Bromhexine hydrochloride compound and medicine composition thereof
A bromhexine hydrochloride compound technology, applied in the field of medicine, can solve the problems of unfavorable drug long-term storage, poor stability of bromhexine hydrochloride, and rapid reduction of active ingredient content, so as to improve drug safety, good stability, and not easy to change Effect
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Embodiment 1
[0032] The preparation of the bromhexine hydrochloride composition is as follows: take 100 g of the bromhexine hydrochloride crude product, add a volume ratio of 8.5:1.5 ethanol:n-butanol solution whose volume is 10 times the weight of the bromhexine hydrochloride crude product, and stir at 40° C. Dissolve; after the bromhexine hydrochloride crude product is dissolved, add 0.3 times of activated carbon for decolorization for 30 minutes, filter; stop heating the filtrate, cool the filtrate to 23°C at a speed of 1.2°C / min, keep the temperature and add dropwise the volume of the bromhexine hydrochloride crude product The water: acetonitrile solution with a volume ratio of 3 times the weight of 4:6, the dropwise addition is at a constant speed of 8 minutes under the stirring speed of 14rmp; min, lower the temperature to 8°C, let stand for 17 hours, filter, wash twice with a 6:4 ethanol: n-butanol solution, each time the volume is 0.4 times the weight of the crude bromhexine hydroch...
Embodiment 2
[0035] The preparation of the bromhexine hydrochloride composition is as follows: take 100 g of the bromhexine hydrochloride crude product, add a volume ratio of 8.5:1.5 ethanol:n-butanol solution whose volume is 10 times the weight of the bromhexine hydrochloride crude product, and stir at 40° C. Dissolve; after the bromhexine hydrochloride crude product is dissolved, add 0.3 times of activated carbon for decolorization for 30 minutes, filter; stop heating the filtrate, cool the filtrate to 20°C at a speed of 1.2°C / min, keep the temperature and add dropwise the volume of the bromhexine hydrochloride crude product 3 times the weight of water: acetonitrile solution with a volume ratio of 4:6, the dropwise addition is at a constant speed of 8 minutes at a stirring speed of 15rmp; after dropping, stir and cool down, and the stirring and cooling is at a speed of 2.3°C / min, lower the temperature to 5°C, let stand for 18 hours, filter, wash twice with a 6:4 ethanol: n-butanol soluti...
Embodiment 3
[0038] The preparation of the bromhexine hydrochloride composition is as follows: take 100 g of the bromhexine hydrochloride crude product, add a volume ratio of 8.5:1.5 ethanol:n-butanol solution whose volume is 10 times the weight of the bromhexine hydrochloride crude product, and stir at 40° C. Dissolve; after the bromhexine hydrochloride crude product is dissolved, add 0.3 times of activated carbon for decolorization for 30 minutes, filter; stop heating the filtrate, cool the filtrate to 25°C at a speed of 1.2°C / min, keep the temperature and add dropwise the volume of the bromhexine hydrochloride crude product Water: acetonitrile solution with a volume ratio of 3 times the weight of 4:6, the dropwise addition is at a constant speed of 8 minutes under the stirring speed of 12rmp; min, lower the temperature to 10°C, let stand for 16 hours, filter, wash twice with a 6:4 ethanol:n-butanol solution, each time the volume is 0.4 times the weight of the crude product of bromhexine ...
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