The invention discloses cereal diet meal replacement powder and a making method thereof. The cereal diet meal replacement powder includes raw materials yam, red dates, Chinese wolfberry fruits, oats, red beans, black beans, black sesame, walnut kernels, dried apples, chia seeds, quinoa and probiotics. The cereal diet meal replacement powder has the effects of moderating, nourishing and tonifying qi, nourishing the kidney, nourishing the blood, nourishing the intestines and detoxifying the intestines and expelling toxin, is suitable for all people, is homological in medicine and food, natural and health-care and can replace the three meals.