The invention relates to a traditional Chinese medicine ointment, a preparation method and application thereof. The raw materials of the traditional Chinese medicine ointment include: bezoar, the rhizome of Chinese goldthread, the root bark of shaggy-fruited dittany, pepper, radix sophorae flavescentis, barbados aloe, golden larch bark, the tuber of stemona, borneol, menthol crystal and vaseline; and the raw materials are crushed and mixed to prepare the traditional Chinese medicine ointment. The traditional Chinese medicine ointment for the treatment of skin disease can penetrate the thicker skin or realize the desquamation of stratum corneum to have quick efficacy, can quickly kill the surface causative agent, destroy the breeding environment for bacteria, have targeting medicinal efficacy, can clear the toxic substance in blood, inhibit the synthesis of muggy stasis tissue, regulate the metabolic disturbance of cells due to long-term use of hormone drugs, enhance the active ingredients of anti-relapse anti-immune factors, reproduce the newly-generated immune substances, improve skin micro-circulation, repair damaged skin tissues and increase the resistance and immunity.