55 results about "Arginine ethylester" patented technology

A controlled release biocidal salt of a first component comprises a cation of a Nα—(C1-C22)alkanoyl di-basic amino acid alkyl(C1-C22)ester cationic biocidal molecule and a second component comprising an anion of a monomeric anionic molecule having insignificant biocidal activity. The salt is characterized such that when the salt is exposed to an aqueous medium, the salt partially dissolves thereby releasing biocidal ions in an amount sufficient to exceed the MIC or MBC of a target bacteria being controlled, and further characterized as leaving a residual reservoir of undissolved salt capable of releasing more biocidal ions as the salt is consumed or otherwise removed from the environment encompassing the target bacteria. The preferred cationic biocidal molecule comprises Nα-lauroyl-L-arginine ethyl ester (“LAE”).

Antimicrobial film based on biopolymers, in particular cellulose and / or protein, or uncoated or coated textile material, and also an antimicrobial sponge or an antimicrobial sponge cloth based on regenerated or precipitated cellulose are provided. The film, the sponge or the sponge cloth is impregnated or coated with at least one α-amino acid ester, the α-amino group of which is acylated with a fatty acid, or the corresponding hydrochloride, and the α-amino acid ester is bound covalently, optionally also ionically, to the film, the sponge or the sponge cloth. The acylated α-amino acid ester is preferably N-lauroyl-L-arginine ethyl ester monohydrochloride (LAECl), N-lauroyl-L-arginine methyl ester monohydrochloride (LAMCl) or N-lauroyl-L-lysine ethyl ester hydrochloride (LLECl). The film is preferably in the form of a flexible tube and is provided as casing for foods, especially sausage products.

The invention discloses a medical antibacterial hydrogel dressing and a preparation method thereof. The hydrogel dressing is prepared from the following raw materials: thiolated chitosan, sodium glycerophosphate hydrate, carbomer, oxidized sodium alginate, L-arginine ethyl ester dihydrochloride, theophylline, glycine fumarate, L-carnitine powder, stachyose, hydroxyethyl methylacrylate, tri(propylene glycol) diacrylate, ginkgo flavonol, polyhexamethylene biguanidine, povidone iodine, alcoholic extract of herba andrographitis, triethanolamine and de-ionized water. The hydrogel dressing prepared by the invention can achieve inhibitory rates 91% and 94% or above on pseudomonas aeruginosa and staphylococcus aureus separately, and the hydrogel dressing has a broad-spectrum antibacterial property and a durable antibacterial effect; and in addition, the hemostasis time of the dressing is just 9-18s and healing time is shorter than 10d, and healed regenerated skin has a smooth and delicate surface; therefore, the hydrogel dressing is excellent in wound healing capacity and quite good in healing effect.

The invention discloses a preparation method of ethyl lauroyl arginine hydrochloride, which belongs to the technical field of organic synthesis. The method comprises: reacting L-arginine hydrochloride with lauroyl chloride in a mixed solvent composed of water and organic solvent A, after the reaction is completed, adjusting the pH value to 5-9, centrifuging and drying to obtain lauroyl arginine; React lauroyl arginine with ethanol and thionyl chloride, and evaporate to dryness to obtain the crude product after the reaction is completed; dissolve the crude product in organic solvent B, add alkaline aqueous solution to adjust the pH value to 5-8, stir, stand still, and take The organic layer was cooled to crystallize, centrifuged and dried to obtain the refined product of ethyl lauroyl arginate hydrochloride. The preparation method provided by the invention has the advantages of simple operation, few by-products, easy separation, easy drying and easy crushing, etc., and the main impurities in the product are effectively removed during the preparation process, and high-purity fine particle lauroyl arginine B can be obtained. Ester hydrochloride, suitable for large-scale production, the product is widely used in food and cosmetic industries.

The invention relates to the technical field of cosmetics and particularly relates to efficiently atomized spray having a function of skin care and a preparation method thereof. The spray has small droplet diameters and a narrow droplet diameter spectrum. The droplet movement speed is slow and the liquid use amount per unit area is uniform. The spray has a good skin care effect. The spray comprises purified water, glycerol, 1, 3-butanediol, 1, 3-propanediol, 1, 2-hexanediol, 1, 2-pentanediol, betaine, allantoin, polyglyceryl-10-isostearate, PPG-26-butanol polyether-26 / PEG-40 hydrogenated castor oil / water, saccharide isomeride / water / citric acid / sodium citrate, PCA cocoyl arginine ethyl ester, caprylic / capric triglyceride, nicotinamide, purslane extract, water / hydrolyzed royal jelly protein / butanediol, water / glycerol / 1, 2-hexanediol / 1, 2-pentanediol / beta-glucan, menthol lactate / menthol, methyl diisopropyl propionamide, and octanoyl hydroxamic acid / 1, 3-propanediol. The spray is used through a spray bottle, has good atomization effects, high efficiency of deposition on the skin and has good skin care effects.

Antimicrobial film based on biopolymers, in particular cellulose and / or protein, or uncoated or coated textile material, and also an antimicrobial sponge or an antimicrobial sponge cloth based on regenerated or precipitated cellulose are provided. The film, the sponge or the sponge cloth is impregnated or coated with at least one α-amino acid ester, the α-amino group of which is acylated with a fatty acid, or the corresponding hydrochloride, and the α-amino acid ester is bound covalently, optionally also ionically, to the film, the sponge or the sponge cloth. The acylated α-amino acid ester is preferably N-lauroyl-L-arginine ethyl ester monohydrochloride (LAECI), N-lauroyl-L-arginine methyl ester monohydrochloride (LAMCI) or N-lauroyl-L-lysine ethyl ester hydrochloride (LLECI). The film is preferably in the form of a flexible tube and is provided as casing for foods, especially sausage products.

The invention discloses a preparation method and application of an epsilon-polylysine-containing antimicrobial composition. The epsilon-polylysine-containing antimicrobial composition comprises the following components of 1 to 20% of epsilon-polylysine, 5 to 35% of other antimicrobial agent, and 60 to 90% of solvent and synergistic additive, wherein the antimicrobial agent is a mixture of one or two of caprylhydroximic acid, levulinic acid, sodium levulinic acid, p-hydroxyacetophenone, ethyl lauroyl arginate, tropolone and octenidine; the solvent and synergistic additive are mixture of water and one or at least two of 1,2-propanediol, methylpropanediol, 1,3-propanediol, 1,3-butanediol, 1,2-hexanediol, 1,2-pentanediol, 1,2-octanediol, 1,2-decanediol, polyethylene glycol, ethylhexylglycerinand propanediol carbonate. The epsilon-polylysine-containing antimicrobial composition can be dissolved into water, be convenient in adding and use, and can be widely applied to the fields of cosmetics, wet tissues, masks, washing and the like.

A disclosed kit for detecting activity of human tissue kallikrein is characterized by comprising: 1) an enzyme label plate coated by specific anti-human tissue kallikrein clone antibody; 2) a standard sample of fusion protein TK-4T1 of human tissue kallikrein; and 3) a BAEE (N-benzoyl-L-arginine ethyl ester hydrochloride 0 working solution. According to the kit, a method combining immunization and chemistry is employed, by utilizing the characteristic that human tissue kallikrein (TK) in a human urine or blood plasma sample can be combined with the specific antibody, TK is separated from the sample and further catalyzes a chemical reaction of a substrate N-benzoyl-L-arginine ethyl ester hydrochloride (BAEE).

The invention discloses a natural antibacterial detergent for lady clothes. The preparation method comprises the following steps that: a natural composition is developed which has strong antibacterialactivity on escherichia coli, candida albicans and staphylococcus aureus, namely tea tree essential oil, lemongrass essential oil and ethyl lauroyl arginate HCL; and when the natural antibacterial composition is used for laundry products, the natural antibacterial composition further comprises a surfactant, and the surfactant is cocamidopropyl betaine, lauryl glucoside and disodium cocoyl glutamate. The natural antibacterial detergent for lady clothes is developed on the basis, has super-strong capabilities of removing protein stains, removing blood stains and removing underwear secretion residues, has a high antibacterial rate on escherichia coli, staphylococcus aureus and candida albicans, and has an antibacterial rate of more than or equal to 99.9 percent after acting for 2 minutes; and moreover, the product is clear and transparent in appearance, high in natural component proportion, weakly acidic, mild and non-irritant.

This invention discloses a method of preservation of a food product comprising the step of adding 1) a first component comprising between 10 ppm and 1% of a biocidal salt of Nα—(C1-C22) alkanoyl di-basic amino acid alkyl (C1-C22) ester cationic biocidal molecule with an anionic counterion, and 2) a second component comprising from 10 ppm to 1% by weight an acyl monoglyceride, directly to a food product. The preferred cationic biocidal molecule comprises Nα-lauroyl-L-arginine ethyl ester (“LAE”). The invention also discloses the method of preservation of a food product using salts of a Nα—(C1-C22) alkanoyl di-basic amino acid alkyl (C1-C22) ester cationic biocidal molecule and an anionic counterion with or without a monoglyceride of a fatty acid, whereby the packaging film is compounded with the salts and the optional monoglyceride of a fatty acid.

The invention discloses a preparation method of ethyl lauroyl arginate hydrochloride, and belongs to the technical field of the preparation of food additives. The preparation method comprises the following steps that according to the charging molar ratio, which is not less than (2 to 1), of ethyl arginate dihydrochloride to lauryl chloride, dropwise adding the lauryl chloride into an ethyl arginate solution, and carrying out a reaction; after the reaction is finished, adding ethyl acetate, extracting, and separating an oil phase and a water phase; washing the oil phase through a saturated sodium chloride aqueous solution, and evaporating a solvent, so that the ethyl lauroyl arginate hydrochloride is obtained; replenishing the ethyl arginate dihydrochloride with an amount equivalent to the consumption in the former reaction into the water phase, dropwise adding the lauryl chloride with an equal molar weight, continuously reacting, and completing post treatment, wherein the step can be subsequently repeated to carry out multiple times of reaction. Through using the excessive ethyl arginate dihydrochloride in the initial step and then repeatedly utilizing the water phase containing the ethyl arginate dihydrochloride, a raw material is maintained to be excessive in each reaction and not only can the conversion ratio of the lauryl chloride be improved but also a high-purity product can be obtained.

The present invention relates to a process for preparing hydrochloride salt of N-fatty acyl substituted amino acid ethyl ester. Said process includes the steps of: dissolving L-arginine ethyl ester dihydrochloride in distilled water with continuous agitation for a period of about 10 to about 20 minutes to obtain a clear solution; lowering the temperature of the clear solution to about 5° C. to about 10° C. to obtain a cooled solution; adjusting the pH of the cooled solution in the range of about 7 to about 8 by adding sodium hydroxide solution; adding at least one organic solvent to the clear solution with continuous agitation to obtain an intermediate mixture; condensing the intermediate mixture by simultaneously adding an acid halide and 20% sodium hydroxide solution at a temperature of about 7° C. to about 9° C. and at a pH in the range of about 7.2 to about 7.5 for about 2 hours to obtain a mixture; raising the temperature of the mixture to about 18 to about 20° C. followed by addition of sodium hydroxide to adjust the pH of the mixture to about 7.3; warming the mixture at a temperature of about 25 to about 30° C. to obtain a resultant mixture containing organic phase and aqueous phase; separating the organic phase and aqueous phase of the resultant mixture by settling the mixture; and distilling the organic phase under vacuum at a temperature of about 70° C. to about 75° C. to obtain a hydrochloride salt of ethyl lauroyl arginate.

The invention relates to a foam private care no-clean antibacterial liquid and a preparation method thereof. The foam private care no-clean antibacterial liquid comprises the following raw material components: a bactericidal active component, a surfactant, a humectant and a pH regulator, wherein the bactericidal active component is composed of chlorhexidine gluconate, benzethonium chloride, ethyllauroyl arginate hydrochloride and triethyl citrate. The foam private part care no-clean antibacterial liquid provided by the invention can effectively kill common pathogenic bacteria including candida albicans, escherichia coli and staphylococcus aureus at the private parts of women, has extremely high use safety, can mildly care the hygiene of the private parts of the women, and enables the skinto keep fresh and comfortable.

The invention provides a crispness-keeping and cold-damage-preventing fresh-keeping method for Longtan pearl plums, and belongs to the technical field of fruit fresh keeping. The method comprises thefollowing steps: (1) pre-picking treatment is conducted, specifically, a mixed liquid medicine consisting of zeatin, N alpha-lauroyl-L-arginine ethyl ester hydrochloride (LAE) and Ca(NO3)2 is sprayedonce every other week three weeks before picking; (2) post-picking treatment is conducted, specifically, gradient cooling precooling treatment is conducted, fumigation treatment is conducted on 1-methylcyclopropene and chlorine dioxide in sequence while precooling; after precooling is conducted, an ethylene absorbent is put, a fresh-keeping bag and a box cover are sealed, storage is conducted in acontrolled atmosphere box or a refrigeration house at -1.5-0 DEG C, and temperature changing treatment is conducted every 14 d; and (3) pre-warehouse-out treatment is conducted, specifically, different gradient temperatures are adopted for re-fermentation treatment. By adopting the method, the storage period of the Longtan pearl plums can reach three months, the storage resistance of pearl plum fruits can be remarkably maintained, the sensory quality and hardness of the fruits can be maintained, and the occurrence of cold damage to the fruits can be effectively reduced.

The invention discloses a production and purification process of ethyl lauroyl arginate hydrochloride. The process comprises the following steps: step A, esterfying in ethyl alcohol to obtain ethyl arginate dihydrochloride; step B, adding lauroyl chloride into ethyl arginate dihydrochloride in an organic system in the presence of organic alkali, and carrying out condensation to obtain ethyl lauroyl arginate; step C, acidifying ethyl lauroyl arginate into hydrochloride in the organic system, and purifying the product; and step D, carrying out recrystallization and precipitating solid out, and drying the solid to obtain ethyl lauroyl arginate hydrochloride. Through the production and purification process of ethyl lauroyl arginate hydrochloride, the hydrolysis of the product can be effectively avoided; the product is high in stability in industrial production; the mole yield of the product is 97% or higher; the purity of the product is 97% or higher; compared with the existing productiontechnology, the molar yield and the purity of the product are obviously improved.

The present invention is related to synthesis of highly pure cationic surfactant products by eliminating or reducing impurities generation that has beset prior art. This is achieved through the N-acylation of ester of amino acid and its inorganic salts or its organic salts (e.g. amino acid or hydrochloride of amino acid or sulfate of amino acid or acetate of amino acid etc.) in non-hydrolytic or nearly non-hydrolytic reaction conditions involving mono or biphasic reaction system with fatty acid halide (C4 to C20), under moderate uniform basic condition yielding high purity N-acyl substituted amino acid ester, particularly ethyl lauroyl arginate. The present process achieves pH control through process strategy rather than the measurement and control steps. This ambient temperature process is stable through a range of temperature variation eliminating rigid low temperature control.

The invention relates to a natural edible hair shampoo and a making method thereof. The natural edible hair shampoo comprises the following components: fatty acyl lactyl-lactic acid, arginine, plant monoolein, plant phospholipid, epsilon-polylysine, lauroyl arginine ethyl hydrochloride, inulin, polyhydric alcohols, and the like. The edible hair shampoo is capable of preventing static electricity,improving hair smoothness and preventing pore blocking and is good in flowability at a low temperature; the classical idea of conventional cationic hair protection (with serious irritation) is turnedover, natural anionic type washing and protection main materials without irritation are used, the shampoo is based on a non-closed protein peptide / low HLB (hydrophile-lipophile balance) value oilinessagent film formation smoothing system, a cationic high polymer / silicon oil hair protection mode with intensive negative effects is avoided, original ecological environments of hair and scalp can be protected, the product meets the smooth experience of organic silicon oil finally, and a novel way is created for research and development of edible cosmetic type cleaning and protection two-in-one hair shampoos.

A skin lubrication lotion that functions as a skin rubbing anti-friction barrier compound to prevent skin rashes from burning of skin from excessive rubbing, said lotion comprising: a lubricant; a skin numbing ingredient including lidocane; a vitamin ingredient, wherein the vitamin is selected from the group consisting of vitamin A, C, E, D or B 12; an ingredient that causes human skin to tingle, wherein the tingling ingredient is selected from the group consisting of menthol and L-arginine ethyl ester; wherein the skin lotion further consisting essentially of about: 71% water, 0.070% sodium benzoate, 0.070% potassium Sorbate, 0.180% citric acidanhydrous (FCC, USP), 14.200% glycerine 99.7%, 14.200% propylene glycol USP, 0.140% Xanthan gun 80 mesh, and 0.140% guar gun 250 (food grade).

The invention relates to a fruit and vegetable freshness-keeping agent characterized by comprising a potassium sorbate solution or a N-alpha-lauroyl-L-arginine ethyl ester hydrochloride LAE solution as an active ingredient; and the invention further provides a preparation method of the fruit and vegetable freshness-keeping agent. The preparation method of the fruit and vegetable freshness-keepingagent comprises the following steps: (1) preparing a water-soluble potassium sorbate solution; (2) preparing a N-alpha-lauroyl-L-arginine ethyl ester hydrochloride LAE solution; and (3) spraying the two solutions 0-3 days before harvest, either used as single agents or used simultaneously with intervals between. Compared with the prior art, the invention has the following advantages: the fruit andvegetable freshness-keeping agent can be used for pre-harvest treatment of kiwi fruits so as to improve edible safety of the kiwi fruits; moreover, the fruit and vegetable freshness-keeping agent isalso capable of slowing down decline of sensory quality and nutritional quality of kiwi fruits so as to prolong shelf lives of the kiwi fruits.

Fruit and vegetable composite preservative comprises a compound solution of N-alpha-lauroyl-L-arginine ethyl ester dihydrochloride LAE and plant essential oil, wherein the mass ratio of the LAE and the plant essential oil is from 0.002 to 12. The preparation method of the fruit and vegetable composite preservative comprises the following steps: (1) dissolving the LAE into pure ethanol to obtain mother liquid A; (2) adding the mother liquid A into pure water at the temperature of 20 to 25 DEG C and stirring uniformly to obtain an LAE aqueous solution; (3) dissolving the plant essential oil intothe pure ethanol to obtain mother liquid B; (4) adding the mother liquid B into an emulsifier to prepare plant essential oil emulsion; and (5) adding the plant essential oil emulsion into the LAE aqueous solution and mixing uniformly to obtain the LAE-plant essential oil compound solution. The fruit and vegetable composite preservative is sprayed before fruits and vegetables are picked, so the quality of cherries is improved, the proportion of high-quality fruits is increased, the postharvest preservation and fresh-keeping method which is adopted for a long time is reformed and the fruit andvegetable composite preservative is green and safe.

The present invention relates to an ethyl lauroyl arginate hydrochloride microcapsule and preparation technology thereof. The preparation technology is prepared by: using ethyl lauroyl arginate hydrochloride as core materials; using starch sodium octenyl succinate and cyclodextrin as wall materials, proportionally mixing the wall materials with anticaking agents, dispersants and aqueous phase antioxidants, and homogenizing and spray drying the mixture to obtain ethyl lauroyl arginate hydrochloride microcapsule powder. There is no need to add any organic solvents in the preparation process of the ethyl lauroyl arginate hydrochloride microcapsule, and the function activity of obtained products can be kept; and the ethyl lauroyl arginate hydrochloride microcapsule is characterized by increased solubility at low temperature and greatly improved usability and water solubility. The ethyl lauroyl arginate hydrochloride microcapsule is more conducive to processing, transportation and storage, and is excellent antiseptic materials. The ethyl lauroyl arginate hydrochloride microcapsule produced by the preparation technology is high in yield, and suitable for large-scale preparation to realize the continuous and large-scale production.

The invention relates to a disinfectant for fruit and vegetable, and a preparation method thereof. The disinfectant for fruit and vegetable comprises the following raw materials: a bactericidal activecomponent, a surfactant, a humectant, a chelating agent, a pH regulator and water, wherein the bactericidal active component is composed of benzalkonium chloride, polyhexamethylene biguanide hydrochloride and ethyl lauroyl arginate hydrochloride. The disinfectant of the invention has the following beneficial effects: the bactericidal active component composed of three raw materials, i.e., benzalkonium chloride, polyhexamethylene biguanidine hydrochloride and ethyl lauroyl arginate hydrochloride, is added Into the disinfectant for fruit and vegetable; through compounding of the three raw materials, the bactericidal effect of the disinfectant can be remarkably improved, a bactericidal spectrum is wide, and no drug resistance is generated; the disinfectant has a good killing effect on escherichia coli, staphylococcus aureus, listeria monocytogenes and fruit and vegetable putrefying bacteria; bacteria on the surfaces of vegetable and fruit can be effectively removed; and the disinfectanthas the characteristics of good bactericidal effect, high safety and easiness in cleaning.

The invention belongs to the technical field of medicine detection and relates to a method for quantitatively detecting the content of leonurine in blood plasma. The method is characterized by adopting the high performance liquid chromatography-mass spectrometry technology, using benzoyl arginine ethyl ester as an internal standard of a detected substance, using a method of precipitating the proteins with perchloric acid to pretreat the blood plasma sample and calculating the blood concentration of leonurine in the blood plasma by using the peak area according to an internal standard method, wherein liquid chromatography adopts Agilent ZorbaxSB-C18 column as the stationary phase, the acetonitrile / ammonium acetate buffer solution mixed solution is used as the mobile phase and gradient elution is carried out; mass spectrometry adopts an electrospray ionization source; leonurine is quantified by adopting multiple reaction monitoring; and the lowest limit of quantification of leonurine in the method reaches 4ng / mL. The method has the following beneficial effects: the method has strong sample detection specificity and high sensitivity and is simple and convenient to operate; all the textual research indexes of methodology can meet relevant technical requirements of Chinese pharmacopoeia; and the method can be used for pharmacokinetics research after oral administration of leonurine.

The invention discloses a method for detecting the activity of residual trypsin in a cell product. The method is characterized in that trypsin is used to catalyze hydrolysis of N-benzoyl-L-arginine ethyl ester hydrochloride into N-benzoyl-L-arginine hydrochloride and ethanol, and detecting the absorbance of the hydrolyzed reaction system at a wavelength of 253 nm in order to determine the activity of trypsin. The new trypsin activity detection method is obtained when the optimum reaction temperature is 37 DEG C and the optimum detection time is 25 min after the reaction starts; and the method has high sensitivity, so the method can be used to detect the activity of the residual trypsin in the cell product. The method for detecting the activity of residual trypsin in the cell product is simple, sensitive and practical.

An antimicrobial composition, a process of making the composition, and a method of using the composition for attaining a longer shelf life for poultry. The antimicrobial composition comprises buffered vinegar (BV) and lauramide arginine ethyl ester (LAE).

The invention discloses a developer for PET / CT (positron emission tomography / computer tomography). The developer is N-(2-<18>F-fluoro propionyl)-L-arginine, and auxiliary radicals, namely 4-nitrobenzene-2-<18>F-propionate and L-arginine ethyl ester dihydrochloride, carry out amiation reaction and are further hydrolyzed to obtain the developer. The developer has the advantages that the developer is better in targeting for lung cancers in human lung cancer bearing nude mouse models and is lower in brain-muscle extraction ratio and excellent in safety and stability; development effects of the developer are superior to development effects of <18>F-FDG (fluorodeoxyglucose), and the developer is long in development hold time; the <18>F-FP-Arg developer can possibly become an excellent lung cancer developer and a developer for various other cancers except for cancers of livers and kidneys in the future.

The invention provides an economic and environment-friendly range hood cleaning agent and a preparation method thereof, wherein alkyl dimethyl betaine, N-sodium lauroyl sarcosine, cocamidopropyl betaine and lauroyl arginine ethyl ester hydrochloride are used as surfactants, and the cleaning agent has excellent dirt-removing power; lauric acid acyl dimethylacrylamide plays an antistatic role, and dust absorption is avoided. Hydroxypropyl methyl cellulose has the function of preventing redeposition of dirt, and can suspend expanded perlite, talcum powder and alum sludge to avoid sedimentation. Coconut oil can improve the antibacterial performance of a cleaned range hood. Isothiazolinone serving as a preservative can avoid the corrosion problem of the range hood after being cleaned. The expanded perlite, the talcum powder and the alum sludge can improve the friction force between the cleaning agent and the range hood and facilitate the removal of the dirt on the range hood; meanwhile, theantibacterial performance of the range hood can be improved. The cleaning agent can swell, emulsify and clean oil stains of the range hood through the synergistic effect of the components, and has nocorrosion effect on the range hood.