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Vitamin-medicine composition and its use

A technology of vitamins and compositions, applied in the field of vitamin pharmaceutical compositions and their uses, can solve problems such as pain problems without a good solution, and achieve the effects of convenient clinical use, avoiding local necrosis, and good stability

Active Publication Date: 2005-07-13
吉林津升制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, vitamin B1, vitamin B6, and vitamin B12 have not been combined according to a specific ratio to make a medicine for use, and there is still no good way to solve the pain problem of this type of medicine during intramuscular injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Weigh thiamine nitrate (C 17 h 26 N 4 o 3 S 2 ·HNO 3 ) 20g, pyridoxine hydrochloride (C 8 h 11 NO 3 · HCl) 300g, vitamin B 12 (C 63 h 88 CoN 14 o 14 P) 25mg, can be made into 10000ml liquid medicine, finally made into 10000 freeze-dried powder injections. Take 50% of the prepared water for injection and add it to the preparation tank, add thiamine nitrate, pyridoxine hydrochloride, vitamin B 12 , after stirring and dissolving, add water for injection to the prepared amount, adjust the pH value to 3.2, and pass the intermediate inspection. In the drying box, the temperature of the freeze-drying box is rapidly reduced to -40°C, and the liquid is cooled for 1 hour to completely freeze it; after the liquid is completely frozen, the pressure in the freeze-drying box is reduced to 5 Pa, and the condenser is cooled. Let it cool down to -65°C; connect the freeze-drying box, condenser, and vacuum pump to sublimate the water in the liquid medicine into water vapor, ...

Embodiment 2

[0053] Weigh thiamine nitrate (C 17 h 26 N 4 o 3 S 2 ·HNO 3 ) 20g, pyridoxine hydrochloride (C 8 h 11 NO 3 · HCl) 300g, vitamin B 12 (C 63 h 88 CoN 14 o 14 P) 25mg, can be made into 15000ml liquid medicine, finally made into 10000 freeze-dried powder injections. Take 50% of the prepared water for injection and add it to the preparation tank, add thiamine nitrate, pyridoxine hydrochloride, vitamin B 12 , after stirring and dissolving, add water for injection to the prepared amount, adjust the pH value to 3.5, and the intermediate has passed the inspection. In the drying box, the temperature of the freeze-drying box is rapidly reduced to -35°C, and the liquid is cooled for 2 hours to completely freeze; Let it cool down to -70°C; connect the freeze-drying box, condenser, and vacuum pump to sublimate the water in the liquid medicine into water vapor, and make the water vapor frost on the condenser tube. When sublimating, the freeze-drying box shelf Heat slowly, keep...

Embodiment 3

[0055] Weigh thiamine nitrate (C 17 h 26 N 4 o 3 S 2 ·HNO 3 ) 30g, pyridoxine hydrochloride (C 8 h 11 NO 3 HCl) 600g, Vitamin B 12 (C 63 h 88 CoN 14 o 14 P) 30mg, can be made into 10000ml liquid medicine, finally made into 10000 freeze-dried powder injections. Take 50% of the prepared water for injection and add it to the preparation tank, add thiamine nitrate, pyridoxine hydrochloride, vitamin B 12 , after stirring and dissolving, add water for injection to the prepared amount, adjust the pH value to 3.8, and pass the intermediate inspection. In the drying box, the temperature of the freeze-drying box is rapidly reduced to -42°C, and the liquid is cooled for 2 hours to make it completely frozen; Let it cool down to -68°C; connect the freeze-drying box, condenser, and vacuum pump to sublimate the water in the liquid medicine into water vapor, and make the water vapor frost on the condenser tube. When sublimating, the freeze-drying box shelf Slowly heat, keep the...

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PUM

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Abstract

The present invention relates to vitamin medicine composition, and is especially one kind of medicine composition compounded with vitamin B1, vitamin B6 and vitamin B12 and its use in treating peripheral nerve injury, polyneuritis, trigeminal neuralgia, ischialgia, isonicotinyl hydrazine poisoning and other diseases. These three kinds of vitamins are synergistic in regulating body's metabolism and maintaining body's important physiological function. The medicine preparation is preparation into freeze dried powder for injection with high stability and is intravenous instilled to reduce pain.

Description

technical field [0001] The present invention relates to a vitamin pharmaceutical composition and its application, in particular to a vitamin B 1 , Vitamin B 6 , Vitamin B 12 A pharmaceutical composition composed of three B vitamins, and its use in the treatment of peripheral nerve injury, multiple neuritis, trigeminal neuralgia, sciatica, sciatica, isoniazid poisoning, pregnancy, radiation sickness, and antineoplastic drugs It is used for vomiting, seborrheic dermatitis, pernicious anemia, nutritional anemia and other diseases. Background technique [0002] B vitamins especially B vitamins 1 , Vitamin B 6 , Vitamin B 12 It plays an important role in meeting the nutritional needs of the human body and maintaining the normal metabolism and physiological functions of the human body. Due to various reasons, the lack of B vitamins often causes various diseases, so B vitamins are widely used in clinical practice. [0003] Vitamin B 1 Also known as thiamine, its chemical str...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/714A61P7/06A61P15/00A61P25/02A61P35/00A61P39/02A61P43/00
Inventor 张志
Owner 吉林津升制药有限公司
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