75 results about "Micro raman" patented technology

The invention provides a laser spectrum analyzer combining a confocal micro-Raman spectrometer with a laser-induced breakdown spectrometer (LIBS). The analyzer comprises a micro-Raman system, a micro LIBS system, a high resolution micro-imaging system, a confocal micro-light path, and a spectrum receiving system with a time resolution function, and automatically switches into a white light micro-imaging observation mode, an automatic focusing mode, a LIBS spectrum working mode, and a Raman spectrum working mode. The significant characteristics of the invention are that compact combination of Raman with LIBS is realized by a micro confocal system; qualitative and quantitative analysis of substance elements at the same minimal position and molecular structure is realized; with the high-resolution imaging function, element spatial discrimination and substance structure chemical analysis can be carried out in micrometers so as to obtain complete information of spatial distribution images of chemical elements, substance structure and physical conditions of a sample.

The present invention provides for a method and an apparatus for characterizing wafer stress. At least one semiconductor device is processed. Metrology data from the processed semiconductor device is acquired. Micro-Raman data relating to the processed semiconductor device is acquired. A wafer-stress analysis based upon the metrology data and the micro-Raman data is performed. A feedback process based upon the wafer stress analysis is performed.

A fast and fully automated approach for determining the number of atomic planes in layered material samples is provided. Examples of such materials may include graphene and bismuth telluride (Bi2Te3), and materials from the bismuth selenide (Bi2Se3) samples is provided. The disclosed procedure allows for in situ identification of the borders of the regions with the same number of atomic planes. The procedure is based on an image processing algorithm that employs micro-Raman calibration, light background subtraction, correction for lighting non-uniformity, and color and grayscale image processing on each pixel of a graphene image. The developed procedure may further provide a pseudo-color map that marks the single-layer and few-layer regions of the sample. Beneficially, embodiments of the developed procedure may be employed using various substrates and can be applied to materials that are mechanically exfoliated, chemically derived, or deposited on an industrial scale.

A micro-Raman spectrometer system for use in differentiating tumor lesions from normal skin detects specific characteristics of Raman spectra indicative of cancer. A peak at 899 cm−1 and a higher intensity region in the 1325 cm−1 to 1330 cm−1 range indicate the presence of tumors. The spectrometer system may be applied for skin cancer detection and for mapping the margins of lesions. Cancer detection methods as described herein have achieved diagnostic sensitivity of 95.8% and specificity of 93.8%.

The invention discloses a micro-raman spectrum experiment apparatus for adjustable polarization direction continuous collaboration / covariation. A micro-raman spectrum system is composed of a laser machine, an Edge optical filter, a microscope and a Raman spectrograph, a polarization collaboration / covariation adjusting module is composed of a half-wave plate and a polaroid sheet. The laser emitted by the laser machine is performed Edge optical filter reflection, half-wave plate transmission and microscope focusing incidence on the surface of the measured object. The diffusion light collected by the microscope transmits through the half-wave plate, the Edge optical filter and the polaroid sheet and then enters in the Raman spectrograph for photorecording the spectrum information. By setting the vibration detection angle of the polaroid sheet as zero or nonzero value-alpha, the fast optical axis angle of the half-wave plate is adjusted to be half of the rotation angle in the polarization direction, so that collaboration regulation or alpha angle covariation regulation of polarization direction of incidence light and scattered light can be realized. On the basis of unchanged functions and precision of the traditional micro-raman spectrum experiment system, the modularization and simplification of controlling polarization collaboration / covariation can be realized, and the manufacture cost can be reduced.

The invention discloses an agricultural product pesticide residue detection method. The method comprises the following steps that template molecules, chitosan, hydroxyethyl acrylate, polyethyleneimineand deionized water are taken, imprinted hydrogel with the template molecules is synthesized; pretreatment of to-be-detected vegetables is completed, and a to-be-detected sample solution is prepared;the template molecules of the obtained imprinted hydrogel are removed; a standard Raman spectrogram of the template molecules is made; the imprinted hydrogel obtained after the template molecules areremoved is soaked in the to-be-detected sample solution and fished out, after confocal micro-Raman Spectrum detection is conducted, the obtained Raman Spectrum is compared with the standard Raman spectrogram, and then whether the template molecules are contained in samples or not is judged, and the content range of the molecules is judged preliminarily. Accordingly, the hydrogel with the specificrecognition function is prepared through a molecular imprinting technology, after the to-be-tested samples are adsorbed and enriched by the hydrogel, spectra collection is conducted by means of a portable Raman spectroscope, and whether the samples contain pesticide or not is judged by comparing with the standard Raman spectrogram.

The invention discloses a Raman enhancement detection method and a Raman enhancement detection device for a micro LED chip. According to the detection method provided by the invention, photoluminescence detection and Raman detection are combined, the photoluminescence detection provides luminescence wavelength and brightness information, and the Raman detection provides electrical properties, so that the problem of insufficient photoluminescence detection accuracy is solved; electron energy level resonance and surface plasmon resonance enhanced Raman technologies are adopted, so that the Ramanscattering intensity is enhanced by 103 to 108, part of the Raman scattering intensity reaches the photoluminescence intensity, and a foundation is laid for rapid measurement; the metal nanostructurenot only improves the luminous efficiency of the micro LED chip, but also can enhance Raman scattering signals by using surface plasmon, so that the detection speed is increased; microscopic Raman detection is a nondestructive testing means, the detection process is simple, the required time is short, the detection speed is high, the micro LED chip does not need to be specially treated, and the method is suitable for massive detection of the micro LED chip.

The invention discloses a method for detecting electrical aging of a silicone rubber composite insulator. The method for detecting the electrical aging of the silicone rubber composite insulator includes a first step of taking a high-voltage-side shed of the silicone rubber composite insulator of a running line as a sample, and a second step of collecting micro-Raman spectra on the surface of the sample, and judging the degree of the electrical aging of the sample according to the fact that whether an obvious Raman peak exists at the position of 2906cm-1, 2966cm-1, 3371cm-1, 3437cm-1, 3524cm-1. The method for detecting the electrical aging of the silicone rubber composite insulator has the advantages of being less in sample, short in detection time and easy and convenient to conduct. Detection can be finished without the need of complicated treatment of the sample. The Raman peak is used as a tool of analysis of the electrical aging of the silicone rubber composite insulator, so that subjective factors such as a man-made factor and an environment factor are eliminated and the accuracy is improved.

The invention discloses a graphene sheet intercalation compound preparation method and an in situ micro-Raman representation system. The preparation method comprises the following steps: respectively placing the graphene sheet and ferric trichloride into a glass tube and a cuvette which are connected ang communicated with each other; vacuumizing the glass tube and the cuvette by a molecular pump; sealing the vacuumized glass tube and cuvette by an alcohol lamp; heating to 340 DEG C and keeping the temperature for 6 to 24 hours; and cooling to the normal temperature. The in situ micro-Raman representation system comprises the glass tube and the cuvette which contain the graphene sheet and the ferric trichloride and sealed from the outside and communicated with each other, a laser, a Raman spectrometer, a heating platform, a lifting platform, a translational platform and two scanners. The graphene sheet / ferric trichloride intercalation compound preparation method is simple and practical; and the in situ micro-Raman representation system can be used for in situ representing the micro-Raman spectrum of a graphene / ferric trichloride intercalation compound, and in situ monitoring the formation condition of the graphene / ferric trichloride intercalation compound.

The invention relates to a method for evaluating the water environment disturbance based on characteristic Raman scattering of alga cells, belonging to the technical field of water environment evaluation. The method comprises the following steps: (S1) culturing alga cells under different simulated water environment disturbance factors; (S2) carrying out sampling representation on alga liquid in aculturing period, carrying out Raman imaging on the alga cells by virtue of a confocal microscope Raman spectrometer, and carrying out pretreatment on a Raman spectrum of the alga cells; (S3) analyzing characteristic Raman spectrums of the alga cells under different culturing conditions, so as to obtain the Raman difference of characteristic fingerprints of the alga cells, and determining the category of the alga cells; (S4) establishing a water environment disturbance evaluation model based on the characteristic Raman scattering of the alga cells; and (S5) evaluating and predicting a water environment according to the water environment disturbance evaluation model established in the steps (S4). According to the method, the characteristic Raman spectrum of the alga cells is established andis utilized for predicting the disturbances of different environments, so that the rapid evaluation of the water environment disturbance is realized.

A process for preparing smoothened III-N, in particular smoothened III-N substrate or III-N template, wherein III denotes at least one element of group III of the Periodic System, selected from Al, Ga and In, utilizes a smoothening agent comprising cubic boron nitride abrasive particles. The process provides large-sized III-N substrates or III-N templates having diameters of at least 40 mm, at a homogeneity of very low surface roughness over the whole substrate or wafer surface. In a mapping of the wafer surface with a white light interferometer, the standard deviation of the rms-values is 5% or lower, with a very good crystal quality at the surface or in surface-near regions, measurable, e.g., by means of rocking curve mappings and / or micro-Raman mappings.

The invention discloses a technology and a device which is applied to the Micro-Raman spectrum system for simple and coordinated regulation of polarization direction of incidence light and scattered light. A laser device, an incidence and emergent light interface, a microscope and a Raman Spectrometer constitute a Micro-Raman spectrum system while a half-wave plate and a polaroid constitute a polarization regulation assembly. Laser emitted from the laser device sequentially pass through the incidence and emergent light interface, the half-wave plate and the polaroid before passing through the microscope and reaching the surface of an object to be detected.Back scattered light collected by the microscope sequentially passes through the polaroid and the half-wave plate before passing through the incidence and emergent light interface and entering the Raman Spectrometer to form spectral information. In the invention, the fast optical axis angle of the half-wave plate and polarization detection angle of the polaroid are respectively adjusted to be half of the rotation angle in the polarization direction and to be equal to the rotation angle in the polarization direction, so that coordinate regulation of polarization direction of incidence light and scattered light can be realized. In the invention, modularization of polarization control is realized, so that acquisition of the maximum grating diffraction efficiency of the scattered light entering the spectrometer can be ensured and the optimal light spectrum contrast ratio can be obtained.

The invention discloses an MEMS micro Raman spectrometer, which includes a sampling module, a control display module, and an MEMS dispersion module. All the modules of the MEMS micro Raman spectrometer have higher integration degree, the equipment volume can be reduced more easily, and a handheld spectrometer can be made. Also the MEMS micro Raman spectrometer can strictly inhibit the stray light genegrated by a laser lighting system and a lens common optical path of Raman scattering light. The MEMS micro Raman spectrometer provided by the invention adopts an embedded operating system to complete data processing function, can realize handheld use, and can completely break away from computers to work independently. The MEMS micro Raman spectrometer provided by the invention adopts MEMS technology grating and movable F-P cavity integrated dispersion, can guarantee a wide free spectral range, at the same time can acquire narrow full width at half-maximum, and can acquire high spectral resolution.

The invention relates to a method for detecting component information of a throat swab sample by adopting surface enhanced micro-Raman spectroscopy. The method comprises preparation of a surface enhancement reagent, treatment of the throat swab sample, measurement of a surface enhanced Raman spectrum of the sample and processing and analysis of Raman spectrum data. According to the technical scheme, the method comprises the following steps: preparing the enhancement reagent for enhancing the Raman spectrum of the sample; smearing the throat swab sample on a smooth and clean pure aluminum sheet, dripping the surface enhancement reagent, and naturally air-drying the pure aluminum sheet at room temperature to prepare a throat swab-surface enhanced Raman test sheet; performing micro-Raman spectroscopic test on the throat swab-surface enhanced Raman test sheet to acquire the surface enhanced micro-Raman spectrum of the throat swab sample, and analyzing biochemical component information and features of the throat swab sample by virtue of spectral features. The method has the advantages of short detection time, low cost, convenience and rapidness in process and the like, and rich biochemical component information of the throat swab sample can be obtained, so that a rapid and effective analysis method can be provided for biochemical features and changes of intracavity mucous tissues.

The invention provides an automatic detection system of circulating tumor cells based on a Raman spectrum. The system is composed of a blood sample processing module, a circulating tumor cell detection module, a data processing module and a result output module, wherein the blood sample processing module is mainly based on an enriching effect on circulating tumor cells of a microporous filter chip, the circulating tumor cell detection includes optical microimaging detection and micro-Raman spectrum detection, and detection data are compared with a database, so that information such as the quantity, kind, period and the like of the circulating tumor cells (CTC) are obtained ultimately.The system has the advantages of high integration level, simplicity in operation and good specificity of the Raman spectrum, a detection result can be obtained when a blood sample is directly put in the system, and the system can be widely applied to the fields of clinical blood test, early diagnosis and prognosis monitoring of cancer, basic scientific research and the like.

The invention relates to a micrometering system for measuring electro-spin fluorescence, which is characterized by comprising a micro Raman spectrometer, a broad-band line polaroid sheet, a broad-band one-fourth wave plate, a magnet system, a digital voltage source meter and an over-long operating distance microobjective. The micro Raman spectrometer, the broad-band line polaroid sheet and the broad-band one-fourth wave plate are spaced by preset distances and positioned in a same light path; the digital voltage source meter is connected in parallel with the magnet system; and the over-long operating distance microobjective is positioned between the broad-band one-fourth wave plate and the magnet system and is in the same light path with the broad-band one-fourth wave plate and the magnet system.

The invention discloses a short-term weathered spilled oil tracing method based on a confocal micro Raman spectrum. The method comprises the following steps: measuring Raman fingerprint data of crude oil and spilled oil samples adopting a 532nm, 514nm or 488nm of laser device as an excitation light source; converting the obtained fingerprint data into multi-dimensional space vectors; and carrying out cluster analysis by taking vector cosine and Pearson pertinence as criteria to obtain a trace analysis result of the spilled oil, so as to determine the origin information. By adopting the short-term weathered spilled oil tracing method, uncertain factors and errors caused by the traditional Raman data processing software by a polynomial fitting deduction baseline are avoided; the accuracy and the creditability of the trace result of the short-term weathered spilled oil can be obviously improved; an important basis is provided for responsibility identification and economic compensation of an oil spilling event; a theoretical foundation also can be provided for exploration of a mechanism of transportation and conversion of the spilled oil in the pollution treatment and environmental modification processes.

Provided is a flake-like carbon material that is suitable for use as an electrode material for an aqueous-electrolyte secondary battery. When the end surface of a particle of the carbon material is measured by using a micro-Raman spectrometer, the peak area (ID) of the peak measured in the 1300-1400 cm-1 range of the Raman spectrum, and the peak area (IG) of the peak measured in the 1580-1620 cm-1 range of the Raman spectrum have a IG / ID intensity ratio (G value) that is 5.2-100 inclusive. The average plane spacing (d002) of the (002) planes, as measured by X-ray diffractometry, is equal to or less than 0.337nm. The material has an optical structure of a specific shape. Also provided are a method for manufacturing the carbon material, a carbonaceous material for a battery electrode that includes the carbon material, a paste for an electrode, and a secondary battery that exhibits superior charge / discharge cycle properties and heavy-current carrying properties.

The invention discloses a multi-focal Raman spectrum acquisition instrument based on adiffractive optical element, and effectively solves the technical problem that higher incident intensity affects Raman signal acquisition, so that the acquisition efficiency of Raman spectrum can be further improved, and micro Raman measurement is realized. The diffractive optical element is introduced into a Raman spectrometer, so that light spot energy focused on a sample to be tested can be dispersed, the damage of focused high-strength light spots to the sample to be tested is reduced, and an application field of the Raman spectrum can be expanded; meanwhile, the number of focal spots can be effectively increased, so that the collecting efficiency of the Raman spectrum is improved, and high-speed micro Raman is realized. The multi-focal Raman spectrum acquisition instrument provided by the invention has a wide prospect on researching a laser intensity sensitivity system.

The invention discloses a method for measuring residual stress of a metal microstructure, belongs to the technical field of micro manufacturing, and relates to a method for measuring residual stress of a metal microstructure. Solid particles with Raman activity are preprocessed and are mixed with an electroforming liquid to form a suspending liquid for micro electroforming. By taking the solid particles as stress tracking signals, the residual stress of the metal micro structure is measured through micro Raman spectrometry. The metal micro structure is prepared through adding the solid particles with the Raman activity to perform codeposition with metal, the problem of the restriction of incapability of measuring the residual stress of the metal micro structure by use of an X ray diffraction method is solved, the scope of application of the micro Raman spectrometry in measurement of the residual stress is expanded, the method has the advantages of wide application scope, simplicity and high efficiency, and the dimension precision and the manufacturing yield of a metal micro device are improved.

A gallium nitride substrate has a surface with a diameter of not less than 100 mm, a difference being not less than 0.1 cm−1 and not more than 2 cm−1 between maximum and minimum values of wave numbers at a maximum peak of peaks corresponding to an E2H phonon mode in micro-Raman scattering mapping measurement at each of square regions having sides each having a length of 2 mm, the square regions being located at a total of five locations including a central location and four circumferential edge locations on the surface of the gallium nitride substrate, a difference being not more than 2 cm−1 between maximum and minimum values of the wave numbers at the maximum peak of the peaks corresponding to the E2H phonon mode at all of measurement points in the five locations.

The present invention provides an angular resolution micro-Raman spectral detection device and detection method, and relates to the technical field of optical measuring devices. The angular resolutionmicro-Raman spectral detection device comprises: a Raman detection mechanism and an inclined angle control mechanism. The Raman detection mechanism is provided with a signal port. The signal port corresponds to a sample. The Raman detection mechanism can emit a laser signal to a sample surface, collect scattered signals excited by the sample surface, and perform Raman spectral analysis. The Ramandetection mechanism is connected with the inclined angle control mechanism. The inclined angle control mechanism is used for adjusting a connecting angle of the Raman detection mechanism and the inclined angle control mechanism, so as to adjust an angle of a detection inclined angle of the angular resolution micro-Raman spectral detection device. The scattered signals at different detection inclined angles on the same detection point on the sample surface are collected to obtain spectral data at different detection inclined angles on the same detection point, so as to realize the fine measurement of the sample.

The invention discloses a detecting method of antibiotics in a water body. The method includes the following steps of dissolving a template molecule in distilled water, adding mesoporous silica and graphene oxide to be evenly mixed to obtain a water phase, dissolving a functional monomer, a crosslinking agent and an initiator in a methylbenzene solvent to be evenly mixed to obtain an oil phase, ultrasonically mixing the water phase and the oil phase, putting the mixture into an oven for polymerization reaction to obtain a print polymer, completing the washing and drying treatment of the printpolymer, taking a water sample filtering membrane for removing impurities, adjusting the pH of a water sample passing through the membrane, adding a chelating agent to be mixed, soaking the print polymer without the template molecule in to-be-detected sample liquid for 3-5 minutes, scooping up the print polymer for confocal micro-Raman spectrum detection to obtain a Raman spectrogram, and comparing the obtained Raman spectrogram with a standard Raman spectrogram to judge whether the water sample contains sulfanilamide antibiotics or not and primarily judge the content range of the sulfanilamide antibiotics. The antibiotics in the water body can be rapidly detected at a low cost.

A process for preparing smoothened III-N, in particular smoothened III-N substrate or III-N template, wherein III denotes at least one element of group III of the Periodic System, selected from Al, Ga and In, utilizes a smoothening agent comprising cubic boron nitride abrasive particles. The process provides large-sized III-N substrates or III-N templates having diameters of at least 40 mm, at a homogeneity of very low surface roughness over the whole substrate or wafer surface. In a mapping of the wafer surface with a white light interferometer, the standard deviation of the rms-values is 5% or lower, with a very good crystal quality at the surface or in surface-near regions, measurable, e.g., by means of rocking curve mappings and / or micro-Raman mappings.

A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.

The invention belongs to the technical field of Roman spectrum analysis and develops a microscope heat state device used for measuring gas solubility in a high-temperature molten salt system on the basis of the Roman spectroscopy. The microscope heat stage device comprises a heat stage furnace and a heat stage reactor; the heat stage furnace comprises a heat stage furnace shell, more than two silicon carbide rods, stainless steel clamps and power lines; the heat stage reactor comprises a heat stage reaction base, a heat stage reactor flange cover, a heat stage screw piston, a sample pool and a quartz observation tablet. A sealed quartz window is arranged in the upper portion of the sample pool, volatile of high-temperature molten salt is prevented from polluting the surface of a lens, and Roman incident laser is ensured to pass through the quartz observation window; the heat stage reaction is cooled through water path circulation of the heat stage reaction flange cover, and temperature nearby the microscope heat stage is ensured not to be so high; the microscope lens is close to the surface of the sample pool, which is suitable for detection of the micro-Raman spectrum; the silicon carbide rods are long and far from cold ends of the silicon carbide rods, even heating of a crucible is guaranteed, and temperature gradient in the sample pool is decreased.

A gallium nitride substrate has a surface with a diameter of not less than 100 mm, a difference being not less than 0.1 cm−1 and not more than 2 cm−1 between maximum and minimum values of wave numbers at a maximum peak of peaks corresponding to an E2H phonon mode in micro-Raman scattering mapping measurement at each of square regions having sides each having a length of 2 mm, the square regions being located at a total of five locations including a central location and four circumferential edge locations on the surface of the gallium nitride substrate, a difference being not more than 2 cm−1 between maximum and minimum values of the wave numbers at the maximum peak of the peaks corresponding to the E2H phonon mode at all of measurement points in the five locations.

The invention discloses a high-throughput detecting system for obtaining trace mass and molecular structure information. A micro cantilever array fixed on a piezoelectric ceramic actuator is driven bya voice coil motor to translate along a width direction of a micro cantilever beam, so that laser beams are projected one by one onto the micro cantilever array, the laser reflected by a tip is detected by a photoelectric position sensitive detector to obtain a bending signal of a free end of each micro cantilever beam, and the vibration frequency of the micro cantilever beam is adjusted by the piezoelectric ceramic actuator; a micro Raman spectrum unit is disposed and is composed of an observation optical path sub-unit and a Raman laser optical path sub-unit, which work in a time division manner; the microstructure of a sample on the surface of the free end of the micro cantilever beam is obtained by using the observation optical path sub-unit; and a Raman spectrum is obtained by using the Raman laser optical path sub-unit, and then the molecular structure information of the sample is obtained. The high-throughput detecting system disclosed by the invention combines the micro cantilever beam sensing and micro Raman technology to realize the detection of trace mass changes, and is used for observing the appearance of the sample, and detecting the change of a molecular structure ina reaction process in real time.

A multi-functional microscope beam introduction device comprises an upper clamping groove plate, a shell, a reflecting mirror and a dovetail groove, beam introduction is achieved by a 45-degree adjustment mirror bracket and the reflecting mirror, the multi-functional microscope beam introduction device is characterized in that the 45-degree adjustment mirror bracket is provided with two pairs of high-accuracy threads, bidirectional angle accuracy adjustment can be performed, so that the beam angle is adjusted, the deviation of an incident angle is eliminated, and the device accuracy is improved; and moreover, a plurality of mirror bracket shells, the 45-degree adjustment mirror bracket and the universal reflecting mirror can be arranged on a sliding plate, sliding is performed by a slidingblock guide rail, the selection of a conventional function is achieved by moving of the sliding plate during the application process, so that the device has wider applicability.

The invention belongs to the field of cosmetic authenticity identification, and particularly relates to a Raman spectrum-based cosmetic authenticity nondestructive identification method which comprises the following steps of S1, establishing a microscopic Raman discrimination model library and a handheld Raman discrimination database, S2, collecting an atlas of a to-be-identified sample by utilizing handheld Raman, comparing the collected atlas with the handheld Raman discrimination database, preliminarily judging the to-be-identified sample, and entering the next step if the authenticity of the to-be-identified sample cannot be judged, and S3, collecting the atlas of the to-be-identified sample by using microscopic Raman, comparing the collected atlas with the microscopic Raman discrimination model library, and making a final determination. Microscopic Raman spectroscopy is combined with a handheld Raman spectroscopy technology, ink identification is performed on inner and outer packages of cosmetics, contents are subjected to scanning detection, joint library establishment and comparison and mutual complementation to verify genuine products, and the method is simple to operate, very high in universality, capable of effectively resisting interference of moisture in the cosmetics, high in identifiability and high in accuracy.