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36 results about "Absorption drugs" patented technology

Drug absorption is a pharmacokinetic parameter that refers to the way a drug is absorbed from a pharmaceutical formulation into the bloodstream. Several factors can affect the absorption of a drug into the body.

Sublingual buccal effervescent

A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
Owner:CEPHALON INC

Sublingual buccal effervescent

A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
Owner:CIMA LABS

Timolol long-acting transdermal preparation and application thereof in hemangioma treatment

The invention relates to a timolol long-acting transdermal preparation, comprising the following preparation processes: firstly preparing timolol into a timolol nano-drug or timolol micro-powder, and then preparing the timolol nano-drug or timolol micro-powder into a timolol hydrogel transdermal preparation, an ointment transdermal preparation or a micro-needle transdermal preparation. The invention also relates to an application of the drug in hemangioma treatment. When used for treating infantile hemangioma, the medicine disclosed by the invention is capable of improving the medicine absorption efficiency of the pathological cells, and therefore the treatment effect is improved, the dosage is lowered, and no adverse reactions are generated in the treatment process.
Owner:BEIJING MERSON PHARMA CO LTD

Verifiable absorption drug delivery form based on cyclodextrins

Solid dosage forms are produced by absorbing solutions of drug:cyclodextrin inclusion complexes on absorbing matrices and then drying. The matrices may, but need not, disintegrate in water. The resulting forms are suitable for oral or sublingual administration, and also can be used in topical administrations to mucosa covered tissues. They are particularly suitable for sublingual administration because the eluted, nondisintegrated matrix (e.g., absorbing paper) can be recovered and checked for completion of elution. This enables documentation that effective absorption occurred from the mouth cavity.
Owner:PITHA JOSEF

Administration composition and preparation method and using method thereof

The invention provides an administration composition for transferring medicaments and a preparation method and a using method thereof. The administration composition comprises a solid preparation carrying the effective dose of treatment components, a sorbefacient, a pharmaceutic adjuvant and a biologic adhesion layer containing biologic adhesion polymer, and also comprises a selectable anti-permeable or semipermeable coating layer, so that the treatment components and the sorbefacient in the preparation have unidirectional releasing capacity. The administration composition can promote the absorption of medicaments which are difficult to absorb, improves bioavailability, regulate pharmacokinetic characteristics and improve the absorption efficiency of the medicaments, has low cost and is easy to produce relatively.
Owner:SHANGHAI BIOLAXY MEDICAL SCI & TECH

Skin membrane repair drug

The invention provides a skin membrane repair drug. The skin membrane repair drug is characterized by comprising the following bulk drugs in parts by mass: 10-20 parts of rhizoma coptidis, 5-10 parts of dragon's blood, 10-20 parts of pearl powder, 10-20 parts of bletilla striata, 5-10 parts of dahurian angelica, 25-35 parts of lithospermum and 5-15 parts of safflower. The skin membrane repair drug has the beneficial effects that compatibility between the drug and body tissues is improved, the drug can be fully absorbed by skin and the filled drug is turned into one part of the incomplete tissues, and thus efficacies of purging pathogenic fire, clearing away toxic materials, eliminating dampness, promoting blood circulation, cooling blood, stopping bleeding, relieving pain, removing blood stasis, discharging pus, resisting bacteria and diminishing inflammation, promoting tissue regeneration and the like can be fully exerted, wound healing is promoted and skin grafting procedure is omitted and no or less scars are left. The skin membrane repair drug is applicable to skin membrane repair for burn and scald wounds as well as chronic rhinitis, solar dermatitis, cheilosis, infant red buttock and the like; and the skin membrane repair drug can achieve immediate curing effect after use.
Owner:云南云草堂化妆品有限公司

Administration combination and preparation and use methods thereof

The invention provides an administration combination and a preparation method and a use method thereof. The administration combination comprises treatment components carrying effective doses, absorbefacient, medical auxiliary materials, and solid preparation of a bioadhesive layer containing bioadhesive polymer, and further comprises a selectable impervious or semi-permeable coating layer which ensures that the treatment components and the absorbefacient have unidirectional release capability. A unidirectional release channel with unidirectional release capability is formed through manual or laser ablation technology, and the releasing rates of the treatment components and the absorbefacient in the solid preparation are nearly the same. The invention simultaneously provides the preparation and the use methods of the administration combination. Low-dose solid preparation prepared through a non-solvent granulation process can maintain the uniformity and the stability of the treatment components. The administration combination can promote the absorption of drug difficult to be absorbed, improves the bioavailability, adjusts the pharmacodynamic feature and improves the absorption efficiency of drug, has a low price, and is relatively easy to produce.
Owner:SHANGHAI BIOLAXY MEDICAL SCI & TECH

Bioresorbable drug eluting intravitreal implant system and method

A bioresorbable drug eluting intravitreal implant system includes a syringe with a chamber containing a medicinal drug. A balloon is releasably secured to a needle where the needle has a central section chamber in fluid communication with a chamber in the syringe. The needle central section has an opening formed through a wall for transporting the medicinal drug to the interior of the balloon subsequent to insertion of the needle through the sclera of a patient's eye.
Owner:DRUG DELIVERY CO LLC

Sublingual administration preparation containing total alkaloids in lotus leaf or lotus plumule, and use thereof

The invention belongs to the technical field of traditional Chinese pharmacology, and discloses a preparation method and a use of a sublingual administration preparation containing alkaloids extracted from lotus leaf or lotus plumule. The sublingual administration preparation can be rapidly absorbed by sublingual mucous membrane, directly enters blood, avoids first pass effect of livers, is convenient to take, and has reduced untoward effects and improved the curative effect.
Owner:宋金春 +2

Oral disintegrated difenidol hydrochloride tablet and its prepn process

The present invention discloses oral disintegrated difenidol hydrochloride tablet prepared through freeze- drying process and its preparation process. The oral disintegrated difenidol hydrochloride tablet has difenidol hydrochloride as main medicine component, solid dispersing carrier, disintegrant, effervescent agent, taste masking agent, excipient, etc. and features the freeze- drying preparing process. It may be disintegrated in oral cavity into particles smaller than 250 microns within 30 sec without need of water, and is especially suitable for patient with dysphagia. It has fast leaching out and absorption, fast acting and high bioavailability.
Owner:北京正光恒业控释制剂研究中心 +1

Radiopaque polyvinyl alcohol microsphere

The invention relates to a radiopaque polyvinyl alcohol microsphere and a preparation method thereof, wherein the radiopaque polyvinyl alcohol microsphere comprises a polyvinyl alcohol hydrogel bead,2, 3, 5-triiodobenzaldehyde and organic acids. The radiopaque polyvinyl alcohol microspheres prepared by the invention have the advantages of short synthesis time, fast absorption rate of drugs and the like.
Owner:赵修文

A kind of fixed dressing for oncology picc-associated dermatitis

The invention discloses a fixed dressing for PICC-associated dermatitis in oncology department, relates to the technical field of auxiliary treatment equipment for postoperative wounds, and aims at the existing dressings which are easy to be misplaced in use position, inconvenient to replace the dressing, and the use rate of static dressing is low, and the wound In view of problems such as slow surface recovery, the following scheme is now proposed, including a storage box, the two sides of the storage box are fixedly connected with a connecting mechanism, and the connecting mechanism includes a cover plate, and a mounting plate is welded on the bottom of the cover plate. The outer ring of the mounting plate is provided with a connecting plate, which is welded with the outer wall of the storage box, and a cavity is opened in the connecting plate. The invention has a novel design structure, the position of the dressing is fixed simply and quickly, reducing the workload of medical staff, the bandage is elastic and the patient’s movement will not affect the degree of tightness, and the dressing is used for temperature control and heating to improve the recovery effect of the drug, which is beneficial to the absorption of the drug by the affected part, and assists in healing Speed, reduce patient discomfort, suitable for popularization.
Owner:GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY

Ticagrelor pharmaceutical composition as well as preparation method and application thereof

The invention provides a ticagrelor pharmaceutical composition. The composition comprises ticagrelor and a pharmaceutically acceptable carrier, wherein the weight percentage of the ticagrelor is 10%-20%, the pharmaceutically acceptable carrier is selected from any one or a combination of an adhesive, a disintegrating agent, a diluent, a lubricant and a glidant, and the weight percentage of the disintegrating agent is 10%-30%. By scientifically screening and optimizing the formula of a solid pharmaceutical composition, the dynamic disintegration time and the static disintegration time of tablets are remarkably shortened, a patient can quickly absorb a medicine conveniently, intubation is avoided, a clinical medication scheme is simplified, in addition, medication of a patient with dysphagia is facilitated, the medication compliance of the patient is remarkably improved, the particle size and the particle powder property of the ticagrelor are optimized, the problems of large tablet weight difference and poor content uniformity after tabletting caused by poor flowability of the ticagrelor are solved, the uniformity, effectiveness and safety of the medicine are improved, and the quality of the medicine is controllable.
Owner:弘和制药有限公司 +1

Externally-used traditional Chinese medicine composition for treating migraine

The invention provides an externally-used traditional Chinese medicine composition for treating migraine. According to the composition, ligusticum wallichii is taken as a monarch drug in a prescription; fructus viticis, radix angelicae and notopterygium root for dispelling wind and relieving pain are taken as ministerial drugs; rhizoma corydalis is used for assisting in the monarch drug, the ministerial drugs are used for relieving pain, radix achyranthis bidentatae is used for ensuring proper downward flow of blood, and all the drugs are taken adjuvant drugs; and platycodon grandiflorum is taken a conductant drug. The drugs are combined for clearing upward flow and reducing downward flow, clearing heat in head, bringing illness out and rising qi while reducing heat so as to achieve the effects of dispersing blood stasis, dispelling wind and relieving pain. The drugs can be coordinated by honey. The traditional Chinese medicine composition is applied to acupoints of Yifeng, Geshu, Fengshi, Yongquan and Taichong on the two sides of a human body. The traditional Chinese medicine composition is reasonable in combination, and can be used for fulfilling the effects of dispersing blood stasis, relaxing bowels, dispelling wind and relieving pain in a comprehensive manner. Modern researches show that when the traditional Chinese medicine composition is applied to the corresponding acupoints, the traditional Chinese medicine composition can be better absorbed through the specific parts, the acupoints can be stimulated, meridian qi of main and collateral channels can be excited, the dual functions of the composition and the main and collateral channels can be brought into play, and thus the aim of preventing and treating diseases can be achieved. The total effective rate of the externally-used traditional Chinese medicine composition is up to 89.8%.
Owner:杜言辉

Method for separating and preparing pyrrole butyric acid self-emulsion from radix ranunculi ternati and application of pyrrole butyric acid self-emulsion

The invention discloses a method for separating and preparing pyrrole butyric acid self-emulsion from radix ranunculi ternati and the application of the pyrrole butyric acid self-emulsion. In the method, smashed particles of the radix ranunculi ternati herb or radix ranunculi ternati decoction pieces serve as raw material and are concentrated, extracted and washed to obtain the effective constituent pyrrole butyric acid, and then the pyrrole butyric acid self-emulsion is prepared. According to the method, the effective constituent pyrrole butyric acid can be efficiently extracted, and the radix ranunculi ternati serving as the natural raw material has the advantages of being easy to obtain and low in cost. Serving as a good carrier for drugs which are hard to dissolve and absorb, the pyrrole butyric acid self-emulsion prepared through the method can greatly increase the oral bioavailability of the drugs; a drug delivery system of the pyrrole butyric acid self-emulsion is easy to prepare and stable in nature and is a good carrier for improving the absorbability of the drugs which are hard to dissolve; as is proven in experimental verification, the pyrrole butyric acid self-emulsion prepared through the method has an excellent tubercle bacillus inhibiting effect.
Owner:JIANGSU YONGZHANG WEIYE HEALTH TECH

Submucosal bioabsorbable drug elution platform

Described herein are systems and methods for delivering an active agent to a target tissue of the ear, nose, or throat using a drug delivery platform having a therapeutic drug embedded as part of the drug delivery platform. The drug delivery platform is implanted in a target tissue, and the active agent is eluted from the body of the drug delivery platform for a target period of time, thereby delivering a therapeutic dose of the drug for the period of time. The duration of therapy of the implant into sinus tissue may be 3 to 12 months or longer, thereby providing an entire duration of alleviation for the duration of the allergy season. Furthermore, the duration of the therapy provides remission to an individual suffering from a symptom of a chronic paranasal sinus condition for a longer period of time than currently available therapies, thus allowing the therapy to be administered only every half a year or year.
Owner:INTERSECT ENT INC

Administration method for transferring zinc oxide nano-particles into brain through gustatory nerves

The invention discloses an administration method for transferring zinc oxide nano-particles into brain through gustatory nerves, the administration method comprises the following steps: preparing a zinc oxide nano-particle suspension, dropwise adding the zinc oxide nano-particle suspension on the tongue according to the body weight so that the zinc oxide nano-particle suspension is uniformly distributed on the whole tongue tissue, and after the administration is finished, repeatedly flushing the tongue with sterile water, and wiping with a sterile cotton swab until the residual zinc oxide nanoparticle suspension on the tongue is thoroughly removed. The zinc oxide nano-particles have excellent rational properties such as small particle size, large specific surface area, high biological activity and the like, and medicines can be transferred into the brain by utilizing gustatory nerves in a tongue body administration mode. The tongue tissue has the advantages of large surface area, high absorption speed and the like, and can quickly absorb the medicine; meanwhile, external interference can be effectively removed through tongue body instillation, and the situation that medicine is transferred to the whole body along with blood is reduced. The whole body action of the medicine can be avoided, the dosage of the medicine can be reduced and the action efficiency of the medicine can be improved.
Owner:南方医科大学口腔医院

Enzalutamide soft capsule quick-release preparation and preparation method thereof

The invention relates to the technical field of medicines, in particular to an enzalutamide soft capsule quick-release preparation and a preparation method thereof. The enzalutamide soft capsule quick-release preparation is composed of a capsule shell and a content, wherein the content is a suspension containing enzalutamide. The enzalutamide soft capsule quick-release preparation is composed of the following raw materials in parts by weight of 40 parts of enzalutamide, 40-60 parts of medium chain triglyceride, 50-100 parts of a thickening agent, and 0.3-5 parts of a flow aid. According to theenzalutamide soft capsule quick-release preparation disclosed by the invention, aiming at the property characteristics of enzalutamide medicines, a soft capsule is prepared by adopting a suspension system, so that the dispersion and absorption of the enzalutamide are promoted, the chemical and physical stability of the medicines is good, the dissolution of effective components is quick, and the bioavailability is high. The invention also provides the preparation method of the enzalutamide soft capsule quick-release preparation.
Owner:REYOUNG PHARMA

Externally-used traditional Chinese medicine composition for treating migraine

The invention provides an externally-used traditional Chinese medicine composition for treating migraine. According to the composition, ligusticum wallichii is taken as a monarch drug in a prescription; fructus viticis, radix angelicae and notopterygium root for dispelling wind and relieving pain are taken as ministerial drugs; rhizoma corydalis is used for assisting in the monarch drug, the ministerial drugs are used for relieving pain, radix achyranthis bidentatae is used for ensuring proper downward flow of blood, and all the drugs are taken adjuvant drugs; and platycodon grandiflorum is taken a conductant drug. The drugs are combined for clearing upward flow and reducing downward flow, clearing heat in head, bringing illness out and rising qi while reducing heat so as to achieve the effects of dispersing blood stasis, dispelling wind and relieving pain. The drugs can be coordinated by honey. The traditional Chinese medicine composition is applied to acupoints of Yifeng, Geshu, Fengshi, Yongquan and Taichong on the two sides of a human body. The traditional Chinese medicine composition is reasonable in combination, and can be used for fulfilling the effects of dispersing blood stasis, relaxing bowels, dispelling wind and relieving pain in a comprehensive manner. Modern researches show that when the traditional Chinese medicine composition is applied to the corresponding acupoints, the traditional Chinese medicine composition can be better absorbed through the specific parts, the acupoints can be stimulated, meridian qi of main and collateral channels can be excited, the dual functions of the composition and the main and collateral channels can be brought into play, and thus the aim of preventing and treating diseases can be achieved. The total effective rate of the externally-used traditional Chinese medicine composition is up to 89.8%.
Owner:杜言辉

Online judgment method for absorption end point of typical modified double-base propellant absorption drug

The invention discloses an online judgment method for an absorption end point of a typical modified double-base propellant absorption drug. The method comprises the following steps of firstly, respectively collecting NC with different concentrations and near infrared spectrums of high-energy explosives, determining typical characteristic peaks, and selecting a characteristic wave band as a basis for calculating the standard deviation of a moving window; then setting a workflow of repeated sampling in the absorption process; then simulating an absorption process, and carrying out real-time and online acquisition on the mixing condition of the absorption process; and finally, at different mixing time points, selecting n continuous spectrums each time for calculation, calculating real-time difference and standard deviation between the whole process and near infrared spectrums of characteristic peaks of main components through an MBSD algorithm, and judging an absorption end point. The method is advantaged in that by selecting the near infrared spectrum characteristic peaks of the components of the absorption medicine and prolonging the duration time of the mixing process, the mixing uniformity change condition of the absorption process is comprehensively reflected, an absorption end point is accurately judged, and a comprehensive and reasonable basis is provided for actual production of the absorption medicine.
Owner:NANJING UNIV OF SCI & TECH

New material and preparation method of coronary artery stent

The invention discloses a new material and preparation method of a coronary stent. The main material of the stent is synthesized from titanium, cobalt, magnesium, nickel and iron, and the adsorption material is composed of sterile cotton and the polyhydroxyalkanoate. Asparagus leaves, Rhododendron azalea, staghorn glue, forsythia, Prunella vulgaris, Corydalis, cicada slough, Lismodium, cat's claw, geranium, pinellia, honeysuckle, Angelica dahurica, gardenia, scutellaria baicalensis, and red peony make up the adsorption drug material , compared with the prior art, the present invention adopts various alloys, which can improve the setting ability of the coronary stent and keep it without deformation. The effect has the value of popularization and application.
Owner:JILIN UNIV
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