110 results about "Benzethonium chloride" patented technology

Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including a cationic antiseptic such as biguanides and bisbiguanides such as chlorhexidine and its various salts including but not limited to the digluconate, diacetate, dimethosulfate, and dilactate salts; polymeric quaternary ammonium compounds such as polyhexamethylenebiguanide; silver and various silver complexes; small molecule quaternary ammonium compounds such as benzalkoium chloride and alkyl substituted derivatives; di-long chain alkyl (C8-C18) quaternary ammonium compounds; cetylpyridinium halides and their derivatives; benzethonium chloride and its alkyl substituted derivatives; and octenidine. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and / or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and / or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).

A microbicidal composition containing: (a) 1,2-benzisothiazolin-3-one; and (b) at least one microbicide selected from among benzalkonium chloride, benzethonium chloride, benzyl alcohol, caprylyl glycol, chlorphenesin, 2,2′-dithiobis(N-methylbenzamide), diazolidinyl urea, ethylenediamine tetraacetic acid, ethylparaben, imidazolidinyl urea, methylparaben, phenoxyethanol, linoleamidopropyl PG-dimonium chloride phosphate, cocamidopropyl PG-dimonium chloride phosphate, propylparaben, cis-1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride, dehydroacetic acid or its salts, benzoic acid or its salts, sodium hydroxymethylglycinate and zinc pyrithione.

The present invention is directed to the use of benzethonium chloride, alone or in combination with phenoxyethanol or phenyl ethyl alcohol, to provide anti-microbial activity in pharmaceutical compositions. The present invention also provides methods of using benzethonium chloride, alone or in combination with phenoxyethanol or phenyl ethyl alcohol, to inhibit microbial growth in pharmaceutical compositions.

An antimicrobial moisturizing composition includes benzethonium chloride or benzalkonium chloride, a non-benzyl cationic surfactant, and an aqueous carrier. The composition of the present invention provides a significant and unexpected reduction of irritation, inflammation, dryness and / or redness, all issues associated with known alcohol-based skin disinfectants. In particular, the present invention provides a stable, aesthetically-pleasing, long-lasting, and moisturizing antimicrobial composition that is substantially free of ethanol, polysorbates, and anionic compounds that are known to inhibit the activity of benzethonium chloride or benzalkonium chloride.

A microbicidal composition of 1,2-benzisothiazolin-3-one; and at least one of benzalkonium chloride, benzethonium chloride, benzyl alcohol, caprylyl glycol, chlorphenesin, diazolidinyl urea, ethylparaben, imidazolidinyl urea, methylparaben, phenoxyethanol, linoleamidopropyl PG-dimonium chloride phosphate, cocamidopropyl PG-dimonium chloride phosphate, propylparaben, cis-1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride, dehydroacetic acid or its salts, benzoic acid or its salts, and sodium hydroxymethylglycinate.

An article of manufacture and a method directed to application of aromatic releasing compositions impregnated within substrates such as non-woven paper materials (e.g., wipes, paper towels) and dispensable cloth materials (e.g., gauze or a thin fabric of silk, linen, or cotton materials) for providing relief from cold, allergies, sinus and symptoms associated with respiratory disorders, the aromatic releasing compositions including the following: Menthol; Camphor; Eucalyptus oil; Cedarleaf Oil; Myristica Oil; Peppermint Oil; Lavender oil; Methyl Salicylate; Naproxen; Nutmeg Oil and Thymol; Beclometasone dipropionate; Benzethonium chloride with base solution consisting of Emollients, Emulsifiers and Moisturizer; Deionized Water; Vegetable Oil; Dicaprylyl Carbonate; Glyceryl Oleate; Polyglyceryl-2 Dipolyhydroxystearate; Cetearyl Isononanoate; Ceteareth-20; Cetearyl Alcohol; Glyceryl Stearate; Glycerin; Cetyl Palmitate; Ceteareth-12, Lauryl Glucose Carboxylate; Lauryl Glucoside; Sodium Citrate; Citric Acid; Benzethonium Chloride 0.05%; Ethylene diamine tetra acetic acid; Phenoxyethanol; Methylparaben; Propylparaben; 2-bromo-2-nitropropane-1,3-diol; and subcombinations thereof. In further embodiments, the compositions impregnated within substrate further include one or more topical actives, and are useful for providing relief from cold, allergies, sinus and symptoms associated with respiratory disorders, as well as repelling common virus and bacteria.

The present invention is directed to a preserved liquid aqueous pharmaceutical composition comprising one or more etherified cyclodextrin derivatives; one or more water-soluble preservatives; preferably selected from the group consisting of sorbic acid or salts thereof, preferably sodium sorbate, potassium sorbate, calcium sorbate; benzoic acid or salts thereof, preferably sodium benzoate; benzalkonium chloride; benzethonium chloride; cetylpyridinium chloride; sodium metabisulfite; sodium acetate; parabenes and salts thereof, preferably methylparabene, ethylparabene, propylparabene, butylparabene, butylparabene sodium; or combinations thereof; and at least one pharmaceutically active compound which is poorly water-soluble, very poorly water-soluble or water-insoluble. The liquid aqueous pharmaceutical composition provides an acceptable solubility of the pharmaceutically active compound, such as pimobendan, in aqueous solution whereby the water-soluble preservatives retain their effectiveness in the presence of the etherified cyclodextrin derivatives allowing the use in an oral administration form.

The invention relates to disinfection gel and a preparing method of the disinfection gel. The disinfection gel is prepared from the following ingredients in percentage by mass: 0.05 to 0.2 percent of benzethonium chloride, 30 to 80 percent of ethanol, 0.1 to 1 percent of thickening agents, 3.0 to 8.0 percent of humectants, 0.1 to 1 percent of PH regulators and the balance deionized water. The disinfection gel provided by the invention uses the benzethonium chloride and the ethanol as clean anti-corrosion bactericide, and the effects of fast sterilization and permanent sterilization and bacteriostasis are achieved. The thickening agents, the humectants and the PH regulators are added, so that good gel performance is realized. Compared with the prior art, the disinfection gel has the advantages that the recipe is reasonable; the performance is stable; the use is convenient; the hand feeling is good; a good sterilization effect is achieved; the injury to the skin is avoided; no potential health risk exists; the disinfection gel is particularly applicable to medical aspect hand washing and hand wiping sterilization work.

A cleaning composition for treating and removing stains from an object and for removing residue following a clean-up after a chemical or biological weapons attack. The composition uses ethanol, isopropyl alcohol, ethylene glycol mixed with one or more salts, such as bromides and chlorides, a chelator and a dispersant, mixed with water. The preferred salts are myristyltrimethylammonium bromide and benzethonium chloride, the chelator is tetrasodium salt ethylenediamine of tetraacetic acid, and the dispersant is polyvinyl alcohol.

A stable, self-preserving, antimicrobial, composition suitable for the treatment of a variety of dermal as well as subcutaneous conditions. The compositions include as an active ingredient a quaternary ammonium compound, preferably benzethonium chloride, potentiated and synergized with menthyl lactate cooling agent in a cationic carrier. Optionally, a phenoxyethanol preservative and chlorhexidine digluconate antibacterial agent may be used to assist in enhancing the activity. The compositions kill a broad spectrum of gram-negative and gram-positive bacteria, fungus and yeasts. The compositions are used as first aid skin treatments and as skin sanitizers to help prevent bacterial contamination of minor cuts, scrapes and burns. The compositions are particularly useful when applied to the skin after hair removal in that they additionally cool, soothe and moisturize the skin. The compositions may also serve as a base vehicle in which additional skin care ingredients may be added to provide additional functionality to the compositions.

The invention discloses a sterilizing preservative composition containing benzethonium chloride and an application thereof. The sterilizing preservative composition is composed of 1-50wt% of benzethonium chloride, 0.5-10wt% of antifungal agent, 5-30wt% of synergistic agent and 10-80wt% of solvent. The composite has little foams when being prepared and used, has excellent sterilization (bacteriostat) activity, can be widely applied to personal care products, such as cosmetics, wet tissues, nursing lotion, liquid soap and the like and especially can satisfy the requirement of the sanitary wet tissues and antibacterial liquid soap on the sterilizing rate on bacteria and fungus.

The invention relates to a preparation method for low-molecular heparin originated from a new species. The preparation method comprises the following steps: (1) fully dissolving heparin sodium prepared from raw materials bovine lungs, ox intestines and / or goat intestines in water, and adding a benzethonium chloride solution to prepare heparin benzethonium chloride salt; (2) dissolving the heparin benzethonium chloride salt in dichloromethane, adding benzyl chloride, stirring the mixture to react, reducing the temperature and adding a sodium acetate methanol solution to prepare heparin benzyl ester; (3) dissolving the heparin benzyl ester in water, adding sodium hydroxide, reducing the temperature after reaction, adjusting the pH to neutral, adding sodium chloride, and then adding alcohol to prepare an enoxaparin sodium crude product; and (4) dissolving the enoxaparin sodium coarse product in water, and purifying and drying the mixture to obtain enoxaparin sodium. According to the preparation method provided by the invention, the condition that the low-molecular heparin can be obtained by heparin sodium prepared from bovine lungs, ox intestines and goat intestines is found for the first time, and the prepared low-molecular heparin is lower in molecular weight compared with that of existing low-molecular heparin, so that the biological activity is higher and the low-molecular heparin has a wide market application prospect.

The invention discloses modified corn starch toilet powder and a preparation method thereof. The toilet powder is prepared from the following raw materials in parts by weight: 80 to 100 parts of modified corn starch, 1 to 10 parts of zinc oxide, 1 to 5 parts of silica, 1 to 5 parts of tricalcium phosphate and 0.01 to 0.1 part of benzethonium chloride. The preparation method comprises the followingsteps: firstly, weighing each raw material according to a formula amount; then adding all of the weighed raw materials of the modified corn starch, the zinc oxide, the silica, the tricalcium phosphate and the benzethonium chloride into a stirring pot to stir and uniformly mix; filtering by a screen; finally, checking whether the filtered mixture reaches requirements, and after the mixture reachesthe requirements, carrying out canning and packaging to complete preparation of a modified corn starch toilet powder product. The toilet powder disclosed by the invention avoids the safety hazard oftalcum powder and essence on human bodies and particularly babies, also avoids the defect that the talcum powder can only absorb sweat, but cannot take a skin care effect, and meanwhile, also effectively improves a case of non-ideal fineness and smooth effect of common corn starch.

The invention provides a vagina-cleaning wet tissue, which can sterilize and disinfect the vagina. Solution of the vagina-cleaning wet tissue for women consists of lactic acid, benzethonium chloride, propylene glycol, sorbitol, medicinal menthol and water. The wet tissue is obtained by soaking cut, sterilized and disinfected cotton spunlace in prepared solution for 3 to 5 hours and sealing and aseptically packaging the soaked cotton spunlace. The wet tissue prepared from the medicinal solution is packaged hermetically and is easy to take and convenient to use. The aim of cleaning vagina can be fulfilled by using one piece of wet tissue in a toilet in no need of a cleaning utensil or the avoiding of the place.

The present invention is enoxaparin and its preparation process, and features that the preparation process includes the following steps: dissolving sodium heparin in water, dissolving benzethonium chloride in water, mixing these two kinds of solution to react, vacuum suction filtering, washing the solid with water and stoving to obtain quaternary ammonium salt of heparin; dissolving the salt in dichloromethane, adding benzyl chloride to react, adding methanol solution of sodium acetate to produce precipitate, suction filtering, washing the solid with methanol and stoving to obtain heparin benzyl ester; dissolving heparin benzyl ester in 0.1N water solution of sodium hydroxide, adding sodium chloride, membrane filtering after dissolving, adding methanol to separate out precipitate, suction filtering, washing and stoving solid to obtain coarse enoxaparin sodium product; and purifying to obtain refined enoxaparin sodium product. The present invention has low production cost and high product quality.

The invention discloses a preparation method of an anti-wrinkle antibacterial irritation-free shirt fabric finishing agent and belongs to the field of fabric finishing agents. According to the preparation method, chitosan liquid reacts with linoleic acid and linolenic acid to obtain aliphatic chitosan; coconut oil is extracted out of copra; the aliphatic chitosan and the coconut oil are mixed; then aloe juice, cymbopogon essence oil, dextrin and benzethonium chloride are added into the aliphatic chitosan and the coconut oil to be mixed to obtain mixed liquid; the mixed liquid is mixed with malic acid, sodium hypophosphite, triethanol amine, butane tetracarboxylic acid and ethylene glycol in a heated mode to obtain the finishing agent. The prepared finishing agent is better in anti-wrinkle effect to fabric, high in wrinkle rebound resilience, small in strength loss, good in antibacterial performance, lasting in antibacterial time, free of irritation to a human body, safe and environment-friendly; the antibacterial property can reach 92% or more, the antibacterial property can reach 80% or more after fabric is washed for 100 times repeatedly, and a wrinkle recovery angle is 200 degrees or more.

The invention discloses a method for rapidly starting normal-temperature short-cut nitrification of municipal sewage by benzethonium chloride, and belongs to the technical field of biological sewage treatment; through primary soaking treatment on activated sludge through benzethonium chloride, AOB and NOB are inhibited to a certain extent, but the activity of the AOB can be preferentially recovered, ammonia nitrogen is not converted into nitrate nitrogen any more after ammonia nitrogen is converted into nitrite nitrogen, and short-cut nitrification is successfully realized. The method comprises the steps: inoculating activated sludge subjected to whole-course nitrification into a sequencing batch biochemical reactor, and carrying out benzethonium chloride soaking treatment on the activatedsludge after aeration is finished, wherein the benzethonium chloride concentration is 50-80 mg / L, and the soaking time is 12-24 h. The activated sludge is only soaked once, the reactor returns to normal operation, and when the nitrite accumulation rate (NAR) reaches 90% or above, normal-temperature short-cut nitrification of the municipal sewage is formally started. Short-cut nitrification is realized by a new inhibitor, and the inhibitor can quickly start normal-temperature short-cut nitrification of the municipal sewage.

The present invention relates to antimicrobial sanitizing compositions for use as skin sanitizers, especially sanitizers for the hands and feet, and air sanitizers and deodorisers. The sanitizing compositions comprise a combination of three ammonium compounds (ie. an alkoxy silyl ammonium compound, a benzalknonium chloride or benzethonium chloride and a polymeric biguanide) in a non-ionic surfactant carrier. The non-ionic surfactant system comprises an alcohol ethoxylate and an alkylglucoside or alkylpolyglycoside. Methods of use of the compositions are also described.

The invention discloses a gold and silver surface anti-oxidation and anti-color-change protecting agent and a preparation method and application thereof, and belongs to the technical field of gold andsilver plating layer protecting agents. The protecting agent comprises the following components in parts by weight: 15-30 parts of color change preventing agents, 10-15 parts of film forming agents,3-8 parts of alcohol ether solvents, 30-50 parts of emulsifying agents, 2-5 parts of benzethonium chloride, 5-10 parts of carboxylic acid type deoxidants, 1-3 parts of corrosion inhibitors, 0.5-1 partof antioxidants, 1-3 parts of brightening agents, and 5-20 parts of water. The prepared protecting agent can form double layers of protecting films to effectively prevent oxidation of gold and silverplating layers by air and corrosion by acid and alkali; meanwhile, the surface corrosion and color change resistance of the plating layers is improved; the brightness of the plating layers is improved; the performances of higher brightness and efficiency are given to the plating layers; the protecting agent also can be applied to surface protection of copper substrates, and the effect can rival chromium salt protecting films; the copper surface colors can be not changed for a long time; the effect of low poison is achieved; and the treatment process is simple.

The invention belongs to the field of disinfectants, the invention discloses a foam type sterilizing, disinfecting and air purifying agent as well as a preparation method and application thereof. Theproduct is mainly prepared from the following components in percentage by weight: 0.10-0.40% of peroxyacetic acid, 0.15%-0.60% of hydrogen peroxide, 0.05%-0.10% of a quaternary ammonium salt type cationic surfactant, 0.05%-0.10% of benzethonium chloride, 0.10%-0.20% of alkyl glycoside, 0.10%-0.20% of a stabilizer, 0.20%-0.60% of glycerol and 97.80%-99.25% of water. The product has stable performance, wherein the retention time of the formed sterilization disinfectant foam in the environment is long and the sterilization and disinfection action time is long. The product is low in cost, has a good air purifying effect, is non-toxic, pollution-free and residue-free, has a broad-spectrum sterilizing effect, is applied to prevention and control of the novel coronavirus, can effectively kill thenovel coronavirus and cut off a virus transmission path, and can also effectively kill escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, bacterial spores and other viruses and microorganisms.

Efficient bacteriostatic PU synthetic leather is disclosed. The synthetic leather is prepared from following raw materials by weight: 80-100 parts of polyurethane resin, 80-100 parts of dimethylformamide, 5-10 parts of sodium carboxymethyl cellulose, 1-2 parts of coconut oil, 1-2 parts of castor oil, 0.5-1 part of disodium EDTA, 0.2-0.5 part of sodium dodecylpoly(oxyethylene) sulfate, 0.2-0.5 part of a honeysuckle flower extract, 0.5-1 part of water-soluble lanolin, 1-2 parts of chitosan, 0.5-1 part of aluminium chloride, 1-2 parts of seaweed meal, 0.2-0.5 part of benzethonium chloride, 3-6 parts of color paste and 2-4 parts of modification additives. The synthetic leather has good water absorption and air permeability performance and comfort, and is capable of effectively inhibiting growth and reproduction of bacteria on surfaces of the synthetic leather, providing a clean and sanitary environment and benefiting human health maintaining.

The invention relates to a foam private care no-clean antibacterial liquid and a preparation method thereof. The foam private care no-clean antibacterial liquid comprises the following raw material components: a bactericidal active component, a surfactant, a humectant and a pH regulator, wherein the bactericidal active component is composed of chlorhexidine gluconate, benzethonium chloride, ethyllauroyl arginate hydrochloride and triethyl citrate. The foam private part care no-clean antibacterial liquid provided by the invention can effectively kill common pathogenic bacteria including candida albicans, escherichia coli and staphylococcus aureus at the private parts of women, has extremely high use safety, can mildly care the hygiene of the private parts of the women, and enables the skinto keep fresh and comfortable.

The invention relates to repairing type disinfection liquid capable of prompting healing of wounds. The repairing type disinfection liquid is mainly prepared from the following components in percentage: 0.01 to 2.0 percent of single and double-strand compound quaternary ammonium salts or benzethonium chloride, 0.01 to 2.0 percent of guanidine, 0.0 to 1.0 percent of modified chitosan, 2.0 to 5.0 percent of small molecular alcohol, 1.0 to 10.0 percent of skin care agent and 0.1 to 2.0 percent of anti-sensitivity agent. A plurality of single and double-strand quaternary ammonium salts are mixed synergistically, so that the sterilizing ability is enhanced; guanidine is compounded, so that the sterilizing wide spectrum is enhanced; healing and recovery of the wounds are facilitated through film formation protection performance and biocompatibility of chitosan; meanwhile, stimulation and discomfort on the wound surface can be lowered through anti-sensitivity factors. The repairing disinfection liquid can be widely applied to medical use and civil use, and has high social benefit and economic benefit.

The invention relates to a bacteriostatic and deodorant cat litter composition and a preparation method thereof. The bacteriostatic and deodorant cat litter composition is prepared from the following raw materials in percentage by mass: 10-40% of plant fiber powder, 10-25% of corn flour, 15-30% of corn starch, 0.05-0.5% of a bacteriostatic agent, 0.2-1.5% of an adhesive, 0.5-2% of a deodorant, 10-26% of an auxiliary agent and 5-15% of water, wherein the bacteriostatic agent is selected from a compound of at least two of iodopropynyl butyl carbamate, benzethonium chloride and imidazolidinyl urea; and the deodorant is hydroxypropyl beta-cyclodextrin. The bacteriostatic and deodorant cat litter composition can effectively inhibit the breeding of bacteria and molds in the use process of cat litter, is beneficial to keeping the performance of the cat litter in the use process, can adsorb peculiar smell, effectively prevent the peculiar smell from being emitted and reduce the generation of the peculiar smell, also can consider the hardness and water absorption speed of the cat litter, and is easy to agglomerate.

The invention belongs to the field of chemical engineering, and particularly relates to aromatic disinfectant wet wipes and a preparation method thereof. The preparation method comprises the following steps that 2-bromo-2-nitropropane-1,3-propanediol, benzethonium chloride, disodium octaborate tetrahydrate and essence with fixed quantities are produced into disinfectant mixed solution, then the disinfectant mixed solution is dropped onto a piece of carrier towel to wet the carrier towel, the dropping quantity of the disinfectant mixed solution is counted as 1.5ml per gram of the towel, and the aromatic disinfectant wet wipe can be obtained after the towel is wetted. The aromatic disinfectant wet wipes can realize high-efficient and safe sterilization, are toxic-free and harmless to the human body, have a pleasant fragrance, are convenient to carry, can be stored for a long time, are low in price, are suitable for being used in fields such as hotels, restaurants and families and are ideal disinfectant products for outworkers and financial and accountancy personnel to use every day.

The invention discloses an antimicrobial sanitary towel. The antimicrobial sanitary towel comprises a surface layer, wherein an antimicrobial agent containing benzethonium chloride is sprayed onto the surface layer. The antimicrobial sanitary towel can effectively prevent bacteria, the soft surface layer has no irritation to skin, bacteria can be effectively prevented for a long time within the period of use, and accordingly, female health is protected.

The invention relates to a synthetic method of affinity precipitation medium and application thereof to preparation of enoxaparin sodium. The preparation method is as below: salinizing heparin with benzethonium chloride salt in a heparin sodium solution purified by the affinity precipitation medium; esterifying the heparin benzethonium chloride to generate heparin benzyl ester; carrying out depolymerization on heparin benzyl ester in alkaline conditions; the precipitating by ethanol to obtain an enoxaparin sodium crude product; and oxidizing for decolorization by hydrogen peroxide to obtain the enoxaparin sodium fine product. The invention uses crude heparin sodium as a raw material and employs the affinity precipitation medium for purification, so as to effectively remove impurities bonded or non-boned with the heparin, ensure integrity of the natural structure of heparin, increase the activity yield of heparin and provide the basis for the stability and controllability of the subsequent preparation process of the enoxaparin sodium. The invention reduces the production cost, improves production efficiency, and is more suitable for industrial production.

The invention provides an enoxaparin sodium compound and a preparation method thereof. Liquaemin and benzethonium chloride are used as raw materials, sodium chloride is used as a neutral reaction medium and a microwave solid-phase synthesis method is carried out to prepare heparin quaternary ammonium salt.