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Oral disintegrated difenidol hydrochloride tablet and its prepn process

A technology of diphenidol hydrochloride and orally disintegrating tablets, which is applied in the field of medicine, can solve the problems of inconvenient use, lack of use, and poor compliance of patients, and achieve the effects of fast onset, high bioavailability, and fast disintegration

Inactive Publication Date: 2007-03-21
北京正光恒业控释制剂研究中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ordinary tablets need to drink water and complete the medication process by swallowing. For children, the elderly and patients with difficulty in swallowing, the compliance is poor, and the use in some special conditions is restricted such as lack of drinking water
Although injections take effect quickly, they must be assisted by medical staff, which is inconvenient for patients to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Weigh 4.0 g of mannitol, add it to 20 ml of water, stir to dissolve, add 1.0 g of gelatin, 1.0 g of difenidol hydrochloride to dissolve, then add 1.0 g of aspartame, stir or sonicate or grind to dissolve , add water to 40ml, mix well, filter through a G3 filter, fill, freeze-dry, aluminum-plastic, pack, and get ready.

Embodiment 2

[0016] Example 2: Weigh 20g of hydroxypropyl-β-cyclodextrin, add 40ml of water and stir to dissolve, add 1.0g of difenidol hydrochloride, stir or ultrasonically or grind to dissolve, add water to 80ml, mix well, pass through G3 After being filtered by a filter, filling, freeze-drying, aluminum-plasticizing, packaging, and the product is obtained.

Embodiment 3

[0017] Example 3: Weigh 2.0 g of hydroxypropyl-β-cyclodextrin, add 10 ml of water and stir to dissolve, add 1.0 g of difenidol hydrochloride, stir or ultrasonically or grind to dissolve, add 1.0 g of aspartame to dissolve , add water to 20ml, mix well, filter through a G3 filter, fill, freeze-dry, aluminum-plastic, pack, and get ready.

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PUM

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Abstract

The present invention discloses oral disintegrated difenidol hydrochloride tablet prepared through freeze- drying process and its preparation process. The oral disintegrated difenidol hydrochloride tablet has difenidol hydrochloride as main medicine component, solid dispersing carrier, disintegrant, effervescent agent, taste masking agent, excipient, etc. and features the freeze- drying preparing process. It may be disintegrated in oral cavity into particles smaller than 250 microns within 30 sec without need of water, and is especially suitable for patient with dysphagia. It has fast leaching out and absorption, fast acting and high bioavailability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an orally disintegrating tablet form, in particular to a difenidol hydrochloride orally disintegrating tablet with quick-release effect prepared by a freeze-drying method and a preparation method thereof. Background technique [0002] Difenidol hydrochloride (difcnidol hydrochloride) chemical name is α, α-diphenyl-1-piperidine butanol hydrochloride, also known as Vertigo, Diphenperidine, Difenydol, etc. Azines. This product has a strong antiemetic effect and is used for dizziness and vomiting caused by various diseases. This product has definite curative effect and few side effects. Currently, there are only ordinary tablets and injections of this drug on the pharmaceutical market. [0003] Ordinary tablets need to drink water and complete the medication process by swallowing actions. Children, the elderly and patients with difficulty in swallowing have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61K9/20A61P1/08
Inventor 王登之李勇枝陈善广侯鹏高建义宁宗超李媛白水昭
Owner 北京正光恒业控释制剂研究中心
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