Bromhexine hydrochloride soluble powder for livestock and poultry, and preparation method and application thereof

Abstract

The invention belongs to the field of livestock and poultry medicines, and discloses bromhexine hydrochloride soluble powder for livestock and poultry and a preparation method and application thereof.The soluble powder is prepared by uniformly mixing bromhexine hydrochloride, a cosolvent and a soluble filler, and can be used as a medicine for treating respiratory tract infection of the livestockand poultry. Through reasonable proportioning, beta-cyclodextrin and a stabilizer do not need to be added, and it can still be guaranteed that the prepared bromhexine hydrochloride soluble powder hasgood solubility and stability; the cosolvent and the bromhexine hydrochloride are uniformly mixed, so that the solubility of the bromhexine hydrochloride is further increased, the problem of poor solubility of the bromhexine hydrochloride is solved, and the bromhexine hydrochloride soluble powder is suitable for the livestock suffering from respiratory infection.

Description

technical field [0001] The invention belongs to the field of livestock and poultry medicine, and relates to a soluble powder for livestock and poultry, in particular to bromhexine hydrochloride soluble powder for livestock and poultry, a preparation method and application thereof. Background technique [0002] Bromhexine hydrochloride, also known as bromhexyl ammonium, is a semi-synthetic hydrochloride salt of argonine derivatives, first synthesized by Keck in 1963, and listed in China in 1973. Bromhexine hydrochloride is a white or off-white crystalline powder, odorless, slightly soluble in methanol, slightly soluble in ethanol, and very slightly soluble in water. Bromhexine hydrochloride can directly act on bronchial glands to promote the release of lysosomes from mucus-secreting cells, causing the mucosugar fibers in sputum to differentiate and crack, and can also inhibit the synthesis of acid glycoproteins in mucus glands and goblet cells, making them Secretes less visc...

AI Technical Summary

Problems solved by technology

And livestock and poultry are still using florfenicol soluble powder and tiamulin fumarate soluble powder etc. as medicine for treating respiratory diseases. appeared

A Chinese invention patent application 201610776470.6 discloses a bromhexine hydrochloride soluble powder and its preparation method and application, and discloses that the bromhexine hydrochloride soluble powder can be used to treat respiratory diseases of livestock and poultry, but according to the raw materials, dosage and The preparation method can't make bromhexine hydrochloride soluble powder that can be used by livestock and poultry very well

Most of the solubilizing effects disclosed in this patent are not good, and wherein tartaric acid is generally used as an antioxidant or flavoring agent in food, and can also be used as a raw material for preparing other medicines, and its solubilizing effect is not ideal; Succinic acid, also known as succinic acid, is mainly used as flavoring agent and preservative in food, and is mainly used as a raw material for the synthesis of other drugs in medicine. Its solubility is average, and its effect as a cosolvent is not ideal; Drug intermediates can also be used as cosolvents in the heat welding process, but they are not suitable for use as cosolvents in medicines; fumaric acid, also known as fumaric acid, is generally used in the preparation of antidote dimercaptosuccinic acid, and is used in medicine and Intermediates of fine chemicals such as optical bleaching agents, mainly used in food to adjust acidity and antisepsis, not used as a cosolvent

All the stabilizers disclosed in this patent are not suitable for the preparation of soluble powders. Among them, PVP, as a stabilizer, is generally used to prevent the agglomeration of colloids. It is very easy to absorb moisture and agglomerate, and is not suitable for the preparation of solid preparations. Stabilizer; poloxamer is a new type of polymer non-ionic surfactant, generally used as an emulsifier or solubilizer, and used as a stabilizer to prepare liquid preparations, thereby maintaining the clarity of liquid preparations, not suitable for use Used in the preparation of solid preparations; sodium lauryl sulfate is an anionic surfactant that is slightly toxic to the human body, has good emulsification, foaming and water solubility, and can be used as an emulsifier in food or medicine. See use as a stabilizer

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