Clostridium butyricum having diarrhea treating effect and application of clostridium butyricum as substitute of sodium butyrate

Abstract

The invention discloses a clostridium butyricum having a diarrhea treating effect. The strain is named as clostridium butyricum Cb-2 which is conserved in China Center for Type Culture Collection with the conservation number of CCTCC M2011384, in November 9th, 2011. A test proves that the clostridium butyricum disclosed by the invention has strong acid producing capability especially butyric acidproducing capability; and the clostridium butyricum has obvious effects on diseases, such as intestinal tract flora infection, acute and chronic diarrhea, irritable bowel syndrome and non-ulcer dyspepsia, caused by various reasons, and has no toxicity and harm. Thus, the clostridium butyricum or clostridium butyricum powder disclosed by the invention is used as a raw material for preparing a micro-ecological preparation and used for replacing sodium butyrate to be applied; and when a specific application is carried out, a clostridium butyricum preparation can be singly used as an active component to be prepared into the micro-ecological preparation together with corn starch, or, the clostridium butyricum preparation is mixed with at least one of other bacterial preparations and the corn starch to prepare a composite micro-ecological preparation.

Description

technical field [0001] The invention relates to a Clostridium butyricum strain capable of treating diarrhea and its application as a sodium butyrate substitute. Background technique [0002] At present, with the continuous development of the economy and the continuous improvement of living standards, people have increasingly realized the basic meaning of "green". However, due to the drive of economic interests, the use of antibiotics has begun to flood, especially in large quantities in feed, which leads to the imbalance of normal flora in animals and inhibits the formation of the body's immune response, leading to serious superinfection and even death. Secondly, the residues of antibiotics in livestock and poultry and their meat, eggs, milk and other foods cannot be completely inactivated by heating. People who eat such foods for a long time may cause chronic poisoning. In addition, modern medical technology, pesticides, fertilizers, hormones, isotopes and other chemical p...

AI Technical Summary

Problems solved by technology

[0008] (2) The amount of sodium butyrate is not easy to control: as an organic acid, sodium butyrate has a small degree of dissociation and weak acidity. The amount of sodium butyrate to achieve the same acidification capacity is much larger than that of inorganic acids, and the cost of addition is high.

[0009] (3) Storage and transportation conditions are limited: Sodium butyrate products are stable at low temperature and in a sealed state under normal storage and handling conditions, but they cannot be mixed with substances of the opposite nature, dust, overheated items, and strong oxidants. It is easy to dilute and agglomerate or cause the feed to be damp

[0010] (4) High technical cost: The results of studying the absorption of SCFA (short-chain fatty acid) by nuclide tracer method show that the absorption and metabolism of SCFA in the colon of the body are very strong, and butyric acid is the fastest

[0011] (5) There is adverse stress: the oral mucosa of animals is soft and sensitive, and if low-priced, low-quality chemical grade sodium butyrate is used as an attractant, it would have thought of attracting food and maintaining the health of the animal body. However, it can often cause animal mucous membrane burns, resulting in decreased feed intake and even food refusal.

In addition, sodium butyrate may produce harmful decomposition products of carbon monoxide, carbon dioxide, sodium oxide, allergenic and toxic fumes and gases that may also cause central nervous system depression, eye and skin sensitization, and gastrointestinal and respiratory tract irritation

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