The invention belongs to the field of metal materials and discloses a large-thickness and high-strength quenched and tempered steel plate and a production method thereof. The steel plate mainly consists of the following chemical components by weight percentages: not more than 0.18% of C, 0.1-0.4% of Si, not more than 1.2% of Mn, 0.7-1.7% of Ni, 1.0-1.5% of Cr, 0.4-0.6% of Mo, 0.03-0.08% of V, 0.02-0.04% of Al, 0.0005-0.0020% of B, Fe and unavoidable impurities. The molten steel designed according to the components of the invention can be rolled into the large-thickness steel plate by smeltingprocess, casting process, heating process, rolling process, water cooling process and quenching and tempering process. The steel plate has the advantages of reasonable component design, good comprehensive properties and low production cost, can be applied to off-shore oil production platform engineering, power stations, engineering scaffolds and other industries and has good application prospect.