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Sterilizing preservative composition containing benzethonium chloride and application thereof

A technology of benzethonium chloride and a composition is applied in the field of antiseptic and bactericide compositions, which can solve the problems of lack of broad-spectrum and low activity content, and achieve the effects of improving antibacterial performance, improving antibacterial ability and stable effect.

Active Publication Date: 2011-09-14
BEIJING SUNPU BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the existing patent technology mentioned above, the composition related to benzethonium chloride, because it is directly used for surface disinfection, its active content is low, generally all below 1%, not suitable as an additive in other formulations or used in products; at the same time, benzethonium chloride is a cationic surfactant, if it is directly dissolved in water, it is easy to form a large amount of foam, which will affect the use in many occasions
Compositions containing 3-iodo-2-propynylbutylcarbamate have excellent antifungal properties but lack broad spectrum

Method used

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  • Sterilizing preservative composition containing benzethonium chloride and application thereof
  • Sterilizing preservative composition containing benzethonium chloride and application thereof
  • Sterilizing preservative composition containing benzethonium chloride and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Table 1. Feeding amount of each formula

[0025]

[0026]

[0027] In a three-necked bottle of appropriate size (such as 150ml) with stirring and a thermometer, according to the feeding amount of each formula in Table 1, first add solvent and synergist, heat up to 45°C under stirring, then add benzethonium chloride and antifungal agent, stirred until completely dissolved and then lowered to room temperature, a stable antiseptic and fungicide composition can be obtained. The obtained composition enhances the bactericidal (inhibitory) effect of benzethonium chloride, has a wide bactericidal (inhibitory) spectrum, stable effect, is convenient to use, greatly reduces foam during use, and can be used arbitrarily according to the usage amount.

[0028] IPBC in Table 1 is 3-iodo-2-propynylbutylcarbamate.

Embodiment 2

[0030] Measure the minimum inhibitory concentration (MIC value) of benzethonium chloride aqueous solution (20%) and the part formula composition in embodiment 1 table 1 by plate coating method (to mould, saccharomycete) and dilution culture method (to bacterium) , the results are shown in Table 2.

[0031] Table 2. Minimum inhibitory concentration (MIC value) ppm

[0032]

[0033]

[0034] Note: the value in brackets under each formula is the content of benzethonium chloride.

[0035] As can be seen from Table 2, formula 2 # 、3 # 、5 # ,, 6 # ,8 # Compared with the benzethonium chloride aqueous solution (20%), due to the synergistic effect between the components, under the equivalent benzethonium chloride active substance concentration (all converted into 20%), the composition of the present invention, its actual antibacterial efficiency (no matter to bacterium, fungus) all will be superior to independent benzethonium chloride, the formula containing IPBC (formula 5...

Embodiment 3

[0037] The benzethonium chloride aqueous solution (20%) and part of the formula composition in Example 1 Table 1 are applied to the preparation of sanitary wet wipes and nonionic hand sanitizers as a bactericide, respectively referring to "GB15979-2002 Hygienic Standard for Disposable Sanitary Articles" " and "GB19877.1-2005 Special Hand Sanitizer", conduct a bactericidal rate test on wet wipes and hand sanitizers, and a stability test on the bactericidal effect of sanitary wipes (37°C accelerated test method). The test strains were Escherichia coli (ATCC25922), Staphylococcus aureus (ATCC6538) and Candida albicans (ATCC10231). The results are shown in Table 3, Table 4 and Table 5.

[0038] Table 3. Sterilization rate of sanitary wipes

[0039]

[0040]

[0041] Table 4. Stability test of bactericidal effect of sanitary wipes

[0042]

[0043]

[0044] Note: The addition amount of each formula in wet wipes is 0.1%

[0045] Test conditions: 37 ~ 40 ℃ incubator, rela...

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Abstract

The invention discloses a sterilizing preservative composition containing benzethonium chloride and an application thereof. The sterilizing preservative composition is composed of 1-50wt% of benzethonium chloride, 0.5-10wt% of antifungal agent, 5-30wt% of synergistic agent and 10-80wt% of solvent. The composite has little foams when being prepared and used, has excellent sterilization (bacteriostat) activity, can be widely applied to personal care products, such as cosmetics, wet tissues, nursing lotion, liquid soap and the like and especially can satisfy the requirement of the sanitary wet tissues and antibacterial liquid soap on the sterilizing rate on bacteria and fungus.

Description

technical field [0001] The present invention relates to an antiseptic and bactericide composition and its application, in particular to a broad-spectrum antiseptic and bactericide composition composed of benzethonium chloride, an antifungal agent, a synergist and a solvent and its application. Background technique [0002] With the improvement of people's quality of life, especially the prevalence of various explosive diseases in recent years, people have higher and higher requirements for public places, home environment and their own hygiene. Antibacterial related products are gradually becoming a necessity in people's daily life. These products need to have broad-spectrum, high-efficiency, and stable characteristics, and have a certain killing rate against typical bacteria and fungi. As antiseptic and bactericide products, the content of antibacterial active substances should be as high as possible, so that the ideal antiseptic and bactericidal effect can be achieved at a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/12A01N37/10A01N33/12A01P1/00A01P3/00A61K8/40A61K8/37A61K8/58A61Q1/00A61Q19/10C11D3/48C11D9/50
Inventor 冯士清蔡宏洋高学敏李平刘春霞
Owner BEIJING SUNPU BIOCHEM TECH
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