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326 results about "Sodium butyrate" patented technology

Sodium butyrate is a compound with formula Na(C₃H₇COO). It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression. As such, it can be used in lab to bring about any of these effects. Specifically, butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene in chromatin structure and function. Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes.

Antibiotic-free piglet conservation material and preparation method thereof

The invention relates to an antibiotic-free piglet conservation material and a preparation method thereof. The conservation material comprises the following raw materials of puffed corn, wheat, a base material, efficient cream, soybean meal, fermentation soybean meal, whey powder, composite yeast, rice protein powder, stone powder, calcium hydrogen phosphate, lysine, methionine, threonine, choline chloride, liquid phytase, liquid xylanase, a acidifying agent, sodium butyrate and a premix compound. The antibiotic-free piglet conservation material can increase immunity of the piglet, prevents the piglet from generating drug resistance and appearing drug residue problems, maintains stability of intestinal flora, and improves digestion and absorption for forage of the piglet.
Owner:河南商都生物技术股份有限公司

Creep mixed feed for piglets

The invention relates to a pig feed, in particular to a creep mixed feed for piglets. The creep mixed feed for piglets comprises the following raw materials in part by weight: 100 to 300 parts of puffed corn, 100 to 300 parts of rice meal, 100 to 300 parts of flour, 10 to 30 parts of soybean oil, 0.3 to 0.5 part of rovimix 536 compound vitamin, 2.5 to 4 parts of low-copper mineral element, 50 to 100 parts of peeled bean pulp, 30 to 80 parts of fermented bean pulp, 40 to 100 parts of puffed soybean, 30 to 50 parts of steam fish meal, 20 to 50 parts of slurry albumen powder, 20 to 30 parts of dried porcine solubles, 40 to 100 parts of whey powder, 20 to 40 parts of glucose powder, 20 to 40 parts of sucrose, 10 to 50 parts of emulsified fatty powder, 5 to 10 parts of calcium carbonate, 1 to 3 parts of table salt, 5 to 12 parts of calcium biphosphate, 1 to 2 parts of sodium butyrate, 1 to 5 parts of lysine, 0.5 to 3 parts of threonine, 1 to 4 parts of methionine, and 0.5-1 part of TP-100 enzyme. Nutrient components of a product simulate those of breast milk; the creep mixed feed for piglets has high palatability and digestibility; the piglets like eating the feed, so feed intake is large; the product increases the survival rate and the immunity of the piglets, and the piglets do not have loose bowels; and in the product, a process technique of supermicro milling and cold granulating is adopted, and the use ratio of the feed is increased.
Owner:江西大佑农生物科技有限公司

Clostridium butyricum having diarrhea treating effect and application of clostridium butyricum as substitute of sodium butyrate

The invention discloses a clostridium butyricum having a diarrhea treating effect. The strain is named as clostridium butyricum Cb-2 which is conserved in China Center for Type Culture Collection with the conservation number of CCTCC M2011384, in November 9th, 2011. A test proves that the clostridium butyricum disclosed by the invention has strong acid producing capability especially butyric acidproducing capability; and the clostridium butyricum has obvious effects on diseases, such as intestinal tract flora infection, acute and chronic diarrhea, irritable bowel syndrome and non-ulcer dyspepsia, caused by various reasons, and has no toxicity and harm. Thus, the clostridium butyricum or clostridium butyricum powder disclosed by the invention is used as a raw material for preparing a micro-ecological preparation and used for replacing sodium butyrate to be applied; and when a specific application is carried out, a clostridium butyricum preparation can be singly used as an active component to be prepared into the micro-ecological preparation together with corn starch, or, the clostridium butyricum preparation is mixed with at least one of other bacterial preparations and the corn starch to prepare a composite micro-ecological preparation.
Owner:山东宝来利来生物工程股份有限公司

Preparation method of microencapsulation diolame sodium butyrate

The invention relates to a preparation method of an animal feed additive microencapsulation diolame sodium butyrate. The method comprises the following steps of: mixing hydroxypropyl methyl cellulose, chitosan and silica, boiling at high temperature of 230DEG C in a fluidized bed; spraying sodium butyrate aqueous solution on a mixture of three materials; drying at a high temperature, solidifying at a low temperature, solidifying and molding sodium butyrate particles; dissolving a coated material Brazil palm wax, palm oil and polyethylene glycol into an organic solvent, carrying out bottom-spraying and coating in a fluidized bed to obtain the evenly-coated sodium butyrate particles of which the mass percent of the sodium butyrate is 30-70%. The microencapsulation process is carried out on feed grade sodium butyrate power to avoid the loss of sodium butyrate in poultry crop and pig stomach, so as to reach the rear section of small intestine and cover the whole intestinal tract, meanwhile, overcomes foul smell, prevents air slaking, and protects sodium butyrate from losing in the process of feed processing.
Owner:HANGZHOU KINGTECHINA FEED CO LTD

Methods for producing high titre vectors and compositions used in such methods

A method for producing viral vectors is described using packaging and producer cell lines is described. The producer cell comprises: (i) a first nucleotide sequence (NS) encoding a toxic viral envelope protein operably linked to a promoter; wherein the promoter is operably linked to at least one copy of a TRE; (ii) a second NS wherein the second NS comprises a sequence encoding a tetracycline modulator; (iii) a third NS encoding a retrovirus nucleocapsid protein; and (iv) a fourth NS comprising a retroviral sequence capable of being encapsidated in the nucleocapsid protein such that the retroviral vector particle titre obtainable from the producer cell is regulatable by tetracycline and an initial stimulus with sodium butyrate or functional analogues thereof.
Owner:OXFORD BIOMEDICA (UK) LTD +1

Child care pig compound feed without tensile body and preparation method thereof

The invention relates to child care pig compound feed without a tensile body, and the child care pig compound feed is prepared from the following components: corn, peeled soybean meal, puffed soybean meal, fermented soybean meal, steam white fish meal, flour, soybean oil, mountain flour, calcium hydrogen phosphate, edible salt, child car pig compound premix, coated slow-release acidifier, L-lysine hydrochloride, DL methionine, L-thronine, tryptophan, octanoic/decanoic acid glyceride, yeast nucleic acid, xylo-oligosaccharides, sodium glutamate, sodium butyrate, the root of Chinese pulsatilla, coptis chinensis, golden cypress, ash bark, choline chloride and phytase. The child care pig compound feed without the tensile body provided by the invention starts from the physiological characteristics of a child care pig, adopts multiple combinations of raw materials, is complementary in nutrition, designs amino-acid-balanced, calcium-phosphate-balanced and electrolyte-balanced daily ration, adds no antibiotic, adopts medium-chain fatty acid and natural Chinese herbal medicine additive for health protection, and can be used for improving food consumption of the child care pig, reducing the feed conversion ratio, improving intestinal health of the child care pig, improving immunity and drawing a skeleton of the child care pig, so that a good foundation is laid for later-stage growth.
Owner:HUAIAN ZHENGCHANG FEED

Weaned pig transition compound feed and preparation method of weaned pig transition compound feed

The invention discloses weaned pig transition compound feed, which comprises the following ingredients in parts by weight: 37 to 46 parts of corn, 0 to 19 parts of functional energy and protein feed, 5 to 10 parts of extruded soybean, 7.5 to 8 parts of shelled soybean meal, 8 to 12 parts of lactose, 2 to 3.5 parts of imported fish meal, 0 to 2 parts of concentrated soybean,0.5 to 0.6 parts of mountain flour, 0.71 to 1.8 parts of dicalcium phosphate, 0.9 to 1.1 parts of premix compound, 0.26 to 0.5 parts of lysine, 0.17 to 0.25 parts of methionine,0.2 to 0.3 parts of common salt, 0.24 to 0.26 parts of zinc oxide, 0.06 to 0.15 parts of threonine, 0.02 to 0.05 parts of tryptophan, 0.01 to 0.02 parts of sweetening agents, 0.1 to 0.12 parts of sodium butyrate, 0 to 0.4 parts of emulsifying agents, 0 to 2.5 parts of cane sugar, 0.1 to 0.12 parts of compound microorganism bacterium agents, 0 to 0.02 parts of flavouring agents, 0 to 0.2 parts of acidifying agents,0 to 2 parts of bean oil, 0 to 8 parts of whey powder, 0 to 15 parts of immuno-enhancers and 0 to 3 parts of plasma protein powder, wherein the compound microorganism bacterium agents comprise one kind of several kinds of lactic acid bacteria. The weaned pig transition compound feed provided by the invention is a key measure for ensuring the continuous growth of weaned piglets. Beneficial microorganisms are added into the weaned pig transition compound feed, the occurrence of diarrhea of the weaned piglets can be reduced, in addition, the digestion is easy, and piglets like to eat the feed.
Owner:BEIJING DABEINONG TECH GRP CO LTD +2

Joint production method for (S)-3-hydroxyl-gamma-butyrolactone, (S)-3-hydroxyl tetrahydrofuran

The present invention discloses a joint production method of (S)-3-hydroxyl-Gamma-butyrolactone and (S)-3-hydroxyl tetrahydrofuran. The production method comprises the following steps: firstly, L-malic acid is added into methanol, inorganic acid is added for catalysis, the solid is dissolved and reflows, and then is decompressed and dried through evaporation, the methanol and thionyl chloride are added, the reaction solution is heated and reflows, and the L-malic acid can be produced; secondly, the L-malic acid and tetrahydrofuran are mixed, a reducing agent and a catalyst are added for catalysis, and the (S)-1, 2, 4-trihydroxybutane aqueous solution and (S)-3, 4-hydroxy sodium butyrate are respectively produced; thirdly, water is vaporized from the (S)-1, 2, 4-trihydroxybutane aqueous solution, and the (S)-3-hydroxyl tetrahydrofuran is synthesized through catalytic ring closure, the pH of the (S)-3, 4-hydroxy sodium butyrate aqueous solution is adjusted, the (S)-3, 4-hydroxy sodium butyrate aqueous solution reflows, is dried through evaporation and extracted with ethyl acetate, and the (S)-3-hydroxyl-Gamma-butyrolactone can be produced. The present invention has the advantages that raw materials are cheap, the dosage of the thionyl chloride is reduced, and the production method has less environmental pollution.
Owner:CHANGMAO BIOCHEMICAL ENG CO LTD

Method for preparing pig neural stem cells by reprogramming

ActiveCN103740757AReproduce symptoms of neurological disordersNervous system cellsVector-based foreign material introductionNeurulationNeural cell
The invention discloses a method for preparing pig neural stem cells by reprogramming. The invention provides a method for preparing mammal neural stem cells by reprogramming. The method comprises the following steps: (1) commonly conducting gene OCT3 / 4, SOX2, KLF4 (Kruppel-Like Factor 4), LMyc and LIN28 into mammal somatic cells by using a non-integrated type episomal carrier to obtain transgenic cells; and (2) culturing the transgenic cells by using an induction culture system containing sodium butyrate to obtain the neural stem cells. An experiment shows that the non-integrated type episomal carrier is used for conducting factors including the OCT3 / 4, the SOX2, the KLF4, the LMyc, the LIN28 and the like into pig somatic cells; the somatic cells are transdifferentiated into the neural stem cells through optimizing a cultivation condition; the neural stem cells are further differentiated to obtain neural cells with physiological activity so as to lay foundation to nervous system diseases taking a pig as a model.
Owner:INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES

Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application

The invention discloses a feed additive with piglet stress resistance and intestinal tract improvement effects and a preparation method and application. The feed additive is composed of active components and matrix; the active components comprise 2-4 parts of lysine, 5-10 parts of taurine, 3.5-4 parts of cysteine, 6-12 parts of glutamine dipeptide, 5-10 parts of glucose, 6-12 parts of sodium butyrate, 2-3 parts of selenium yeast, 3-6 parts of vitamin A, 4-8 parts of vitamin E, 5-9 parts of vitamin C, 1-3 parts of N-carbamyl glutamic acid chelate copper, 1-3 parts of N-carbamyl glutamic acid chelate zinc and 1-3 parts of manganese methionine. The active components are uniformly mixed with the matrix to obtain the feed additive. The feed additive has the advantages that the piglet growth property can be effectively improved, the piglet gastrointestinal tract health and the stress resistance capability are improved, medical components are not contained, the cost is low, and the application prospect is wide.
Owner:FUJIAN AONONG BIOLOGICAL TECH GRP CO LTD +2
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