate is arranged at the lower end of a second pressing plate. The special filter solves the problem that bee milk is prone to running off when an existing filter in the market filters the bee milk, residues on the surface of a filter screen is not easy to remove if the filter is used for along time, the temperature cannot be adjusted and decreased by self adapting the temperature, and accordingly the processing efficiency of the device is lowered.

The invention discloses a modified polyethylene terephthalate (PET) film for a lithium battery flexible packaging film. The modified PET film consists of the following components in parts by weight: 70-80 parts of terephthalic acid, 120-150 parts of ethylene glycol, 10.5-32.4 parts of nano montmorillonite, 0.5-10 parts of a dispersant and 0.1-20 parts of a coupling agent. According to a preparation method of the modified PET film, terephthalic acid and ethylene glycol is subjected to an esterification reaction first to generate polyethylene terephthalate with a low polymerization degree, and then the polyethylene terephthalate with a low polymerization degree is subjected to a polycondensation reaction. In a process of the polycondensation reaction, the nano-montmorillonite is distributedin PET in a lamellar shape under action of the dispersant and the coupling agent to obtain modified PET, and the problem of poor barrier property of a conventional PET film is solved.

The invention discloses waterless reverse micelles nanoparticles of a water-soluble drug, and a preparation method of a suspension aerosol thereof. The preparation method comprises the following steps: dissolving the water-soluble drug and a freeze-drying protectant into water as an aqueous phase; dissolving amphiphilic substances into tert-butyl alcohol as an oil phase, stirring uniformly in a water bath at a constant temperature, adding dropwise the oil phase into the aqueous, getting a nano suspension with a bilayer vesicles structure; freezing the nano suspension rapidly and solidifying, getting a freeze-drying product; adding an organic phase into the freeze-drying product, and getting the waterless reverse micelles nanoparticles; filling a spray bottle with the nanoparticles and nitrogen, sealing, pressing a propellent into the spray bottle, and getting the suspension aerosol. The preparation method of the invention helps to prepared the nanoparticles with a lipid vesicle structure in uniform particle size by one step, and the drug molecules are not easy to damage; and by taking tert-butyl alcohol / water as a solvent, energy consumption in the freeze-drying process is reduced, solvent sublimation is accelerated, and freeze-drying time is shortened. The nanoparticle suspension aerosol is high in sedimentation rate in vitro of pulmonary delivery, and helps to improve drug absorption.

The invention discloses a proteinase K freeze drying technology which comprises the following steps: pretreating proteinase K to be freeze dried, performing pre-freezing treatment on the proteinase K, then heating to a second temperature to quickly drying for the first time and then heating temperature to a third temperature to desorption drying; then reducing pressure, cooling to the second temperature, then haeting to the third temperature and performing special technologies of secondary drying and desorption drying. Compared with the prior art, freeze drying time of the proteinase K freeze drying technology is shortened to 20 to 26 hours; furthermore, a freeze dried product prepared in the proteinase K freeze drying technology has appearance shape meeting a standard, can redissolve quickly and has good stability; proteinase K activity cannot decrease after the proteinase K is stored in normal temperature for many years.

The invention discloses a preparation method of rapidly sintered porous ceramic, which comprises the following steps: 1, weighing a ceramic main material and additives such as an adhesive, and uniformly mixing to form a mixture; 2, treating the mixture obtained in the step 1 to form a solid mixture or slurry; 3, filling a mold cavity with the solid mixture or slurry obtained in the step 2, and forming a green body through dry powder pressing or casting molding; and 4, firing the green body obtained in the 3, setting the firing air pressure to be 10<-3>-10<5> Pa and the temperature to be lower than 1000 DEG C, and thus obtaining the porous ceramic. The air pressure condition of 10<-3 >-10<5> Pa is set in the firing process in the porous ceramic preparation process, so that the firing process is completed within 4 hours at the temperature of lower than 1000 DEG C, the bending strength of the porous ceramic is ensured and even improved while the firing period is shortened, and the oxidation of the main material is inhibited.

The invention provides electroluminescent phosphor having superior luminance and a long life. The host material is ZnS.aAO, of which “A” is at least one element selected from among magnesium (Mg), calcium (Ca), strontium (Sr), and barium (Ba). “a” ranges from 0.001 to 0.01. Either one of or both copper (Cu) or manganese (Mn) is contained as an activator. At least one element selected from among chlorine (Cl), bromine (Br), iodine (I), and aluminum (Al) is contained as a co-activator. The luminance and life span of the electroluminescent phosphor can be increased by limiting “a”, which represents the proportion of alkaline earth metal oxide (AO) introduced into the zinc sulfide, within the range of 0.001 to 0.01.

The invention provides a preparation method of roxatidine acetate hydrochloride for injection. The preparation method includes: using roxatidine acetate hydrochloride as raw material and glycine, mannitol, sodium sulfite and edetate disodium as auxiliary materials to prepare liquid medicine, performing ultrafiltration on the liquid medicine, and freeze drying the liquid medicine to prepare a freeze-drying preparation. The prepared roxatidine acetate hydrochloride for injection is applicable to upper gastrointestinal hemorrhage caused by gastric ulcer, stress ulcer and hemorrhagic gastritis and preanesthetic medication. The preparation method has the advantages that the stability of the roxatidine acetate hydrochloride solution for injection is increased, the related substances of the roxatidine acetate hydrochloride for injection are evidently reduced during preparing, split charging and freeze drying, evident content change is avoided, and the prepared roxatidine acetate hydrochloride preparation for injection is good in stability during transportation and storage; the preparation method is simple in process, low in energy consumption and convenient to operate, and the roxatidine acetate hydrochloride preparation prepared by the method is good in quality, definite in curative effect and stable in quality.

The invention relates to a preparation method of shuanghuanglian freeze-dried powder for intravenous injection, and aims to solve the problems of long drying time, high cost and low efficiency, which prevail in conventional preparation method of the shuanghuanglian freeze-dried powder. The method comprises the following steps: decocting and filtering forsythia, honeysuckle and scutellaria baicalensis, alcohol washing, water washing, still standing, and obtaining shuanghuanglian extractive; blending the extractive, filtering, carrying out spray freeze drying, and obtaining. Compared with the conventional freeze-drying, the method provided by the invention can reduce more than 50% time, greatly reduce the production cost, and improve the production efficiency. The invention is applied to the field of shuanghuanglian freeze-dried powder preparation.

The invention discloses Corydalis saxicola Bunting total alkaloid injection and a preparation method thereof (including water injection, powder injection and transfusion). The Corydalis saxicola Bunting total alkaloid injection is prepared by the given method through addition or no addition of auxiliary materials into Corydalis saxicola Bunting total alkaloids prepared by the given method. The product of the Corydalis saxicola Bunting total alkaloid injection has a better treatment effect, a simple preparation technique, and good market prospect and social benefit.

The invention provides a heatproof lyoprotectant for a live vaccine against pseudorabies. The heatproof lyoprotectant comprises, by weight, 3 to 10 parts of gelatin, 1 to 5 parts of trehalose, 5 to 15 parts of sucrose, 0.1 to 2 parts bovine serum albumin, 1 to 8 parts of tryptone, 2 to 10 parts of enzyme-hydrolyzed casein, 1 to 5 parts of thiourea, 0.8 to 2 parts of L-monosodium glutamate, 0.1 to 3 parts of arginine, 0.5 to 5 parts of polyvinylpyrrolidone (PVP-K30) and 0.1 to 2 parts of mannitol. The invention also discloses a preparation method of the heatproof lyoprotectant and a lyophilized vaccine prepared from the heatproof lyoprotectant. When the heatproof lyoprotectant is used for protecting the vaccine and a specific lyophilization process is employed, lyophilization loss of viruses can be effectively reduced, the temperature tolerance of the viruses can be improved, and the vaccine can still maintain good physical properties and titer after long-term storage; i.e., the vaccine has stable characters and has the characteristics of heat resistance and long storage time.

The invention discloses green and environment-friendly carbon dioxide waste gas recycling equipment and relates to the technical field of carbon dioxide waste gas recycling. The equipment comprises a freezing box and a breeding greenhouse, the freezing box is located on the left side of the breeding greenhouse, and an air inlet is formed in the left side wall of the freezing box. According to the equipment, excessive industrial carbon dioxide is compressed and collected through a dry ice compression device every time, and the situation that carbon dioxide continuously discharged into the breeding greenhouse cannot be completely used and is lost is avoided. When carbon dioxide needs to be added, through cooperation of a push plate and a push rod in the moving process of a telescopic air cylinder, the compressed carbon dioxide is ejected into the breeding greenhouse, the carbon dioxide impacts a cross-shaped rotating plate, a protective net cover is allowed to fall down to be in butt joint with a material receiving net disc, solid carbon dioxide is protected, the cross-shaped rotating plate stirs the solid carbon dioxide to rotate, and carbon dioxide gas is continuously released. Therefore, the concentration of carbon dioxide gas in the breeding greenhouse is increased for photosynthesis of plants.

The invention discloses a method for reducing the antiseptic residue in the extract of ginseng, ginseng leaf, ginseng stem, and ginseng fruit. The technology is characterized by comprising the following steps: oxidizing ginseng pulp, subjecting the ginseng pulp to a fresh-keeping treatment, disinfecting, alkalizing, soaking in hot water, extracting, separating, condensing, diluting, separating, condensing, and drying; alkalizing the ginseng, ginseng leaf, and ginseng stem, washing, extracting, separating, condensing, diluting, separating, condensing, and drying. The antiseptic is alkalized and decomposed by sodium carbonate; the ferrous sulfate is taken as the flocculant to remove the color, metal ions, and salt-type antiseptics; macroporous absorption resin absorbs the effective component and does not absorb the antiseptic, thus the water-soluble antiseptic is separated; the anion / cation resin is used to separate and remove the salt-type antiseptics; the solution is evaporated and condensed for two times, during the process the antiseptics are evaporated with the water steam; and during the drying process, because benzoic acid can rapidly sublimate at 100 DEG C, the antiseptic (benzoic acid) is quickly sublimated. Through the provided method, people can obtain products with complete active components, the antiseptic residues in the products are extremely low, or the products even contain no antiseptic residue.

The invention relates to the technical field of movable carriers, and discloses a movable carrier with a portable vehicle-mounted refrigerating device, the movable carrier comprises a movable carrier, a storage chamber, a refrigerating chamber and a refrigerating chamber are sequentially arranged in the movable carrier from left to right, and the interior of the refrigerating chamber is movably connected with a storage box. According to the mobile carrier with the portable vehicle-mounted refrigerating device, the storage chamber and the refrigerating chamber are arranged in the mobile carrier, normal-temperature storage and refrigerated storage of goods are facilitated, the reliability of the goods during transportation is effectively improved, refrigeration is conducted through dry ice arranged in the storage box, high refrigerating capacity can be obtained, and then air in the refrigerating chamber is circularly controlled by arranging the starting fan and the electromagnetic control valve, sublimation of dry ice can be accelerated, utilization of electric energy is effectively reduced, carbon dioxide generated by hydrogen production from methanol is changed into dry ice, the cost is greatly reduced, and the effect of low transportation cost is achieved.

An apparatus and method improves heating of a solid precursor inside a sublimation vessel. In one embodiment, inert, thermally conductive elements are interspersed among units of solid precursor. For example the thermally conductive elements can comprise a powder, beads, rods, fibers, etc. In one arrangement, microwave energy can directly heat the thermally conductive elements.

The invention relates to a tetramethylpyrazine phosphate liposome drug and a preparation method; wherein, the drug is characterized in that: the effective efficacy components and weight accounts of the liposome drug are as following: a mixture 200 to330 with a weight ratio 4 to 1 of egg yolk lecithin and sheep cerebral lecithin, a mixture 170 to 280 with a weight ratio 3 to 1of stigmasterol and campestrol, reduction glutathione 2.5 to 10, tetramethylpyrazine phosphate 15 to 25, a mixture 720 to 1200 with a weight ratio 1 : 0.01 to 0.05 : 0.02 to 0.07 of tert-butyl alcohol, ethanol, acetone, amixture 140 to 160 with a weight ratio 4:05 to 1 of polyethylene glycol-2000 and tween 801, and hydroxyl propyl methyl cellulose 100 to 120. The invention also provides the preparation method for theliposome drugs. The invention has the advantages of adopting the provided drugs, enabling to decrease the drug dosage by two third and once a day, and improving the efficacy above fifteen percent.

The invention relates to a novel thermal barrier coating preparation process, which comprises the following steps: forming a metal bonded underlayer on the surface of a substrate; forming an in-situ thermally grown oxide layer (TGO); and forming a ceramic heat-insulating surface layer. The TGO layer is pre-grown before the substrate is put into service. The composition of the TGO layer includes alpha-alumina. In the present invention, a layer of dense and continuous TGO layer mainly composed of α-alumina is preset through large-particle dry ice jet purification and roughening treatment and pre-vacuum argon oxidation treatment. The oxide film will have good resistance to high temperature oxidation, prevent rapid oxidation, reduce the growth rate of TGO layer thickness, and achieve the purpose of reducing the occurrence probability of thermal barrier coating peeling.

The invention belongs to the technical filed of material transportation packaging, and particularly discloses a frozen material transportation packaging box. The frozen material transportation packaging box comprises a packaging box body and a frozen module. Sliding grooves are symmetrically formed in the two side walls of the packaging box body, a supporting plate is slidably connected to the twosliding grooves, and cylinders are symmetrically arranged in the sliding grooves. The frozen module comprises two fixed boxes, a water tank and a dry ice bag, the two fixed boxes are symmetrically arranged, one ends of the fixed boxes communicate with the cylinders, racks are arranged in the fixed boxes, first telescopic springs are arranged on the outer parts of the racks, one ends of the racksare fixedly connected with pistons, and the other ends of the racks extend to the outer parts of the fixed boxes and are connected with a gear in a meshing mode; and the bottom of the gear is connected with a first bevel gear through a first rotating shaft, a clutch is arranged on the outer part of the first rotating shaft, and the first bevel gear is connected with a second rotating shaft in a meshing mode through a second bevel gear. A fan is arranged at one end of the second rotating shaft, the second rotating shaft is driven by a motor, the water tank is located at a position below the fixed boxes, and a controller is arranged on the outer part of the packaging box body.