Stable bromhexine hydrochloride sodium chloride injection composition
A technology of sodium chloride injection and bromhexine hydrochloride, which is applied in the field of bromhexine hydrochloride sodium chloride injection composition and its preparation, can solve problems such as low stability, low safety, and complicated preparation process, and achieve The effect of ensuring sterility
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Embodiment 1~5
[0034] The preparation of embodiment 1~5 bromhexine hydrochloride sodium chloride injection
[0035] prescription:
[0036] Example
Example 1
Example 2
Example 3
Example 4
Example 5
bromhexine hydrochloride
20mg
40mg
60mg
40mg
60mg
Sodium chloride
9g
9g
9g
9g
9g
Tartaric acid: glacial acetic acid (weight ratio)
0.5:1
0.7:1
0.8:1
1:1
1:1
water for injection, added to
1000ml
1000ml
1000ml
1000ml
1000ml
[0037] Preparation Process:
[0038] Add the prescribed amount of bromhexine hydrochloride and sodium chloride into the water for injection, adjust the pH to 4.0 with the prescribed ratio of tartaric acid and glacial acetic acid, stir to dissolve, adsorb on activated carbon, filter to remove carbon, fine filter, subpackage, and sterilize at 121°C 15 minutes, pack, promptly get bromhexine hydrochloride sodium chloride injection of the p...
Embodiment 6-9
[0039] The preparation of embodiment 6-9 (comparative example) bromhexine hydrochloride sodium chloride injection
[0040] prescription:
[0041]
[0042] Preparation Process:
[0043] Add the bromhexine hydrochloride and sodium chloride of the prescription amount in Example 6-9 into the water for injection, adjust the pH to 4.0 with tartaric acid, glacial acetic acid, citric acid, and lactic acid respectively, stir and dissolve, absorb with activated carbon, filter to remove carbon, and purify Filter, pack, sterilize at 121 DEG C for 15 minutes, pack, and obtain the bromhexine hydrochloride sodium chloride injection of the comparative example.
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