92 results about "Rose bengal" patented technology

New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

The invention discloses a special curing agent for curing stone and wood, belonging to the technical field of stone and wood curing. The present invention is composed of a variety of chemical raw materials, uses paraffin as a matrix, tocopheric acid as a strong antioxidant, walnut oil, silicone oil, propylene glycol, gum arabic powder, tiger red agar, fruit acid, eosin methylene blue agar It is made from the best combination of various raw materials and scientific compatibility. The special curing agent for curing stone and wood of the invention has a simple preparation process and is easy to be mass-produced. By using the invention, stone and wood can quickly produce a naturally formed pulping feeling, strengthen the protection and beauty of stone and wood, and meet people's needs for beauty and protection of stone and wood. The raw materials used in the present invention are non-toxic and harmless, and meet the requirements of relevant national standards.

The invention discloses high-cadmium-adsorption filamentous fungi penicillium chrysogenum J-5 as well as a preparation method and an application thereof. The preparation method comprises the following steps of: firstly weighing and putting 10g of cadmium polluted soil into 90mL of sterilized normal saline, vibrating on a constant-temperature shaking table, standing, taking supernatant liquid and diluting; secondly coating different dilution factors of diluent on a Martin rose-bengal flat plate containing 10mM of cadmium, and inversely placing the flat plate in a constant-temperature incubator for cultivation; thirdly, carrying out streaking and purification on microorganisms which grow on the flat plate, and then coating the organisms on the Martin rose-bengal flat plate containing cadmium again for cultivation; fourthly, after isolation and screening, storing a bacterial strain having stable resistance capacity on cadmium on a PDA (Potato Dextrose Agar) inclined plane. The obtained filamentous fungi penicillium chrysogenum J-5 has high tolerance and high adsorption property on multiple metals; the raw materials are easy to obtain and low in cost. The bacterial strain has relatively high fixation capacity on heavy metals in environments, can be used of reducing the biological toxic property of the heavy metals and is suitable for the in-situ remediation of large-area polluted soil.

New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.

A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.

The invention discloses an establishing method for a retinal edema animal model. A reasonable application of 577 nm laser combined with rose Bengal is used to block a retinal vein of a mouse to form retinal edema, and a non-invasive OCTA / OCT technique is used to continuously observe a retina of a model eye and edema states of the retina. The invention aims to invent the establishing method with small trauma to model animals, rapid onset effect, long maintenance time and simple and easy operation for the retinal edema animal model for meeting the corresponding experimental requirements well.