The invention discloses cooking wine for assisting to reduce blood glucose and a manufacturing method thereof. The cooking wine is prepared from the following raw materials in parts by weight: 400 to 500 parts of buckwheat powder, 80 to 120 parts of papaya powder, 80 to 100 parts of wheat germ powder, 35 to 40 parts of red dates, 10 to 15 parts of walnuts, 5 to 7 parts of oenanthe javanica leaves, 2 to 4 parts of immature bitter orange, 10 to 15 parts of tremella, 6 to 10 parts of fructus momordicae, 4 to 6 parts of liquorice root, 5 to 6 parts of fritillaria cirrhosa, 8 to 10 parts of semen sterculiae lychnophorae, 3 to 4 parts of acorn starch, 15 to 20 parts of grapefruit pulp, 8 to 10 parts of egg white powder, 5 to 6 parts of edible mushrooms, 2 to 4 parts of broccoli, 5 to 7 parts of asparagus, 25 to 45 parts of seasoning powder, 5 to 7 parts of spices, 10 to 15 parts of black sesame oil and 15 to 30 parts of salt. The cooking wine has the advantages of comprehensive nutrients, full and coordinated taste and high nutritive value, and the fritillaria cirrhosa and the semen sterculiae lychnophorae have the effects of clearing heat, improving eyesight and detoxifying, so that the effects of restoring body physiological functions, delaying senescence and prolonging life can be achieved with frequent drinking; additionally, health-care herbs of the oenanthe javanica leaves, the immature bitter orange, the liquorice root and the like which are added to the cooking wine have good effects of assisting to reduce blood glucose, the liver and the kidney can be nourished, qi can be tonified, blood can be produced, the blood glucose can be adjusted, and the cooking wine is an ideal health-care food for patients with hyperglycemia and diabetes.