178 results about "Tosylphenylalanyl Chloromethyl Ketone" patented technology

The invention relates to a method for preparing (S)-(4-chlorphenyl)-(pyridine-2-yl)-methanol by utilizing microbial catalysis, and belongs to the technical field of biological catalysis. According to the method, 4-chlorphenyl-(pyridine-2-yl)-ketone is subjected to asymmetrical reduction by utilizing kluyveromycessp (CCTCCM 2011385) whole cells to synthesize the (S)-(4-chlorphenyl)-(pyridine-2-yl)-methanol. The method comprises the following steps of: sieving a microbe which has high-stereoselectivity carbonyl reductase activity on a prochiral ketone substrate, determining a series of conditions of asymmetrical reduction reaction, such as reaction temperature, pH, the concentration of cells, the concentration of the substrate and reaction time and additives (including various secondary solvents, polyethyleneglycol (PEG), phosphates and the like), wherein the enantiomer excess value and yield of the (S)-(4-chlorphenyl)-(pyridine-2-yl)-methanol serving as a product can reach 86.7 percent e.e and 92.1. The product is separated and extracted initially by silicagel column chromatography, so that the purity of the separated product is 99.2 percent, and the extraction yield is 56.7 percent.

A ultraviolet curing coating and its production are disclosed. The coating consists of filming substance, diluent and light initiating agent or assistants. The diluent is a organic solvent which comprises one of several from toluene, acetic ether, acetate butyrin, isobutyl acetate, propyl acetate, alcohol, n-butyl alcohol, ethylene ketone, dimethyl benzene, methyl isobutyl ketone, acetone, methyl ethyl ketone, ethanediol butyl ester and propylene butyl ester. It costs low, has better abrasive-resistance, hardness and adhesion.

The invention discloses a fingerprint resisting ultraviolet curing paint which mainly comprises the following components according to the mass percent: 25-28 of stain resisting low polymer, 4-6 of multifunctional-group aliphatic urethane acrylate, 5-6 of urethane acrylate, 22-25 of polymer modified acrylate, 25-30 of tri(propylene glycol) diacrylate, 15-18 trimethylolpropane methylacrylate, 4-5 of 1-hydroxycyclohexy phenyl ketone, 0.4-0.5 of stain resisting photo-curing assistant, 0.1-0.3 of flatting agent and 120-130 of diluting agent. The invention develops the fingerprint ultraviolet curing paint which has fingerprint resisting effect, easy cleaning of permanent pen marks and better oil stain resistance and is used for a PC board by adopting stain resisting low polymer as main resin and adding the stain resisting photo-curing assistant in the formulation, and solves the problems that common ultraviolet curing paint is easily stained by fingerprints, the permanent pen marks are not easy to remove and the stain resistance is poor.

The invention relates to optical activity di(heteto)aryl methanol and an asymmetric synthesis method thereof. The method comprises the following steps: taking mono-sulfonyl chiral diamine and a complex of metals ruthenium, rhodium and iridium as catalysts, taking sodium formate or formic acid/triethylamine or isopropanol as a hydrogen source, carrying out an asymmetric transfer hydrogenation reaction of di(heteto)aryl ketone first, thereby obtaining the optical activity di(heteto)aryl methanol. The method is mild in reaction conditions, easy and convenient to operate, readily available in raw materials, wide in substrate application range and high in enantioselectivity and has important application prospects in the aspects of synthesis of antihistamine chiral drugs such as diphenhydramine, methyldiphenhydramine, carbinoxamine and bepotastine.

The invention relates to an asymmetric synthesis method of an ophthalmologic drug pylistramine besylate. The method concretely comprises the following steps: oxidizing (4-chlorophenyl)(2-pyridyl)methanone to obtain (4-chlorophenyl)(2-pyridyl)ketone-N-oxide; carrying out asymmetric transfer hydrogenation reduction on the (4-chlorophenyl)(2-pyridyl)ketone-N-oxide through using a complex of monosulfonyl chiral diamine and metallic ruthenium, rhodium and iridium as a catalyst and a sodium formate or formic acid and triethylamine mixture or isopropanol as a hydrogen source in order to prepare (S)-(4-chlorophenyl)(2-pyridyl)methanol-N-oxide; reducing the (S)-(4-chlorophenyl)(2-pyridyl)methanol-N-oxide to prepare (S)-(4-chlorophenyl)(2-pyridyl)methanol; and condensing the (S)-(4-chlorophenyl)(2-pyridyl)methanol and ethyl 4-(4-bromopiperidine-1-yl)butyrate to obtain the ophthalmologic drug pylistramine besylate. The total yield is 61.6%.

The invention discloses fingerprint resisting UV light oil which mainly comprises the following components according to the weight portion: 30-35 of stain resisting low polymer, 5-6 of urethane acrylate, 15-18 of polymer modified acrylate, 15-18 of tri(propylene glycol) diacrylate, 25-30 trimethylolpropane methylacrylate, 4-5 of 1-hydroxycyclohexy phenyl ketone, 0.4-0.5 of stain resisting photo-curing assistant, 0.1-0.3 of flatting agent and 120-140 of diluting agent. The invention develops the fingerprint UV light oil which has fingerprint resisting effect, easy cleaning of permanent pen marks and better oil stain resistance and is used for an ABS+PC plastic piece by adopting stain resisting low polymer as main resin and adding the stain resisting photo-curing assistant in the formulation, and solves the problems that common UV light oil is easily stained by fingerprints, the permanent pen marks are not easy to remove and the stain resistance is poor.

The invention relates to a recoatable UV radiation cured coating for plastic as well as a production method and an application method of the coating. The recoatable UV radiation cured coating for the plastic comprises the following components in percentage by weight: 20-30% of tetrafunctional aliphatic polyurethane acrylate resin, 20-30% of bifunctional polyurethane acrylate resin, 8-15% of trimethylolpropane trimethacrylate, 15-25% of 1,6-hexanediol diacrylate, 2-5% of 1-hydroxy-cyclohexyl-phenyl ketone, 0.5-2% of diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide, 7-17% of a solvent, and 0.5-1% of reactive polysiloxane acrylate, wherein the solvent is a mixed solvent composed of at least two of ethyl acetate, butanone, butyl acetate, n-butyl alcohol and isopropanol. The UV radiation cured coating for the recoatable plastic disclosed by the invention can be directly repaired without integrally grinding and prespraying a layer of bottom water while being used normally.

The invention provides a UV curing high wear-resistant low luster coating and a preparation method thereof. The coating comprises the following components in percentage by weight: primer and a curingagent, wherein, the primer comprises 55-60 of hydroxyl acrylic resins, 10-13 of solution containing 20% of cellulose acetate butyrate resins, 4-6 of methyl isobutyl ketone, 0.1-0.2 of flow agent, 5-7of aluminum paste and 17-19 of ethyl acetate; the curing agent comprises 55-60 of hexamethylene diisocyanate, 10-15 of unsaturated aliphatic polyurethane acrylate and 26-32 of butyl acetate. The invention has the advantages as follows: the invention has low VOC discharge when being used for construction under common coating conditions; the invention can achieve the effects of high wear resistanceand difficult surface shining by using the common plastics coating method; the invention features simplicity and commonality of construction and has very good adhesion on the plastics and aluminum; the invention features thin film thickness and has cost lower than that of the common UV coatings.

The invention provides a stone surface crystallization UV photocurable coating, a method for preparing the same and a construction process. The stone surface crystallization UV photocurable coating comprises the following components: aliphatic polyurethane acrylate, trifunctional aliphatic polyurethane acrylate, thermoplastic acrylic resin, trimethylolpropane triacrylate, dipentaerythritol pentaacrylate, 1-hydroxy-cyclohexyl phenyl ketone, a photoinitiator, ethyl acetate, a leveling agent, a defoaming agent, butyl acetate and toluene. When the coating is used for the surface crystallization protection treatment of stones, because the photocurable technique is adopted, the film forming efficiency is 20 to 23 seconds, so that the film can be quickly formed in high efficiency, and the surface of the stones, on which the film is formed, is high in hardness, glossiness and saturation; and the coating can also improve chemicals resistant, acid resistant, alkali resistant, pollution resistant, heat resistant, ironing resistant, smoke and fire resistant, aging resistant properties and the like of the surface of the stones.

The invention belongs to the technical field of medicines and relates to (1-aryl-1H-pyrazol-4-yl)(3,4,5-trimethoxyphenyl)ketone and ketoxime compounds and an application thereof and exactly relates to the compounds and an application thereof to antitumor medicines as tumor cell proliferation inhibitors. A structure of the compounds is shown in a general formula I in the specification: the definition of each substituent is shown in the claim and specification.

A novel hydroxyalkyl phenyl ketone: (1-hydroxycylohexyl)[4-(2- hydroxy ethoxy)phenyl] methanone, its preparing process and its application as the trigger for optical solidification are disclosed. Said trigger can effectively and optical trigger the polymerization between unsaturated compound and resin. Its special molecular structure can prevent migration, odoring and yellowing.

The invention aims to solve the technical problems of an existing alpha-hydroxycyclohexyl phenyl ketone synthesis method, provides a synthesis method of a photoinitiator 1-hydroxycyclohexyl phenyl ketone, and belongs to the technical field of chemical synthesis. The synthesis method comprises the following steps: (1) reacting a halogenated benzene with magnesium particles to prepare a Grignard reagent, dropwise adding cyclohexylcarbonitrile into the prepared Grignard reagent, and after the reaction is completed, hydrolyzing to generate cyclohexyl phenyl ketone; and (2) reacting cyclohexyl phenyl ketone with chlorine to obtain 1-chlorocyclohexyl phenyl ketone, and carrying out a hydrolysis reaction on the 1-chlorocyclohexyl phenyl ketone and a sodium hydroxide aqueous solution under the action of a catalyst to obtain 1-hydroxycyclohexyl phenyl ketone. The method is simple in synthesis process, high in yield and suitable for industrial production.

The invention provides a dicarbazole compound containing a tetraphenylethylene structure as well as a preparation and application thereof. The name of the compound is as follows: 9,9'-(5-(2,2-diphenyl-1-(4-benzyl))vinyl-1,3-phenylene)dicarbazole. A preparation method comprises the following steps: firstly, preparing 3,5-di(9-carbazolyl)phenyl-(4-methylphenyl)ketone; then enabling the 3,5-di(9-carbazolyl)phenyl-(4-methylphenyl)ketone to react with diphenylmethane to obtain the 9,9'-(5-(2,2-diphenyl-1-(4-benzyl))vinyl-1,3-phenylene)dicarbazole. The compound provided by the invention has good thermal stability, electrochemical stability, charge transferring property and luminescent property and can be used as a blue-green organic electroluminescent material.