The invention discloses an acetone gas sensitive material and a preparation method thereof. The material has the following structure: CuxZn (1-x) Fe2O4, x = 0.25-1, the copper-zinc mixed ferrite hollow sphere acetone gas sensitive material is prepared by adopting a one-step solvothermal method and high-temperature heat treatment, and the novel spinel structure gas sensitive material is successfully obtained by gradually replacing Zn ions with Cu ions. The preparation method is simple, efficient and safe, the cost is low, the practical application value is high, according to the gas sensitive material, cation redistribution is realized, a hollow structure is realized, compared with a zinc ferrite hollow ball, the mixed spinel structure gas-sensitive material and CuFe2O4 hollow spheres showmore excellent gas-sensitive performance on low-concentration acetone at a relatively low temperature (125 DEG C), including high sensitivity, quick response and excellent selectivity, and show a wideapplication prospect in the field of quick nondestructive detection of respiratory gas (acetone) of diabetic patients.