57results about How to "Long-lasting activity" patented technology

The present invention provides one kind of soil repairing solid compound microbe microball and its preparation process. The soil repairing solid compound microbe microball is prepared with calcium alginate as embedding material and solid calcium carbonate as solid pore-creating agent to embed petroleum hydrocarbon degrading fungi, bacteria and nutritive matter, and the preparation process includes suspension preparation, microball formation, eliminating pore-creating agent and other steps. The present invention has the advantages of solid carrier maintained, has super large pores for reinforced mass transfer and embedded fungi, bacteria and nutritive matter, and thus possesses the advantages of high mass transferring speed, protection, nourishing, high activity and stability, etc. This kind of solid compound microbe microball may find its wide application in the biological repair of petroleum polluted soil.

A pharmaceutical composition comprising: (a) a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; R2 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; and R3 is hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, or O—C1-4-alkylene-COO—C1-4-alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.

The invention relates to a probiotic preparation and a preparation method thereof. The probiotic preparation is prepared from the following raw materials by weight: 28-75 parts of dietary fibers and 2-30 parts of probiotics, wherein the weight ratio of the dietary fibers to the probiotics is (1-10): 1. The activity of the probiotics is 0.3*10<10> CFU / g to 4*10<10> CFU / g. The invention further provides an equivalent incremental mixing method for preparing the probiotic preparation. Dietary fibers in the preparation provide protective sites for probiotics, so that the activity of the probioticscan be kept for a long time, the optimal active state can be kept under the conditions of production, transportation and the like, and the corresponding probiotic preparation can effectively regulateintestinal flora balance and maintain intestinal health, and has the effects of preventing and treating constipation and diarrhea.

The invention relates to a compound microbial preparation for inhibition of anaerobic fermentation over-acidification of vegetable wastes. The compound microbial preparation includes bacillus subtilis, bacillus cereus, bacillus megaterium, bacillus licheniformis, pichia pastoris, and saccharomyces cerevisiae. In an anaerobic fermentation environment, the microbial preparation has abilities of both producing alkaline substances and decomposing organic acids, can maintain acid-base balance of a vegetable waste anaerobic fermentation system, is well suitable for wet and dry anaerobic fermentation with the vegetable wastes as raw materials, and can guarantee smooth implementation of a biogas production process.

The invention relates to a wine and a preparation method thereof, and in particular relates to a wine containing an SOD (Superoxide Dismutase) component and a preparation method thereof. The preparation method of the wine containing the SOD component comprises the following steps of: (1) preparing phyllanthus emblica wine juice; (2) preparing phyllanthus emblica fermenting juice; (3) blending and disinfecting; and (4) bottling and packaging. The prepared wine per liter contains 800-1200 thousand international units of SOD. The original anthocyanin in percentage by weight in the wine is 0.01-0.0375%. The wine containing the SOD component prepared by the preparation method not only maintains taste of wine, but also increases various nutritional substances and SOD, and has the edible, beautifying and health-care functions.

The invention provides an antibacterial damage repair microneedle for slowly releasing MSC (mesenchymal stem cell) sourced exosome. The microneedle comprises a substrate and a microneedle unit fixed to the substrate, wherein the substrate is a soluble high-molecular polymer doped with silver nitrate, and the microneedle unit is a biodegradable material loaded with the MSC sourced exosome. According to the invention, a PDMS mold prepared with an etching technology is adopted to construct the damage repair microneedle with the microneedle unit loaded with MSC-exo and a substrate containing antibacterial metal nanoparticles, and after the damage repair microneedle acts on the skin, the MSC-exo can be slowly released to play anti-inflammatory and immunomodulatory roles, accelerate angiogenesisand improve the oxidative inflammation environment of the wound surface; meanwhile, the antibacterial metal nanoparticles in the substrate have the effect of preventing and treating bacterial infection, chronic wound healing of the skin is accelerated, the minimum treatment dosage of the MSC-exo and the antibacterial metal nanoparticles can be achieved in situ, and painless, safe and autonomous administration is achieved; and the preparation process is simple, large instruments are not needed, the medicine carrying capacity is high, safety and practicability are high, and popularization is easy.

The invention discloses an application of tetrahydrobenzene difenoconazole to preparation of an agricultural fungicide or fungicide composition and a preparation method of the tetrahydrobenzene difenoconazole, and further discloses an application of a 4-((-(2-chlorine-4-(4-chlorophenoxy) phenyl)-4-methyl-1, 3-dioxolane-2-base) methyl)-4H-1, 2, 4-triazole (tetrahydrobenzene) compound to agricultural fungicide. The structural formula of the compound is as shown in the specification. According to the application, 35-40% of tailings serving as hazardous organic waste solids in the production process of agricultural fungicide difenoconazole are changed into useful pesticides, emission of the hazardous organic waste solids is greatly decreased, and environmental protection pressure of production enterprises is relieved. According to the preparation method, the yield of the difenoconazole can be increased, and cost is reduced.

The invention discloses a soil restoration agent with a heavy metal pollution treatment function and a fertilizing function and a preparation process of the soil restoration agent. The soil restoration agent is mainly prepared from the following raw materials in parts by weight: 260 to 310 parts of organic fertilizer, 25 to 31 parts of microbial agent, 0.03 to 0.07 part of difenoconazole, 0.05 to 0.1 part of pyrethrum, 0.03 to 0.09 part of rotenone, 0.04 to 0.08 part of chlorothalonil and 0.02 to 0.06 part of lactobacillus plantarum. The organic fertilizer is used as a main raw material, the microbial agent, insecticidal and sterilized vegetable drug and chemicals capable of alleviating the harm of soil heavy metal are added, so that not only can the fertilizer effect of the soil be improved, but also the soil restoration agent can enter the soil deeply to improve the heavy metal pollution and prevent the disease and insect pests.

The invention provides a preparation method of PD1-knockout chimeric antigen receptor T cell targeting ROR1. The method comprises: linking an encoding gene of the chimeric antigen receptor CAR-ROR1 toa vector, and constructing the recombinant lentivirus, performing transfection on CD3 positive T lymphocytes, and performing knockout of the PD1 gene of the transfected T cells to obtain the PD1-knockout chimeric antigen receptor T cell targeting ROR1. The knockout of the PD1 gene by the chimeric antigen receptor T cell is in favor of amplification of T cells in the patient, and avoids the escapeof immunosurveillance of the tumor cells, the T cell has the performance of killing tumor cells with high efficiency and specificity, which maintains the viability and lethality of the cells for a long time and does not cause damage to normal cells.

The invention relates to the technical field of cosmetics, in particular to skin deep layer restoration liquid containing chelating bioactive factors and a preparation method thereof. The skin deep layer restoration liquid containing chelating bioactive factors is characterized in that bioactive factors are subjected to salinization treatment, the bioactive factors treated by salinization are then chelated with chelating agents, and the bioactive factors chelated with the chelating agents are next dispersed into aloe raw liquid, sodium hyaluronate and allantoin to form the skin deep layer restoration liquid. The skin deep layer restoration liquid has the obvious characteristics that after the salinization chelating of the bioactive factors, the aloe raw liquid is further used for protection; the activity maintaining time is long; in addition, the restoration effect can be easily generated through the cuticle; the generation of fibroblast and the generation of collagen are promoted; the skin elasticity is improved; the wrinkles are eliminated.

The invention discloses a method for preparing antibacterial functional cellulosic fibers. The method comprises the steps of using a cross-linking agent for enabling cyclodextrin to be arranged on the cellulosic fibers in a stem grafting mode through a chemical reaction, then utilizing the cyclodextrin on the fibers to conduct clathration on antibacterial agents, and in the preparing process, conducting ultrasound pretreatment on a reaction system comprising the cyclodextrin, the cross-linking agent, a catalyst and the cellulosic fibers. According to the method, the defect that in the prior art, the solid loading efficiency of the cyclodextrin is low, the preparation time is short, the efficiency is high, the antibacterial and anti-infection functional cellulosic fibers with the slow-release performance and paper products of the cellulosic fibers can be manufactured, and the functional cellulosic fibers have good market prospects.

The invention relates to the technical field of cosmetics, in particular to a Cu, Zn-rh SOD cosmetic composition for removing freckle, whitening skin and resisting wrinkles. The cosmetic composition comprises the following components by mass percent: 50-80% of emulsion matrix, 10-30% of a Chinese herb extract, 1-3% of skin penetration enhancer, 1-5% of an enzyme activity protective agent, and 100% of 100-1,000 u / g Cu, Zn-rh SOD and deionized water. The Chinese herb extract comprises the following Chinese herbal medicines in parts by weight: 1-5 parts of saffron crocus, 2-8 parts of salvia miltiorrhiza, 5-10 parts of liquorice, 3-6 parts of emblic leafflower fruit, 2-5 parts of white poria, 1-8 parts of radix ampelopsis and 1-5 parts of angelica sinensis. The cosmetic composition can remove freckles and colored spots on the skin to enable the skin to be relatively fine, smooth, white and resilient, meets the daily skin-care requirements of face skin whitening, freckle removing and wrinkles resisting of people, and is a novel safe high-quality cosmetic.

Remedies for dry eye and diseases associated with dry eye which contain as the active ingredient peptides represented by the general formula (I): H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-X1-Gln-X2-Ala-Val-X3-X4-Tyr-Leu-X5-X6 (I) wherein X1, X3 and X4 represent Lys or Arg, respectively; X2 represents Met, Leu or nLeu; X5 represents a chemical bond, Asn, Asn-Ser, Asn-Ser-Ile, Asn-Ser-Ile-Leu or Asn-Ser-Ile-Leu-Asn-X7 (wherein X7 represents a chemical bond, Gly, etc.); and X6 represents -OH or -NH2, or pharmaceutically acceptable salts thereof.

The invention discloses a method for extracting superoxide dismutase from plants as a raw material. By utilizing the characteristic of combining zinc and protease, the superoxide dismutase in plant wall broken active liquid is activated and extracted, and thus, ideal superoxide dismutase is obtained. According to the extraction method disclosed by the invention, the cost is low, the process is simple, the operation is convenient and practical, and the extracted superoxide dismutase is high in activity, good in quality and long in activity retention time and can be directly applied to filling raw materials of nutrients, healthcare products, drugs or foods.

The invention discloses a soil remediation agent for treating heavy metal contaminated soil. The soil remediation agent is prepared from, by mass, 260-310 parts of organic fertilizer, 25-31 parts of microorganism bacterium agent, 0.03-0.07 part of difenoconazole, 0.05-0.1 part of pyrethrum, 0.03-0.09 part of trifoliate jewelvine roots or stems, 0.04-0.08 part of chlorothalonil and 0.02-0.06 part of lactobacillus plantarum. According to the soil remediation agent for treating the heavy metal contaminated soil, the organic fertilizer serves as the main raw material, the microorganism bacterium agent capable of reducing soil heavy metals and the vegetable drug and chemicals capable of killing insects and achieving sterilization are added, not only can the soil fertilizer efficiency be improved, but also the soil remediation agent can penetrate into the soil, heavy metal contamination is improved, and diseases and insect pests are prevented and treated.

The invention provides drinking type yoghourt and a preparation method thereof, belonging to the technical field of yoghourt preparation. According to the technical scheme, the drinking type yoghourt comprises the following raw materials in parts by weight: 5-7 parts of plant extract, 80-85 parts of raw milk, 1-2 parts of longan powder, 0.5-1 part of nutmeg powder, 1-2 parts of whey protein powder, 7.5-8.5 parts of white granulated sugar and 0.3-0.4 part of citrus fibers. The invention also provides a preparation method of the yoghourt. The invention has the beneficial effects that the drinking type yoghourt is rich in mouthfeel and moderate in thickness, the original nutritional ingredients can be kept, and the lactic acid bacteria activity has long retention time. Moreover, the number of intestinal probiotics is increased, the intestinal environment is improved, the drinking type yoghourt particularly contains scientific components and can achieve the effects of lowering lipid and improving immunoregulation and is designed particularly aiming at sub-health population, and the sub-health problems of people are obviously improved.

The invention discloses a process for producing exopolysaccharides by fermentation of immobilized lactobacillus plantarum. The process comprises the following steps: (1) activating lactobacillus plantarum; (2) immobilizing cell agar; (3) fermenting the immobilized cell; (4) separating solid from liquid; (5) removing protein; (6) settling polysaccharides; and (7) lyophilizing. According to the method, the exopolysaccharides are produced by fermenting the immobilized lactobacillus plantarum, cells can be uniformly dispersed in hydrogel beads to durably keep the strain vitality and intracellularenzyme active state; the strain is protected from influence of acid, alkali, harmful ions and other disadvantageous conditions, and sustainable production can be performed; the immobilized particles are favorable to simplifying strain activity and product extraction process. Therefore, the immobilized particles can be used repeatedly, so that the strain utilization rate can be effectively improved, the production cost can be reduced, and high-yield and continuous industrial production of lactic acid bacteria exopolysaccharides becomes possible.

A pharmaceutical composition comprising:(a) a compound of formula 1wherein:n is 1 or 2;R1 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl;R2 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; andR3 is hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, or O—C1-4-alkylene-COO—C1-4-alkyl,or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and(b) another active substance 2,wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.

The present invention relates to a method for freezing a water-containing quantity of a biological entity or a formulation in a vessel using a mineral nucleator, to the use of the mineral as a nucleator and to a vessel with the mineral in or on the whole or part of a surface thereof.

The invention discloses a method for preparing cordycepin by fermenting cordyceps militaris through a calcium alginate freeze-dried network scaffold, and belongs to the field of biochemical engineering and food additives. The preparation method provided by the invention comprises the steps: (1) after cordyceps militaris spores are treated and activated through a plasma treater, a sodium alginate solution is added, even stirring is conducted, and the mixture is freeze-dried into a 3d scaffold; (2) the 3d scaffold is soaked through a calcium chloride solution, negative-pressure flash explosion is conducted, then vacuum drying is conducted, and the cordyceps militaris fermented network scaffold is prepared; and (3) columns are mounted on the cordyceps militaris fermented network scaffold andsoaked through a transformation original solution, and a cordycepin transformation solution is collected. The preparation method of the cordycepin is high in transformation efficiency, the preparationprocess can be continuously conducted, and industrialization promotion is facilitated.

The invention provides a skin care composition for rapid absorption which comprises the following raw materials (by weight percent): stearic acid 5-7%, C16-18 alcohols 3-4%, Ceteareth-25 1-3%, Ceteareth-6 1-3%, glyceryl stearate 3-5%, isopropyl myristate 3-5%, caprylic / capric triglyceride 4-6%, glycerol 4-6%, azone 0.5-0.7%, mixed grease liposome 10-20%, safflower 5-7%, hydroxyethyl cellulose 0.1-0.3%, and aluminium magnesium silicate 0.1-0.3%.

The invention discloses industrial zirconium carbonate with high purity, good activity and good storage stability, and a preparation method thereof, and belongs to preparation methods of zirconium compounds. The product quality of the industrial zirconium carbonate with high purity, good activity and good storage stability reaches the following standards: the particle size D50 ([mu]m) is 35-40, the activity retention time is larger than or equal to 24 months, the ZrO2 content is larger than or equal to 42 wt%, and the impurity content is lower than a current national standard. The invention provides the zirconium carbonate product, which has a high ZrO2 content, a long activity retention time, and a wide range of the mass ratio of zirconium carbonate to ammonium bicarbonate, is applicableas a raw material with a short reaction time for synthesizing a zirconium carbonate water-repelling crosslinking agent, and can also meet demands for preparation of the zirconium carbonate crosslinking agent required for automobile exhaust ternary catalysis purifier carrier materials and aqueous coating adhesives. The invention provides the preparation method for the industrial zirconium carbonatewith high purity, good activity and good storage stability, wherein the preparation method is easy for filtering operation, and the product content is high. According to the technical scheme, the production cost is reduced, raw materials are saved and environmental protection is facilitated.

The invention provides a strain screening method with efficient desulfurization and denitrification activities simultaneously and belongs to the technical field of biology. The method comprises the following steps: primary screening in the first step, purification and separation in the second step, biochemical culture in the third step and multiplication culture in the fourth step. According to the screening method provided by the invention, by setting screening and culturing conditions, strains with relatively high desulfurization and denitrification activities can be obtained. For strains obtained by adopting the screening method, the sulfide degradation efficiency is higher than 99%, and the ammonia nitrogen degradation efficiency is higher than 70%. The strain can save water treatment facility investment, ensure the sewage treatment effect, reduce investment for chemical treatment and energy consumption, and lower the sewage treatment cost, which is at least lowered by 0.20 yuan / cubic meter, has no secondary pollution, and can finally eliminate the influence to surrounding water environment and atmospheric environment; furthermore, the strain can be applied to treatment of petrochemical wastewater and domestic sewage, and has good environment and social benefits.

The present invention relates to a stable antiseptic solution comprising: a di(4-chlorophenyldiguanido) compound or a pharmaceutically acceptable salt thereof, wherein said di(4-chlorophenyldiguanido) compound or a pharmaceutically acceptable salt thereof is a compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to a process for preparing said antiseptic solution.

The invention provides application of a molecular allosteric body and dimer of a human growth hormone releasing hormone (hGHRH) similar peptide in treating GH deficiency, infertility, senile dementiaand diabetes and enhancing immunity. The dimer is formed by connecting two identical hGHRH similar peptide monomers containing a single cysteine molecule allosteric structure through a disulfide bondformed by cysteine, and an H-shaped structure (intramolecular single Ser-to-Cys substitution) is formed. A side chain epsilon-amino of one lysine of the GHRH similar peptide is also subjected to fattyacid chain modification. Through fatty acid modification, the GH sustained release time of the GHRH similar peptide monomer or dimer is prolonged in vivo, and the longest release time reaches 17 days. The invention finds that the GHRH dimer with long-acting activity has an Aib-to-2Ala substitution structure, an 18C-to-18C disulfide bond formation structure, a C20 fatty acid chain modification structure and a C-terminal amidation structure.

The invention relates to a retarder composition for the control of unwanted polymerisation reactions during the production and processing of ethylenically unsaturated compounds, the composition comprising at least one di-substituted quinone compound and at least one hydroxylamine compound. Optionally, the composition also comprises at least one stable free radical nitroxyl compound and one or more formulation adjuvants. The invention also envisages a process stream comprising at least one ethylenically unsaturated compound, and a method for the prevention of unwanted polymerisation reactions during the production and processing of ethylenically unsaturated compounds. The composition has been found to be far more effective than expected, given that the individual components show little or no efficacy when used alone, and poses much less hazard to humans than the compositions of the prior art.

The invention relates to the field of deer blood crystals, and particularly discloses a deer blood crystal production process and a deer blood crystal solid composition. The invention relates to a deer blood crystal production process, which comprises: taking fresh deer blood, adding beta-cyclodextrin into the deer blood according to the weight of the beta-cyclodextrin accounting for 1-2% of the weight of the deer blood, and carrying out slow stirring so as to uniformly mix the beta-cyclodextrin with the blood to obtain a primary product; and sequentially carrying out pre-freezing, primary drying and secondary drying on the primary product to obtain the deer blood crystal. The deer blood crystal solid composition comprises the following components in parts by weight: 95-100 parts of deer blood crystals and 5-10 parts of trehalose. The deer blood crystal production process provided by the invention has the advantages that the operation is simple, and the prepared deer blood crystal has better stability; in addition, the deer blood crystal solid composition disclosed by the invention has the advantages of long storage time, lasting activity and health-care efficacy.

The invention relates to aschersonia oil and compounded insecticide containing same and nitenpyram. The aschersonia oil includes, by weight, from 30 to 50% of aschersonia pure spore powder, from 15 to 40% of solvent oil, from 2 to 20% of food-grade emulsifying agent, from 2 to 40% of adsorbent, from 2 to 20% of ultraviolet absorbent and from 2 to 20% of antioxidant. The oil can prolong the storage period of spore and increase absorptivity of the spore. The aschersonia preparation can be used independently, can also be used with other chemical insecticides, and has the advantage of high insecticide ability when used with the nitenpyram. The aschersonia oil is diluted by nitenpyram aqueous solution, and the dosage of the nitenpyram does not exceed 10% of conventional dosage of the nitenpyram used in fields. The preparation method is simple, and a product has quite high effect of killing injurious insects including aleyrodid, aphid and the like, and plays an important role in preventing and killing farming and forestry pests.

The invention discloses a soil remediation agent with the heavy metal pollution treatment and fertilization effects and a preparation method thereof.The soil remediation agent is mainly prepared from, by mass, 260-310 parts of organic fertilizer, 25-31 parts of a microbial agent, 0.03-0.07 part of difenoconazole, 0.05-0.1 part of pyrethrum, 0.03-0.09 part of derris, 0.04-0.08 part of chlorothalonil and 0.02-0.06 part of lactobacillus plantarum.According to the soil remediation agent, the organic fertilizer serves as a main raw material, the microbial agent capable of reducing heavy metal in soil and the plant pesticides and chemicals capable of killing pests and bacteria are added, and thus the soil remediation agent can improve the fertilizer effect of soil and can also penetrate deep into soil to relieve heavy metal pollution and prevent and treat pest and disease damage.