Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

58 results about "Isonicotinic hydrazide" patented technology

Isoniazid (Isonicotinic Acid Hydrazide) Pharmacology: Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a highly specific agent, ineffective against other microorganisms.

Fluoroquinolone acetal isoniazone, and preparation method and application thereof

InactiveCN102827187ASmall side effectsReduce the chance of developing drug resistanceAntibacterial agentsOrganic active ingredientsOxygen atomSide effect
The invention discloses a fluoroquinolone acetal isoniazone, of which the chemical structure general formula is disclosed as Formula I shown in the description, wherein R1 is hydrogen atom or methyl group; R2 is hydrogen atom or amino group; R3 is hydrogen atom, methyl group, ethyl group, formacyl group, acetyl group, aroyl group or sulfonyl group; R4 is hydrogen atom or methyl group; and X is oxygen atom or sulfur atom. The fluoroquinolone isoniazone disclosed by the invention implements complementarity between the two anti-tuberculosis medicines fluoroquinolone and the isoniazide, lowers the toxic and side effect of the fluoroquinolone and the isoniazide, reduces the generation probability of drug resistance of Mycobacterium tuberculosis for the double-effect antimicrobial agent, and can be used as an anti-Mycobacterium tuberculosis medicine for brand-new structure development of medicinal active substances.
Owner:HENAN UNIVERSITY

Method for determining isoniazid by using quantum dot fluorescence quenching method

The invention belongs to the field of application of nano materials and relates to a method for determining isoniazid by using a quantum dot fluorescence quenching method. According to the method of the invention, cadmium telluride quantum dots are synthesized by means of aqueous-phase synthesis through adopting a two-step method so as to be used for the fluorescence detection of isoniazid content. The influence of a pH value, ion strength, a quantum dot dosage, reaction time and temperature on a reaction system is investigated, results show that when the concentration of the isoniazid rangesfrom 2.92*10<-5> to -1.02*10<-3>mol / L, the luminescence of the quantum dots in the system is obviously inhibited; the concentration of the isoniazid and the intensity of the luminescence presents a good linear relationship; the detection limit of the method is 4.826*10<-7>mol / L; the relative standard deviation of the method is 0.296% (n= 10); and the precision of the method is very good. The method provided by the invention has the advantages of simplicity, rapidity, low cost and good anti-interference capability, and can be directly used for detection and analysis. With the method adopted, asimple method for detecting isoniazid content can be realized; and research on the application of a quantum dot fluorescence detection method is expanded.
Owner:SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES

Isoniazide derivative, homogeneous enzyme immunoassay reagent and preparation method

The invention discloses an isoniazid derivative, a detection reagent and a preparation method, and relates to the technical field of biological detection. An isoniazid immunogen prepared from the isoniazid derivative has high immunogenicity, and an obtained antibody has strong specificity and high titer; an isoniazid enzyme-labeled conjugate in a homogeneous enzyme immunoassay reagent prepared from the derivative is connected with recombinant glucose-6-phosphate dehydrogenase modified by gene engineering; the detection sensitivity is remarkably improved, a sample with the concentration as lowas 5 ng / ml or below can be effectively detected, the specificity is high, and cross reaction with 62 common drugs is avoided; the homogeneous enzyme immunoassay reagent can realize high-throughput andrapid detection of isoniazid content on a full-automatic biochemical analyzer, and is stable in detection result, high in accuracy, simple in detection method and easy to realize, popularize and use.
Owner:长沙博源医疗科技有限公司

Substituted N-((1', 3'-azole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound and applications thereof

The invention discloses a substituted N-((1', 3'-azole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound represented by formula I, a preparation method thereof, and applications of the substituted N-((1', 3'-oxazole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound in preparation of antituberculous drugs. The substituted N-((1', 3'-azole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound possesses activity on mycobacterium tuberculosis-susceptible strains, and also possesses activity on strains with tolerance on traditional first-line antituberculous drugs such as isoniazide and rifampicin, and is a novel mycobacterium tuberculosis resistant compound with a promising application prospect.
Owner:MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI

Method for preparing medicine-carrying hydroxyapatite/poly glycolide-co-lactide (PLGA)/chitosan demixing microspheres

The invention discloses a method for preparing medicine-carrying hydroxyapatite/poly glycolide-co-lactide (PLGA)/chitosan demixing microspheres. The method comprises the following steps of: dissolving isoniazide in deionized water, adding hydroxyapatite powder, stirring in a dark place, and freeze-drying to obtain powder; mixing PLGA and the powder uniformly to obtain a hydroxyapatite/PLGA commixed solution containing the isoniazide; dissolving chitosan in an acetic acid aqueous solution to obtain a chitosan solution; mixing the chitosan solution and a polyvinyl alcohol aqueous solution to obtain a chitosan/polyvinyl alcohol solution; and pouring the hydroxyapatite/PLGA commixed solution containing the isoniazide into the chitosan/polyvinyl alcohol solution, stirring under vacuum, washingby using water, and freeze-drying to obtain the medicine-carrying hydroxyapatite/PLGA/chitosan demixing microspheres. The prepared medicine-carrying composite microspheres are regular in spherical shapes, uniform in particle size distribution, high in envelop rate of medicines, long in in-vitro medicine release time and small in burst release; and a preparation process is simple, raw materials are readily available, and industrialization is easy to realize.
Owner:广州智园生物科技有限公司

Benzothiazinone derivative, preparation method thereof and application of benzothiazinone derivative as antituberculosis drug

The invention discloses a benzothiazinone derivative, a preparation method thereof and application of the benzothiazinone derivative as an antituberculosis drug, which relate to a novel compound witha benzothiazinone skeleton. The compound has an inhibition effect on tubercle bacillus, particularly tubercle bacillus with clinical drug resistance. The benzothiazinone skeleton benzene ring is creatively changed, especially the substituent group is creatively changed to obtain a series of compounds, and an unexpected technical effect is achieved; the compound disclosed by the invention has an excellent inhibition effect on tubercle bacillus; compared with the existing clinical first-line drug isoniazide (MIC 0.5 muM), the reported compound activity has very great advantages, and more importantly, compared with the benzothiazinone antituberculosis drug pBTZ 169 in the existing research stage, the compound provided by the invention has a lower cLogP value and better druggability.
Owner:SUZHOU UNIV

Bacterium preservation culture medium and preparation method thereof

The invention relates to the technical field of strain preservation, in particular to a bacterium preservation culture medium and a preparation method thereof. The culture medium comprises the following components: based on 1000ml of the culture medium, 8 to 13 g of beef extract, 2 to 6 g of peptone, 0.2 to 0.5 g of cholate, 0.2 to 0.3 g of aluminum potassium sulfate, 2 to 5 g of malt extract powder, 3 to 7 g of yeast extract powder, 0.3 to 0.6 g of sodium chloride, 5 to 10 g of agar, 0.2 to 0.5 g of soluble ferric salt, 0.01 to 0.05 g of a calcium supplement, 0.02 to 0.05 g of D-cycloserine, 0.001 to 0.004 g of argentein, 0.01 to 0.02 g of vitamin K1, 0.1 to 0.3 g of casein phosphopeptides, 3 to 5 g of glucose, 1 to 2.5 g of lanthanum nitrate, 3 to 5 g of erythritol, 18 to 23 ml of glycerin, 0.1 to 0.2 mg of warfarin sodium tablets, 8 to 12 mg of isoniazide, and 75 to 85 ml of sterile defiberized sheep blood. The formula of the culture medium is rich and comprehensive in nutrient substances, the survival of the strain can be ensured, and the culture medium can still ensure the effectiveness of the strain even if the preservation environment temperature is greatly changed.
Owner:贵州安康医学检验中心有限公司

Preparation and application of novel chromatic fiber IAHF-PAR

The invention discloses a synthesis method of a chelate fiber IAHF and a synthesis method and application of an IAHF-PAR chromatic fiber. The synthesis method of the chelate fiber IAHF comprises the following step: the polyacrylonitrile chelate fiber IAHF is synthesized by taking a polyacrylonitrile fiber as a matrix and isoniazide as a ligand under the condition of a nitrogen protective atmosphere. The synthesis method of the chromatic fiber IAHF-PAR comprises the following steps: putting the polyacrylonitrile chelate fiber IAHF and PAR into a formaldehyde water solution, performing stirring and heating reflux under the condition of a nitrogen protective atmosphere for 2-6 hours, and ending the stirring reaction at 70 DEG C; and performing flushing with warm water, and performing drying to a constant weight to obtain the chromatic fiber IAHF-PAR. The polyacrylonitrile chelate fiber IAHF synthesized by the invention has a heavy metal ion adsorption capability, wherein the selective adsorbability on mercury ions is high, the adsorption capacity is high, and the adsorption rate is high; and the chromatic fiber IAHF-PAR is applicable to detection under different environments, and can be prepared into chromatic materials of different forms.
Owner:ZHEJIANG GONGSHANG UNIVERSITY

Preparation method of isoniazid

The invention discloses a preparation method of isoniazide, which adopts temperature control and proper increase of hydrazine hydrate feeding proportion for reaction, solves the problems of narrow temperature range and difficult operability and controllability of the traditional condensation reaction, widens the reaction temperature to 129-138 DEG C, and has high yield of isoniazide. Meanwhile, refining steps such as decoloration, washing and recrystallization are combined, so that the content of impurities in isoniazid is remarkably reduced, and the requirements of related evaluation work of crude drugs are met. The reaction temperature range is wide, the yield and purity of isoniazide are improved, and a larger selection range is provided for operability and controllability of industrial production of isoniazide.
Owner:GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products