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79 results about "L-Epicatechin" patented technology
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Myceliated cacao products and methods for making myceliated products from green cacao and other agricultural substrates
ActiveUS20150257406A1Lower Level RequirementsImprove the level ofCocoaCoffeeGallic acid esterAdditive ingredient
The present invention provides a method for the preparation of a myceliated cacao bean or other agricultural product. This method includes providing cacao beans or other agricultural substrate, optionally hydrating the cacao beans or other agricultural product, and optionally pasteurizing or sterilizing the cacao beans or other agricultural substrate to provide prepared cacao beans or other agricultural substrate, and a step of inoculating the prepared cacao beans or other agricultural substrate with a prepared fungal component and culturing the inoculated cacao beans or other agricultural substrate to prepare the myceliated product. The methods of the instant invention result in prepared cacao beans or other agricultural substrate having reduced levels of undesirable taste components, such as theobromine, catechin, epicatechin, gallic acid equivalents, and / or 2-methoxy-3-isopropylpyrazine, and increased levels of myceliation products, such as fungal β-glucans, chitin, proteins, glycoproteins, pyrazines and polysaccharides, relative to starting cacao beans or other agricultural substrate.
Owner:MYCOTECH
Packaged, tea-based beverages
ActiveUS20050095343A1Process stabilityAdd flavorFruit and vegetables preservationTea extractionHigh concentrationSalty taste
Provided are packaged, tea-based beverages, which stably contain catechins at high concentration, are free of any salty taste, and have the inherent flavor and taste of tea. They contain the following ingredients (A) and (B): (A) from 320 mg / 500 mL to 1,300 mg / 500 mL of non-polymer catechins, and (B) water, wherein: (C) the content of non-epicatechins in the non-polymer catechins is from 40 to 80 wt. %, (D) the content of gallates in the non-polymer catechins is from 35 to 100 wt. %, (E) the weight ratio of the non-polymer catechins to sodium ions is from 12 to 16, and (F) the pH is from 5 to 7.
Owner:KAO CORP
Method used for separating and identifying flavonoid matters in tobacco by adopting liquid chromatography-mass spectrography
Owner:YUNNAN ACAD OF TOBACCO AGRI SCI
Process for the preparation of theaflavin-enhanced tea products
Provided is a process for preparing a theaflavin-enhanced tea product including a step of subjecting a tea-source to enzymatic fermentation in the presence of added exogenous epicatechin.
Owner:CONOPCO INC D B A UNILEVER
Quality control method of lichee polyphenols and products thereof
InactiveCN105223300AEnsure consistencyGuaranteed stabilityComponent separationProcyanidin B2Quantitative determination
The invention discloses a quality control method of lichee polyphenols and products thereof, and aims to provide the lichee polyphenols with extensive use and a method capable of simultaneously qualitative and quantitative determination of the content of various effective components in the litchi polyphenols and preparations thereof and building of comprehensive evaluation and monitoring of the quality. The method comprises the steps: with lichee peel, kernels and epicormic branches with leaves as raw materials, extracting to obtain polyphenols, further carrying out column chromatography and extraction, combining with HPLC semipreparative chromatography, and separating to obtain a compound 1 (-)-epicatechin, a compound 2 procyanidin A2, a compound 3 procyanidin B2, a compound 4 epicatechin-(4beta->8,2beta->O->7)-epicatechin-(4beta->8)-epicatechin called PC-C for short, a compound 5 B-type procyanidin dimer, and a compound 6 A-type procyanidin trimer. The quality control method belongs to the technical field of chemical detection.
Owner:GUANGDONG PHARMA UNIV
Myceliated products and methods for making myceliated products from cacao and other agricultural substrates
ActiveUS10231469B2Enhanced ability to grow on and metabolize and utilizeMore componentsCocoaGallic acid esterAdditive ingredient
Owner:MYCOTECH
Rhizome nelumbinis polyphenol extractive and preparation method and application thereof
ActiveCN107501228AHigh yieldSignificant browning effectFood ingredient as antioxidantFruit and vegetables preservationPectinaseChlorogenic acid
The invention discloses a rhizome nelumbinis polyphenol extractive and a preparation method and application thereof. The rhizome nelumbinis polyphenol extractive comprises epicatechin, catechinic acid, rutin, chlorogenic acid, caffeic acid, propylgallate and procyanidine oligomer. The preparation method comprises the following steps: carrying out aqueous enzymatic method extraction on rhizome nelumbinis by compound enzyme of cellulase and pectinase to obtain a primary extractive; carrying out membrane separation on the primary extractive to obtain the rhizome nelumbinis polyphenol extractive. Rhizome nelumbinis polyphenol adopted by the rhizome nelumbinis polyphenol extractive belongs to a diet source and is taken as the substrate of polyphenol oxidase, enzymatic reaction can be regulated and controlled, an effect on inhibiting the browning of fruits and vegetables is obvious, and the rhizome nelumbinis polyphenol extractive is a good natural fruit and vegetable preservative and antioxidant. A process for preparing the rhizome nelumbinis polyphenol is characterized in that biological enzyme extraction and membrane separation purification technologies are combined, a preparation yield is relatively high, the obtained extractive is natural and is free from toxic or side effect, the whole preparation process is environmentally-friendly and low in carbon, and the rhizome nelumbinis polyphenol extractive can be widely applied to food processing.
Owner:WUHAN POLYTECHNIC UNIVERSITY
Preservation solution for umbilical mesenchymal stem cells
ActiveCN110800732AImprove stabilityReduce riskCell dissociation methodsDead animal preservationSodium heparinUmbilical cord
The invention provides a preservation solution for umbilical mesenchymal stem cells and a preparation method for the preservation solution and belongs to the technical field of stem cell preservation.The cell preservation solution provided by the invention comprises 85%-93% (v / v) of fetal calf serum, 5%-12% (v / v) of dimethyl sulfoxide, 0.4%-0.8% (v / v) of low-molecular-weight calcium heparin injection, 1%-1.2% (v / v) of low-molecular-weight sodium heparin injection, 0.2%-0.4% (w / v) of anthocyan and 0.4%-0.6% (w / v) of epicatechin. The umbilical mesenchymal stem cells are subjected to separation,culture and subculture and then are preserved in the preservation solution, so that the activity and survival rate of the stem cells can be maintained, meanwhile, the stability of preservation can beimproved, the preservation time can be prolonged, and the risk can be lowered.
Owner:HUNAN YUANPIN CELL TECH CO LTD
Catechu extract composition for resisting tubercle bacillus, preparation method of catechu extract composition, pharmaceutical preparation containing catechu extract composition, and application of catechu extract composition
InactiveCN102526170AHigh effective contentGood treatment effectAntibacterial agentsOrganic active ingredientsTherapeutic effectStructural formula
The invention discloses a catechu extract composition for resisting tubercle bacillus, a preparation method of the catechu extract composition, a pharmaceutical preparation containing the catechu extract composition, and application of the catechu extract composition. The catechu extract composition contains a flavanoid compound of which the purity is more than 50%, and the flavanoid compound takes catechin and / or epicatechin as main components. The main structural formulas (I) and (II) of the flavanoid compound are shown in the specifications, wherein R1, R2, R3, R4 and R5 are respectively and independently selected from hydrogen, C1-C6 alkyl, beta-D-glucopyranesyl, SO3 or PO3. By adopting a chromatographic process for refining and purifying the catechu extract composition disclosed by the invention, the effective content is as high as 99.5%. The catechu extract composition and the pharmaceutical composition thereof have excellent effects on improving or treating pulmonary tuberculosis, treating ulcerative bone tuberculosis and AIDS (Acquired Immune Deficiency Syndrome) complicated by tuberculosis, treating drug resistant tuberculosis, and especially treating drug resistant tuberculosis and AIDS complicated by tuberculosis.
Owner:许学志
Preparation method of epicatechin monomer
InactiveCN105219815AAchieve preparationSolve technical problems that are difficult to separateOrganic chemistryFermentationTea catechinGreen teas
The invention relates to a preparation method of an epicatechin monomer. The preparation method comprises the following steps of: (1) adding tannase to a solution containing large-leaf green tea catechin extract, carrying out static enzymolysis at 30-35 DEG C, intermittently stirring, and centrifugally filtering to obtain an enzymolysis solution; (2) introducing the enzymolysis solution into a chromatographic column loaded with adsorptive resin, carrying out gradient elution with ethanol elution agent, collecting eluate, concentrating eluate to 16-18 Baume degree to obtain concentrate, standing the concentrate at 0-4 DEG C for 48-72h, adding a little of epicatechin monomer, crystallizing and recrystallizing, centrifuging and drying to obtain the epicatechinmonomer. According to the method, epicatechin gallate is subjected to enzymolysis by using tannase, so that the method has good transformation effect, high transformation rate and high product quality, short preparation period, and low cost, and is suitable for scaled production.
Owner:HUBEI ZHONGXIN BIOTECH CO LTD
Synergistically-effective antioxidant composition for pets
InactiveUS20180303127A1Function increaseIncrease alertnessAntinoxious agentsAnimal feeding stuffVitis viniferaAntioxidant
The invention concerns a pet food or a pet supplement comprising a synergistically-effective antioxidant composition comprising an extract of Vitis vinifera and an extract of Vaccinium angustifolium, wherein said composition comprises at least 1% of catechins and / or epicatechins and at least 5 ppm of ferulic acid. The present invention further relates to the use of a synergistically-effective antioxidant composition as a medicament for pets, in particular in a method for treating a neurodegenerative disorder in a pet.
Owner:SPECIALITES PET FOOD +1
Synthesis of oligomeric epicatechin and catechin-derived procyanidins
Various processes are disclosed for preparing procyanidin oligomers having (4,8)-interflavan linkages. In an improved process, a tetra-O-protected-epicatechin or catechin monomer or oligomer is coupled with a protected, C-4 alkoxy-activated-epicatechin or -catechin monomer in the presence of an acidic clay instead of a Lewis acid. In a second process, a 5,7,3′,4′-tetra-O-protected or preferably penta-O-protected-epicatechin or -catechin monomer or oligomer is reacted with a tetra-O-protected or preferably penta-O-protected-epicatechin or -catechin monomer having a thio activating group at the C-4 position; the coupling is carried out in the presence of silver tetrafluoroborate. In third process, two molecules of a penta-O-protected-epicatechin or -catechin monomer activated with a 2-(benzothiazolyl)thio group at the C-4 position are self-condensed in the presence of silver tetrafluoroborate. An improved two-step process for preparing a C-4 alkoxy activated tetra-O-benzyl-protected, 8-bromo-blocked-epicatechin or -catechin monomer is also provided. The use of naturally-derived and synthetically-prepared procyanidin (4β,8)4-pentamers to treat cancer is also disclosed.
Owner:MARS INC
Use of catechin and epicatechin compounds for up-regulation of expression level of microRNA-126
The invention belongs to the field of medicines or health products, and particularly relates to the use of catechin and epicatechin compounds in the preparation of drugs for up-regulating the expression level of microRNA-126. As found by researches, catechin, catechin gallate, gallocatechin, (-)-gallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallatecan up-regulate the expression level of the microRNA-126, and can be used for treating tumors, asthma, inflammatory bowel disease, vascular inflammation, hypertension, type 2 diabetes mellitus, diabetic nephropathy or diabetic retinopathy.
Owner:CATCH BIO SCI & TECH
Synthesis of 4alpha-arylepicatechins
InactiveUS20050014958A1Easy to separateConveniently generatedGroup 4/14 element organic compoundsBulk chemical productionArylAlcohol
Oligomeric procyanidins containing 4α-linked epicatechin units are rare in nature and have hitherto not been accessible through stereoselective synthesis. Provided herein is the preparation of the prototypical dimer, epicatechin-4α,8-epicatechin, by reaction of the protected 4-ketones with aryllithium reagents derived by halogen / metal exchange from the aryl bromides. Removal of the 4-hydroxyl group from the resulting tertiary benzylic alcohols is effected by tri-n-butyltin hydride and trifluoroacetic acid in a completely stereoselective manner, resulting in hydride delivery exclusively from the β face.
Owner:MARS INC
Insulating material for cable sealing and preparation method thereof
InactiveCN113046017AHigh bonding strengthHigh tensile strengthNon-macromolecular adhesive additivesPolyureas/polyurethane adhesivesPhosphoric Acid EstersAdhesive
The invention discloses an insulating material for cable sealing and a preparation method thereof, and relates to the technical field of adhesives. The preparation method of the insulation sealing material comprises the following steps: S1, mixing castor oil polyoxyethylene ether and polypropylene oxide glycol in parts by weight to obtain a product M; s2, uniformly mixing and stirring the product M and a component B to obtain a mixture N; S3, weighing micron-sized barium sulfate, oleylamine polyoxyethylene ether, nano-sized silicon dioxide, fibrous calcium carbonate whiskers, isophenylpropyl phenyl phosphate, antimony trioxide, triaryl phosphate, a silane coupling agent and epicatechin in parts by weight, and conducting mixing to obtain a mixture Q; and S4, uniformly mixing and stirring the mixture N and the mixture Q to obtain the insulating sealing material. The insulating material prepared by the preparation method disclosed by the invention has excellent insulating property, can keep good heat-conducting property, and is high in curing speed, outstanding in bonding strength, good in sealing property and excellent in flame-retardant effect; and the anti-aging capability is enhanced, and the service life is long.
Owner:ZHEJIANG DISIWEI ELECTRIC
High-stability pigment derivative and preparation method thereof
ActiveCN111034902ASolve the problem of poor color stabilitySteady redFood ingredient as colourFood dryingBleachPerylene derivatives
The invention discloses a high-stability pigment derivative, and the number-average molecular weight of the pigment derivative is 523-168Da. In the structural unit, the content of epicatechin is 5-30%, the content of catechin is 3-75%, the content of gallocatechin is 1-13%, the content of epigallocatechin is 1-5%, the content of catechin gallate is 1-16%, and the content of epicatechin gallate is2-17%. The pigment derivative provided by the invention belongs to a natural anthocyanin derivative, is not influenced by the chemical balance of salt, chalcone, Quinoid alkali and methanol pseudo-base, can keep stable red in an acidic to neutral (pH 1.0-7.0) solution, and is not influenced by pH, oxygen, a reduced bleaching agent and temperature. The problem of poor color stability of natural anthocyanin is solved.
Owner:SHANTOU UNIV
Novel compounds with radioprotective effects and preparation method and pharmaceutical use thereof
ActiveCN107021961AProlong lifeHigh activityOrganic active ingredientsOrganic chemistryApigeninAstaxanthin
The present invention provides novel compounds with radioprotective effects and pharmaceutically acceptable salts, prodrugs, and solvates thereof as shown in formula (I). Ar is selected from astaxanthin, anthocyanins, proanthocyanidins, resveratrol, VitaminA, VitaminC, VitaminE and flavonoids such as apigenin, luteolin, kaempferide, quercetin, glycyrrhizin, hesperidin, dihydroquercetin, Dihydromorin, (+) catechin, (-) epicatechin, ginkgetin, Ophiopogonone A, rubrofusarin, baicalein and the like, R1 is selected from the following groups shown in the specification, further, the present invention provides a preparation method and use of the compounds and the derivatives thereof in treatment of radiation injuries.
Owner:SHANGHAI KECHOW PHARMA
Utility of (+) epicatechin and their analogs
Owner:SPHAERA PHARMA PTE LTD +1
Preparation method and application of hydroxyl cinnamyl ester type catechin
ActiveCN111233810ASimple methodMild conditionsOrganic active ingredientsMetabolism disorderCoumaric acidCaffeic acid
The invention relates to a preparation method and application of hydroxyl cinnamyl ester type catechins. The hydroxyl cinnamyl ester type catechins comprise four catechins which are respectively namedas epicatechin trans-coumarate, epicatechin trans-caffeic acid ester, epigallocatechin trans-coumarate and epigallocatechin trans-caffeic acid ester. The hydroxyl cinnamyl ester type catechins are prepared by the following steps: carrying out four steps of full acetylation on epicatechin and epigallocatechin, removal of acetyl on phenolic hydroxyl, silanizing of phenolic hydroxyl and removal of 3-acetyl, then respectively esterifying with acetylated caffeic acid or coumaric acid acyl chloride, and removing a protecting group. The preparation method of the four catechins is simple and mild inconditions, and can be completed under general experimental conditions. The four hydroxycinnamyl ester type catechins have a certain inhibition effect on the activity of alpha-glucosidase, can be usedfor hypoglycemic drugs, and have important significance in the fields of agriculture and medicine.
Owner:ANHUI AGRICULTURAL UNIVERSITY
Mixture of total tannin and epicatechin in wild buckwheat and extraction method and application thereof
InactiveCN109620864ADelicate shapeGood dispersionAntineoplastic agentsPlant ingredientsTanninMoisture
The invention provides a method for extracting a mixture of total tannin and epicatechin in wild buckwheat, and belongs to the technical field of pharmaceutical preparations. According to the method,the tannin and the epicatechin in the wild buckwheat are extracted more completely by defining the specific particle size of the wild buckwheat pulverized and the temperature of hot water in the suspension process, and the transfer rate of effective substances and the yield of spray drying products are improved. At the same time, the spray drying products are more fine in form, good in dispersibility and low in moisture by limiting the specific relative density and combining the special purification technology of macroporous adsorption resin and the spray drying technology, the obtained mixture of the total tannin and the epicatechin is good in stability, the filling capsule quality is good, and the mixture is easy to absorb by a patient.
Owner:HUAYI PHARMA
Apple peel polyphenol extract for the prevention and the treatment of non-alcoholic fatty liver disease
PendingUS20220000959A1Avoid accumulationPreventing and treating insulin resistanceOrganic chemistryDigestive systemApple peelPancreatic hormone
The present document describes apple peel polyphenolic extract comprising a proanthocyanidin content of at least 15000 μg / g of dry weight, comprising about 30% to about 35% epicatechin content, and pharmaceutical composition comprising the apple peel polyphenolic extract. The present document also describes methods and use of the apple peel polyphenolic extract for preventing or treating conditions such as oxidative stress, inflammation and mitochondrial dysfunction of the liver, insulin resistance, intestinal endothelial tissue injury, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis (NASH), liver fibrosis, liver cirrhosis, and / or inhibition of de novo lipogenesis and β-oxidation of free fatty acids for preventing accumulation thereof in the liver. The present document also describes a process for extraction of at least a polyphenol content from dry apple peel powder.
Owner:LEAHY ORCHARDS
Novel analogues of epicatechin and related polyphenols
Owner:EPIRIUM BIO INC
Fresh rhizoma fagopyri dibotryis extract spray-dried particle decoction piece
InactiveCN108619250ASolution volumeSolve the costGranular deliveryPlant ingredientsMedicineSpray dried
The invention discloses a fresh rhizoma fagopyri dibotryis extract spray-dried particle decoction piece. A preparation method of the decoction piece comprises harvesting rhizoma fagopyri dibotryis, washing the fresh rhizoma fagopyri dibotryis, carrying out slicing, juicing and extraction, concentrating the extract, carrying out spray-drying, carrying out granulation and particle finishing and carrying out vacuum packing. The particle decoction piece has water content of less than 10%. The epicatechin (C15H14O6) content of the decoction piece is greater than or equal to 0.040%. The quality of the decoction piece is stable. The decoction piece can be boiled in a decoction or directly used into tablets or capsules so that carrying and clinical use are convenient.
Owner:徐自升
Composition comprising combination of epicatechin and Anti-cancer compound
InactiveCN110312709ALittle side effectsImprove efficacyOrganic chemistryMetabolism disorderMedicinal chemistryExcipient
Owner:SPHAERA PHARMA PVT
Application of catechin to preparation of animal feed additive and feed thereof
PendingCN114431340AIncrease food intakeImprove immunityAccessory food factorsWorking-up animal fodderBiotechnologyAnimal science
The invention provides application of catechin to preparation of an animal feed additive and feed, the catechin is one or more of epigallocatechin gallate, epigallocatechin, epicatechin and epicatechin gallic acid, and the catechin is applied to preparation of the feed additive for improving the physique of newborn animals. When the catechin animal feed additive is applied to prepare a catechin feed, the addition amount of catechin is 0.05-20% based on the total mass of the feed, nutrient element absorption of a parent body is increased, nutrient element absorption of a daughter in the parent body and formation of an immune system are promoted, nutrient element storage of the daughter is increased, the physique of a newborn animal is improved, the weight of the newborn animal is increased, and the survival rate of the newborn animal is increased. The survival rate of newborn animals is improved.
Owner:广州微特加生物工程有限公司
Process for synthesis of polyphenols
Owner:EPIRIUM BIO INC
Polyamide large bio-fiber containing cocoa active ingredients and preparation method of polyamide large bio-fiber
PendingCN113174648AGood compatibilityGood modification effectArtifical filament manufactureMonocomponent polyamides artificial filamentTea catechinCompatibilization
The invention discloses polyamide large bio-fiber containing cocoa active ingredients and a preparation method of the polyamide large bio-fiber. The preparation method comprises the following steps of S1, extracting cocoa epicatechin; S2, modifying the cocoa epicatechin; S3, preparing porous nano silicon dioxide particles; S4, modifying the porous nano silicon dioxide particles; S5, preparing a molecular nest; S6, modifying the molecular nest; S7, preparing master batch containing the molecular nest; and S8, preparing the polyamide large bio-fiber containing the cocoa active ingredients. According to the preparation method of the polyamide large bio-fiber containing the cocoa active ingredients, the compatibility of the epicatechin and polyamide fiber is good, the active ingredients are protected by a porous nano-particle molecular nest technology in the preparation process, the loss caused by a high-temperature process is reduced, and the modification effect is good. The immobilization degree is good, and the decline rate of the physical performance, the antibacterial performance and the antiviral performance is smaller than 9.7%.
Owner:BESTEE MATERIAL (TSINGTAO) CO LTD +2
Gel preparation for treating cervicitis and cervical erosion and preparation method thereof
InactiveCN104510767ADrug properties are stableQuick resultsAerosol deliveryOintment deliveryGel preparationSophocarpidine
The invention discloses a gel preparation for treating cervicitis and cervical erosion. The gel preparation is prepared from following raw materials: a total extract of radix sophorae flavescentis, a total extract of catechu, a high-molecular adhesive material, water and a dilute acid. The use amount of the total extract of the radix sophorae flavescentis is determined on the basis of sophocarpidine and sophoridine in the preparation. The use amount of the total extract of the catechu is determined on the basis of catechin and epicatechin in the preparation. A research result proves that the best main effective components, comprising the sophocarpidine, the sophoridine, the catechin and the epicatechin, in the total extracts of the radix sophorae flavescentis and the catechu have a synergistic effect on treatment when the effective components are used within an effective dose range through study of a use amount range of the components in the gel preparation, and on the basis of the research result, proportion of usage amounts of the effective components and auxiliary materials in the gel preparation is re-determined. The gel preparation is stable in drug properties and has advantages of being quick and definite in curative effects and being free of inhibition on beneficial bacteria colony in vagina.
Owner:广西壮族自治区花红药业集团股份公司
Synthesis of catechin and epicatechin conjugates
InactiveUS20140171631A1Sugar derivativesSugar derivatives preparationChemical synthesisMedicinal chemistry
Owner:NESTEC SA
Use of catechin and epicatechin compounds for up-regulation of expression level of microRNA-150
The invention belongs to the field of medicines or health products, and particularly relates to the use of catechin and epicatechin compounds in the preparation of drugs for up-regulating the expression level of microRNA-150. As found by researches, catechin, catechin gallate, gallocatechin, (-)-gallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallatecan up-regulate the expression level of the microRNA-150, and can be used for treating myocardial hypertrophy, hypertension, ischemic cardiomyopathy, myocardial infarction, arrhythmia, cancer or sepsis.
Owner:CATCH BIO SCI & TECH
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