Slow released compound antituberculotic preparation containing synergist
An anti-tuberculosis and synergistic technology, which is applied in the field of compound anti-tuberculosis drug sustained-release preparations, can solve the problems of difficulty in obtaining effective bactericidal concentration, increased dose side effects, unsatisfactory effects of multidrug-resistant tuberculosis, etc., and achieves convenient drug application, The effect of reducing the course of treatment, unique treatment effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0123] Put 90, 90 and 80 mg of polyphenylpropane (p-carboxyphenylpropane (p-CPP): sebacic acid (SA) at 20:80) copolymers into (A), (B) and (C) three Add 100 ml of dichloromethane to each container, dissolve and mix well, add 10 mg rifampicin, 10 mg ofloxacin, 10 mg rifampicin and 10 mg ofloxacin respectively, re-shake and spray dry Microspheres for injection containing 10% rifampicin, 10% ofloxacin and 10% rifampicin and 10% ofloxacin were prepared by this method. Then suspend the microspheres in physiological saline containing 15% mannitol to prepare the corresponding suspension-type sustained-release injection. The viscosity of the injection is 300cp-600cp (at 20°C-30°C). The drug release time of the sustained release injection in physiological saline in vitro is 15-20 days, and the drug release time in mice subcutaneous is about 30-40 days.
Embodiment 2
[0125] The method step of being processed into slow-release injection is identical with embodiment 1, but difference is that contained anti-tuberculosis active ingredient and weight percentage thereof are:
[0126] (a) 2-50% rifampicin, rifamycin, rifapentine or ributin with 2-50% cycloserine, ofloxacin, ciprofloxacin, sparfloxacin or curly Combinations of mycins;
[0127] (b) 2-50% streptomycin, kanamycin, amikacin or amikacin and 2-50% cycloserine, ofloxacin, ciprofloxacin, sparza A combination of star or capreomycin;
[0128] (c) 2-50% of isoniazid, pyrazinamide, ethambutol or sodium p-aminosalicylate and 2-50% of cycloserine, ofloxacin, ciprofloxacin, sparfloxacin or Combinations of capreomycin;
[0129] (d) 2-50% combination of rifampicin and pyrazinamide with 2-50% cycloserine, ofloxacin, ciprofloxacin, sparfloxacin or capreomycin;
[0130] (e) 2-50% of ethionamide or prothione in combination with 2-50% of cycloserine, ofloxacin, ciprofloxacin, sparfloxacin or capreo...
Embodiment 3
[0135] Put 70 mg of polylactic acid (PLGA, 75:25) with a peak molecular weight of 65,000 into three containers (A), (B) and (C) respectively, and then add 100 ml of dichloromethane to each, dissolve and mix well , add 30mg rifapentine, 30mg ofloxacin, 15mg rifapentine and 15mg ofloxacin into three containers respectively, shake up again and use spray drying method to prepare 30% rifapentine, 30 % ofloxacin, 15% rifapentine and 15% ofloxacin microspheres for injection. The dried microspheres are suspended in physiological saline containing 1.5% sodium carboxymethylcellulose to prepare the corresponding suspension-type sustained-release injection. The viscosity of the injection is 300cp-600cp (at 20°C-30°C). The drug release time of the slow-release injection in physiological saline in vitro is 10-15 days, and the drug release time in mice subcutaneous is about 20-30 days.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com