Composition for preventing or treating learning ability or memory impairment containing water celery extract as an active ingredient and method for producing the same

A technology for memory impairment and learning disabilities, applied in medical preparations containing active ingredients, drug combinations, plant/algae/fungus/moss components, etc., can solve the problems of weak dementia prevention and treatment effects, and achieve prevention of induced dementia or The effect of memory loss

Active Publication Date: 2015-10-07
全罗南道生物产业振兴财团
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, as dementia progresses, not only acetylcholine neurons but also glutamatergic neurons occupying most of the neurons will degenerate, so the above-mentioned methods that focus on enhancing the activity of acetylcholine can only obtain a temporary weak effect. Dementia prevention and treatment effect
In addition, most drugs such as tacrine have serious side effects such as hepatotoxicity, vomiting, nausea, or diarrhea, so there is much controversy about their use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition for preventing or treating learning ability or memory impairment containing water celery extract as an active ingredient and method for producing the same
  • Composition for preventing or treating learning ability or memory impairment containing water celery extract as an active ingredient and method for producing the same
  • Composition for preventing or treating learning ability or memory impairment containing water celery extract as an active ingredient and method for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0053] Hereinafter, the present invention will be described in detail based on examples and experimental examples.

[0054] However, the following examples and experimental examples merely illustrate the present invention, and the scope of the present invention is not limited thereby.

experiment example 1

[0055] Experimental example 1: Comparison of acetylcholinesterase (AChE) inhibitory activity of various natural products (Ellman’s method)

[0056] The 70 (v / v)% ethanol aqueous extracts of cactus fruit, pomegranate, grapefruit, fig, Ashitaba (Angelica utilis makino), jujube and paddy celery were produced, and the inhibitory activity of acetylcholinesterase was compared.

[0057] Each ethanol aqueous solution extract was added with 600ml of alcohol (ethanol content 70(v / v)%) to 10g of dry sample, and extracted for 8 hours at 60°C without refluxing, filtered to remove the residue, at 50~60mmHg and 30~ Evaporation and concentration at 40°C, and hot-air drying of the thus-obtained concentrate to obtain ethanol extract powder.

[0058] After the above-mentioned ethanol extract powder is dissolved in dimethyl sulfoxide (DMSO), it is diluted in 100 mM phosphate (pH 8.0, referred to as "buffer I") at a concentration of 1000 μg / ml (dilution in DMSO is the final Concentration 10%). Mix the ...

experiment example 2

[0062] Experimental example 2: Comparison of the inhibitory activity of acetylcholinesterase (AChE) according to the water celery extraction method

[0063] Add 600ml of purified water to 10g of dried paddy field water celery, extract with hot water at 100°C for 8 hours, filter to remove the residue, evaporate and concentrate at 50-60mmHg and 30-40°C, and dry the resulting concentrated liquid with hot air The hot water extract powder is obtained.

[0064] In addition, add 600ml of alcohol (ethanol content 75(v / v)%) to 10g of dried paddy field water celery, and extract for 8 hours without refluxing at 60°C. After filtering to remove the residue, the temperature is 50-60mmHg and 30- It is concentrated by evaporation at 40°C, and the concentrated solution thus obtained is dried with hot air to obtain an alcohol extract powder.

[0065] Measure the inhibition rate of acetylcholinesterase activity of the above-mentioned paddy field water celery hot water extract powder and alcohol extrac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to a composition containing Oenanthe javanica extract as an active ingredient for preventing or treating learning disabilities or memory disorders, and to a method for preparing same. More particularly, the present invention relates to a composition which can be used as a pharmaceutical composition or functional health food and which is prepared by extracting an active ingredient from Oenanthe javanica, which is an edible herb, wherein the active ingredient provides the function of preventing acetylcholinesterase (AChE) from being activated, or the function of preventing or treating learning disability or memory disorder.

Description

Technical field [0001] The present invention relates to a composition for the prevention or treatment of learning ability or memory impairment containing water celery extract as an effective ingredient and a method for producing the same. More specifically, it relates to water celery used as a kind of edible spiced vegetables, especially from species Dry field water celery extracts effective ingredients that can inhibit the activity of acetylcholinesterase (AChE), prevent or treat learning ability or memory impairment, and use it as a pharmaceutical composition or health functional food. Background technique [0002] Water celery, also known as celery, water cress, and water celery, is a spiced vegetable that grows naturally in all parts of Korea, and is widely distributed from sub-frigid, temperate and tropical regions such as Sakhalin Island, mainland China, Japan, Southeast Asia, and Oceania. [0003] Water celery is divided into paddy field water celery and dry field water cele...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61P25/28A61P25/00
CPCA61K36/23A61P25/00A61P25/28
Inventor 徐维宪申技颖元范宁李惠珍李亨根郑卿熙金基明魏志向郑京玉成彗美申铉坰
Owner 全罗南道生物产业振兴财团
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap