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Production method of bromhexine hydrochloride

A technology of bromhexine hydrochloride and glacial acetic acid, which is applied in the field of medicine and chemical industry, can solve problems such as low recovery rate, low recovery rate, and difficulty in solvent recovery and treatment, and achieve the effects of reducing costs, reducing moisture content, and reducing waste of labor

Active Publication Date: 2013-10-02
ZHEJIANG WANBANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In order to improve the quality stability of bromhexine hydrochloride and improve the safety and effectiveness of medication for patients, the patent CN102775316A adopts the method of decolorizing in a mixed solvent of ethanol and n-butanol, and cooling and crystallizing after adding acetonitrile aqueous solution to the filtrate, with a yield of 87 ~ 90%, content 99.5 ~ 90.8%, and the obtained new crystals are combined with excipients such as mannitol and pH regulators such as citric acid to improve the quality stability of bromhexine hydrochloride. The above method adopts mixed solvent decolorization and Adding a special solvent, acetonitrile, for crystallization brings difficulties in solvent recovery and treatment; patent CN 102924295A uses a method of crystallization with an alcohol solvent with a water content of more than 30%, the recovery rate is greater than 60%, the optimal condition can reach more than 80%, and the product purity reaches 99.8% More than, the new crystalline crystal stability that obtains and the solubility in water are better than the crystal form that prior art produces, help to prepare bromhexine hydrochloride injection dosage form, but this method recovery rate is on the low side, has increased mother liquor treatment quantity and Difficulty; recently published patent CN103145564A adopts decolorization in ethanol and methanol mixed solvent, and cools and crystallizes after adding dropwise acetone aqueous solution in the filtrate, and there is also the problem of difficult recovery and low recovery rate of a large amount of mixed solvent

Method used

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  • Production method of bromhexine hydrochloride
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  • Production method of bromhexine hydrochloride

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Preparation of crude N-methyl-N-cyclohexyl-2-amino-3,5-dibromobenzylamine hydrochloride.

[0041] Feeding ratio:

[0042] raw material name Quantity(Kg) raw material name Quantity(Kg) reduction 94 toluene 3±1 Glacial acetic acid 49±1 30% hydrochloric acid 48±5 N-Methylcyclohexylamine 114±1 water 48±5 ethanol 125±1

[0043] In a 300L electric heating reaction pot, put N-methylcyclohexylamine, add the reducing substance under stirring, stir to dissolve, then slowly add glacial acetic acid dropwise, and finally add toluene; open the pipeline valve of the distillation water separation device, cooling water and refrigeration refrigerant Corresponding to the valve, heat the jacket to raise the temperature to reflux and divide the water; then slowly increase the temperature until the end of the reaction (the end of the water division), and control the temperature in the pot at the end of the reaction to about 170-180°C...

Embodiment 2

[0046] Preparation of crude N-methyl-N-cyclohexyl-2-amino-3,5-dibromobenzylamine hydrochloride.

[0047] Feeding ratio:

[0048] raw material name Quantity(Kg) raw material name Quantity(Kg) reduction 188 toluene 5±1 Glacial acetic acid 98±1 30% hydrochloric acid 96±5 N-Methylcyclohexylamine 228±1 water 96±5 Methanol 250±1

[0049] In a 500L electric heating reaction pot, put N-methylcyclohexylamine, add the reducing substance under stirring, stir to dissolve, then slowly add glacial acetic acid dropwise, and finally add toluene; open the pipeline valve of the distillation water separation device and the cooling water and refrigerant Corresponding to the valve, heat the jacket to heat up to reflux for water separation; then slowly increase the temperature until the end of the reaction (end of water separation), and finally control the temperature in the pot to be about 170-180°C.

[0050] Preheat the 1000L salt-formin...

Embodiment 3

[0052] Condensation-salt-forming section: prepare crude N-methyl-N-cyclohexyl-2-amino-3,5-dibromobenzylamine hydrochloride.

[0053] Feeding ratio:

[0054] raw material name Quantity(Kg) raw material name Quantity(Kg) reduction 188 toluene 5±1 Glacial acetic acid 98±1 30% hydrochloric acid 96±5 N-Methylcyclohexylamine 228±1 water 96±5 acetone 300±1

[0055] In a 500L electric heating reaction pot, put N-methylcyclohexylamine, add the reducing substance under stirring, stir to dissolve, then slowly add glacial acetic acid dropwise, and finally add toluene; open the pipeline valve of the distillation water separation device and the cooling water and refrigerant Corresponding to the valve, heat the jacket to heat up to reflux for water separation; then slowly increase the temperature until the end of the reaction (end of water separation), and finally control the temperature in the pot to be about 170-180°C.

[0056] Preh...

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Abstract

The invention relates to a production method of bromhexine hydrochloride. The production method is characterized by comprising the following steps of: 1) carrying out a condensation reaction between 3,5-dibromo-2-aminobenzalcohol and N-methyl cyclohexane in the presence of glacial acetic acid as a catalyst, thereby generating N-methyl-N-cyclohexyl-2-amino-3,5-dibromobenzylamine; 2) salifying the generated N-methyl-N-cyclohexyl-2-amino-3,5-dibromobenzylamine with hydrochloric acid to obtain bromhexine hydrochloride; and 3) decoloring and refining the obtained bromhexine hydrochloride in an alcoholic solution to obtain a pure product, wherein an azeotropic water-carrying agent is added to the condensation reaction in the step 1), and water in the reaction mixed solution in the reaction process is removed immediately through distillation.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, in particular to a production method of bromhexine hydrochloride, an expectorant. Background technique [0002] Bromhexine hydrochloride, alias bromhexine hydrochloride, bisoping, bixiaophlegm, bromhexine hydrochloride, English name is Bromhexine Hydrochloride, chemical name is N-methyl-N-cyclohexyl-2-amino-3, 5-Dibromobenzylamine hydrochloride, molecular formula: C 14 h 20 Br 2 N 2 ·HCl, molecular weight: 412.60, structural formula: [0003] [0004] Bromhexine hydrochloride is a commonly used expectorant at home and abroad. It has a strong mucolytic effect, can decompose and break polysaccharides and cellulose in sputum, inhibit the synthesis of acidic mucopolysaccharide proteins, reduce sputum viscosity, and facilitate coughing. It is clinically suitable for patients with chronic bronchitis, asthma, bronchiectasis, silicosis and other diseases with sticky phlegm that is di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C211/52C07C209/16
Inventor 丁跃庭江月华叶美土赵守明
Owner ZHEJIANG WANBANG PHARMA
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