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Compound cefaclor preparation and preparation method

A technology for cefaclor and preparation, which is applied to the preparation and preparation of compound cefaclor, and the field of drug preparation and preparation, can solve the problem of no compound cefaclor granules and the like, and achieves low turbidity, good taste and enhanced water solubility. Effect

Inactive Publication Date: 2011-07-06
汤明昌 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently there is no supply market for compound cefaclor granules

Method used

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  • Compound cefaclor preparation and preparation method
  • Compound cefaclor preparation and preparation method

Examples

Experimental program
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Embodiment Construction

[0062] Weigh 250g of cefaclor, 8g of bromhexine hydrochloride, 160g of sodium carboxymethylcellulose, 80g of povidone, 120g of sodium citrate, 4g of micronized silica gel, 3370g of sucrose powder, and 8g of sweet orange essence, and prepare the compound according to the following steps Cefaclor Granules:

[0063] Step 1: Take 3 times the amount of sodium carboxymethyl cellulose with distilled water at 60°C to moisten the sodium carboxymethyl cellulose. After fully swelling, add distilled water 20 times the amount of sodium carboxymethyl cellulose and stir for 30 minutes. Filter (the mesh is greater than 200 mesh), add povidone to the filtrate, stir for 30 minutes, filter (the mesh is greater than 200 mesh);

[0064] The second step: add cefaclor, bromhexine hydrochloride, sodium citrate and sweet orange essence to the solution of the first step, and stir thoroughly for 20 minutes;

[0065] The third step: take 842.5g of powdered sugar and make syrup according to the quality r...

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Abstract

The invention relates to a preparation of a medicine and a preparation method, in particular to a compound cefaclor preparation and a preparation method, and belongs to the technical field of pharmacy. The preparation is characterized by being prepared by adding a proper amount of pharmaceutical excipients into 25 to 35 weight parts of medicine, namely cefaclor and 0.5 to 1.5 weight parts of bromhexine hydrochloride, wherein the cefaclor is calculated based on anhydrous cefaclor, and the bromhexine hydrochloride is calculated based on bromhexine; and the excipients consist of a suspending agent, a flocculating agent, a flavoring agent and a flow aid. The invention provides a formula capable of improving the dissolubility and suspension stability of medicines and the mouthfeel of finished products, and a preparation technology.

Description

technical field [0001] The invention relates to a preparation and a preparation method of a medicine, in particular to a preparation and a preparation method of compound cefaclor, belonging to the technical field of medicine manufacture. Background technique [0002] Cefaclor, the English name is Cefaclor, the molecular formula is: C 15 h 14 ClN 3 o 4 S.H 2 O molecular weight is 385.82, chemical name: (6R,7R)-7-[(R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5-thia-1-aza Bicyclo[4,2,0]oct-2-ene-2-carboxylic acid monohydrate. [0003] The molecular structural formula of cefaclor is as follows: [0004] [0005] Properties: white, off-white or light yellow powder or crystalline powder; slightly smelly, bitter taste. [0006] Solubility: Slightly soluble in water, almost insoluble in methanol, ethanol, chloroform or dichloromethane. [0007] Specific rotation: +105° to +120°. [0008] Absorption coefficient: The absorption is measured at a wavelength of 264nm, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545A61K31/137A61K9/16A61P11/02A61P11/04A61P11/00A61P31/04
Inventor 汤明昌
Owner 汤明昌
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