Administration combination and preparation and use methods thereof

Abstract

The invention provides an administration combination and a preparation method and a use method thereof. The administration combination comprises treatment components carrying effective doses, absorbefacient, medical auxiliary materials, and solid preparation of a bioadhesive layer containing bioadhesive polymer, and further comprises a selectable impervious or semi-permeable coating layer which ensures that the treatment components and the absorbefacient have unidirectional release capability. A unidirectional release channel with unidirectional release capability is formed through manual or laser ablation technology, and the releasing rates of the treatment components and the absorbefacient in the solid preparation are nearly the same. The invention simultaneously provides the preparation and the use methods of the administration combination. Low-dose solid preparation prepared through a non-solvent granulation process can maintain the uniformity and the stability of the treatment components. The administration combination can promote the absorption of drug difficult to be absorbed, improves the bioavailability, adjusts the pharmacodynamic feature and improves the absorption efficiency of drug, has a low price, and is relatively easy to produce.

Description

technical field [0001] The invention mainly relates to the field of drug delivery, and is especially suitable for pharmaceutical components with poor absorption and low bioavailability in traditional administration, so as to improve the absorption and bioavailability of therapeutic drugs. In particular, the invention relates to drug delivery compositions and methods for their preparation and use. Background technique [0002] Oral administration is the most common and most acceptable way of administration. But for many drugs, the absorption efficiency of oral administration is not good. For example, biologically active macromolecules such as proteins, polypeptides, polysaccharides, and nucleic acids cannot usually be administered orally due to factors such as enzymatic degradation, poor absorption, or instability. Similarly, many small molecule drugs, such as cyclosporine A, fenofibrate, statin lipid-lowering drugs, sartan antihypertensive drugs, antibiotics such as ceftri...

AI Technical Summary

Problems solved by technology

However, the addition of such high doses of absorption enhancers in oral formulations often leads to toxic reactions and safety concerns

[0007] So far, there is no safe and effective solution for those oral drugs that are difficult to absorb and have low bioavailability, especially macromolecular drugs

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