The invention belongs to the field of pharmaceutical chemicals, and particularly relates to a
bromhexine hydrochloride synthesis method. The synthesis method comprises following steps: step A, carrying out a reduction reaction between 2-amino-3,5-dibromobenzaldehyde and a
reducing agent to generate 2-amino-3,5-dibromobenzyl
alcohol; step B, reacting 2-amino-3,5-dibromobenzyl
alcohol obtained in the step A with
thionyl chloride to generate 2,4-bromo-6-chloromethyl
aniline; and step C, carrying out an
amination reaction between 2, 4-bromo-6-chloromethyl
aniline obtained in the step B and N-methyl cyclohexyl amine, and then carrying out a salt forming reaction with an HCl salifying
reagent to obtain
bromhexine hydrochloride. According to the preparation method,
thionyl chloride is only used as a reactant; in addition, the steps are simple, the intermediates obtained in the steps A and B do not need to be purified and directly used for the next step of reactions, therefore, the
working hours required by the whole production
route are remarkably shortened, the final yield is increased by 5% or above, and the method is particularly suitable for large-scale production.